Study of Nerve Conduction in Non-Diabetic Offspring of Type 2 Diabetic Parents of Students in NMCH, Patna
Authors/Creators
- 1. Tutor, Department of Physiology, Nalanda Medical College & Hospital, Patna, Bihar, India
- 2. Associate Professor & HOD, Department Of Physiology, Nalanda Medical College & Hospital, Patna, Bihar, India
Description
Introduction: Diabetes is a major contributor to global morbidity and mortality. Genetic factors play a significant role in the development of the disease, and various gene polymorphisms and mutations may influence its clinical presentation. Recent studies on the genetic components of type 2 diabetes mellitus (T2DM) have demonstrated that early indications of altered brain and autonomic systems are present in even non-diabetic children of diabetic parents. Objectives: The objective is to examine the median motor nerve conduction parameters in non-diabetic offspring of parents with T2DM compared to those with non-diabetic parents, and to analyze any differences between these groups. Methods: On the hands of sixty healthy individuals between the ages of eighteen and twenty-five, a nerve conduction investigation of the motor component of the median nerve was carried out. All of the study’s participants had normal BMIs and were divided equally into two groups: 30 children of parents with T2DM and 30 children of parents without the disease. Results: The motor component of the median nerve’s latency, amplitude, and conduction velocity did not significantly change between the two groups. Conclusion: There were no discernible variations in motor nerve latencies between the groups according to the study. This is in contrast to results from earlier research in comparable populations that showed altered visually evoked potentials and autonomic dysfunction. The lack of engagement of the somatic nerve may be explained by the glycation of neural structures, which may have an impact on neuronal activity.
Abstract (English)
Introduction: Diabetes is a major contributor to global morbidity and mortality. Genetic factors play a significant role in the development of the disease, and various gene polymorphisms and mutations may influence its clinical presentation. Recent studies on the genetic components of type 2 diabetes mellitus (T2DM) have demonstrated that early indications of altered brain and autonomic systems are present in even non-diabetic children of diabetic parents. Objectives: The objective is to examine the median motor nerve conduction parameters in non-diabetic offspring of parents with T2DM compared to those with non-diabetic parents, and to analyze any differences between these groups. Methods: On the hands of sixty healthy individuals between the ages of eighteen and twenty-five, a nerve conduction investigation of the motor component of the median nerve was carried out. All of the study’s participants had normal BMIs and were divided equally into two groups: 30 children of parents with T2DM and 30 children of parents without the disease. Results: The motor component of the median nerve’s latency, amplitude, and conduction velocity did not significantly change between the two groups. Conclusion: There were no discernible variations in motor nerve latencies between the groups according to the study. This is in contrast to results from earlier research in comparable populations that showed altered visually evoked potentials and autonomic dysfunction. The lack of engagement of the somatic nerve may be explained by the glycation of neural structures, which may have an impact on neuronal activity.
Files
IJPCR,Vol16,Issue5,Article473.pdf
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Additional details
Dates
- Accepted
-
2024-05-10
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue5,Article473.pdf
- Development Status
- Active
References
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