Vitamin D and hypertension
Description
Pawlicka Marta, Fałkowska Urszula, Bałabuszek Kamil, Radzka Agnieszka, Mroczek Anna, Bednarski Jerzy. Vitamin D and hypertension. Journal of Education, Health and Sport. 2018;8(9):219-228. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1346149
http://ojs.ukw.edu.pl/index.php/johs/article/view/5823
https://pbn.nauka.gov.pl/sedno-webapp/works/873793
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1223 Journal of Education, Health and Sport eissn 2391-8306 7
© The Authors 2018;
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Received: 02.06.2018. Revised: 18.06.2018. Accepted: 16.08.2018.
Vitamin D and hypertension
Marta Pawlicka1, Urszula Fałkowska1, Kamil Bałabuszek1, Agnieszka Radzka1, Anna Mroczek1, Jerzy Bednarski2
1 Student Research Circle at the Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, Poland
2 Department of Human Anatomy, Chair of Human Anatomy, Medical University of Lublin, Poland
ORCID ID
Marta Pawlicka https://orcid.org/0000-0002-6631-979X
Urszula Fałkowska https://orcid.org/0000-0002-8561-8904
Kamil Bałabuszek https://orcid.org/0000-0002-1352-153X
Agnieszka Radzka https://orcid.org/0000-0002-3484-4602
Anna Mroczek https://orcid.org/0000-0003-0077-5343
Jerzy Bednarski https://orcid.org/0000-0002-0186-3268
Abstract
Introduction: Current epidemiological studies indicate, that insufficiency of vitamin D affects 50% of the population worldwide. 1α,25(OH)2D – active form of vitamin D affects tissues and organs through vitamin D receptor (VDR). Attention to the role of vitamin D deficiency in hypertension development has been continuously increased during recent decades.
The aim of the study: The purpose of this narrative systemic review was to analyse and summarize available data on role of vitamin D deficiency in hypertension development.
Material and method: Standard criteria were used to review the literature data. The search of articles in the PubMed and Google Scholar database was carried out using the following keywords: hypertension, calcitriol, vitamin D, 25-hydroxyvitamin D.
Description of the state of knowledge: Vitamin D influence blood pressure level through renin-angiotensin-aldosterone system (RAAS) and parathormone regulation. Studies conducted on animal model could explain possible mechanism of vitamin D influence on blood pressure control. However, clinical trial results are equivocal due to differences in sample size, heterogeneity of patient baseline characteristics, different vitamin D doses and study duration.
Summary: Further research is needed to confirm the role of vitamin D in hypertension development.
Key words: vitamin D, hypertension, blood pressure, cholecalciferol
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