Published August 31, 2022 | Version https://impactfactor.org/PDF/IJPCR/14/IJPCR,Vol14,Issue8,Article126.pdf
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A Prospective Study to Assess the Correlation between EVLWI and PVPI with the Severity of Lung Injury in Patients Admitted with Septic Shock in Intensive Care Unit

  • 1. PDCC, Senior Resident, Department of Critical Care Medicine (Anesthesiology), IGIMS, Patna, Bihar, India
  • 2. Fellow, Senior Resident, Department of Emergency and Critical Care (Trauma and Emergency) IGIMS, Patna, Bihar, India
  • 3. Assistant Professor, Department of Trauma and Emergency, IGIMS, Patna, Bihar, India

Description

Aim: The aim of the present study was conducted in the Intensive Care Unit (ICU) of our institute, with an aim to assess the correlation between EVLWI and PVPI with the severity of lung injury in patients with septic shock. Methods: The present study was conducted in the Department of  Critical Care medicine (Anesthesiology), IGIMS, Patna, Bihar, India for 1 year. Results: The chest radiograph scores from both radiologists strongly correlated with EVLWI (r = 0.75 and 0.70 for observers 1 and 2, respectively, P < 0.0001 for both observers). A moderate correlation between chest radiograph scores and PVPI was obtained (r = 0.64 and 0.60 for observers 1 and 2, respectively, P < 0.0001 for both observers). The chest radiograph scores from the two independent observers correlated strongly with each other (r = 0.78, P < 0.0001). Conclusion: EVLWI and PVPI may have a prognostic significance in the assessment of lung injury in septic shock patients with ARDS. Further research is required to reveal the usefulness of EVLWI as an end point of fluid resuscitation in the management of septic shock with ARDS.

 

 

 

Abstract (English)

Aim: The aim of the present study was conducted in the Intensive Care Unit (ICU) of our institute, with an aim to assess the correlation between EVLWI and PVPI with the severity of lung injury in patients with septic shock. Methods: The present study was conducted in the Department of  Critical Care medicine (Anesthesiology), IGIMS, Patna, Bihar, India for 1 year. Results: The chest radiograph scores from both radiologists strongly correlated with EVLWI (r = 0.75 and 0.70 for observers 1 and 2, respectively, P < 0.0001 for both observers). A moderate correlation between chest radiograph scores and PVPI was obtained (r = 0.64 and 0.60 for observers 1 and 2, respectively, P < 0.0001 for both observers). The chest radiograph scores from the two independent observers correlated strongly with each other (r = 0.78, P < 0.0001). Conclusion: EVLWI and PVPI may have a prognostic significance in the assessment of lung injury in septic shock patients with ARDS. Further research is required to reveal the usefulness of EVLWI as an end point of fluid resuscitation in the management of septic shock with ARDS.

 

 

 

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Dates

Accepted
2022-08-18

References

  • 1. Perel A, Monnet X. Extravascular lung water. In: Vincent J, Hall J (eds) Encyclopedia of intensive care medicine. Springer-Verlag, Berlin Heidelberg; 2011. 2. Kushimoto S., Taira Y., Kitazawa Y., Okuchi K., Sakamoto T., Ishikura H., Endo T., Yamanouchi S., Tagami T., Yamaguchi J. and Yoshikawa K. The clinical usefulness of extravascular lung water and pulmonary vascular permeability index to diagnose and characterize pulmonary edema: a prospective multicenter study on the quantitative differential diagnostic definition for acute lung injury/acute respiratory distress syndrome. Critical Care, 2012;16(6):1-15. 3. Martin GS, Eaton S, Mealer M, Moss M. Extravascular lung water in patients with severe sepsis: a prospective cohort study. Critical care. 2005 Apr; 9(2):1-9. 4. Sakka SG, Klein M, Reinhart K, Meier-Hellmann A. Prognostic value of extravascular lung water in criticallyill patients. Chest. 2002 Dec 1;122 (6): 2080-6. 5. Monnet X, Anguel N, Osman D, Hamzaoui O, Richard C, Teboul JL. Assessing pulmonary permeability by transpulmonary thermodilution allows differentiation of hydrostatic pulmonary edema from ALI/ARDS. Intensive care medicine. 2007 Mar; 33 (3):448-53. 6. Katzenelson R, Perel A, Berkenstadt H, Preisman S, Kogan S, Sternik L, Segal E. Accuracy of transpulmonary thermodilution versus gravimetric measurement of extravascular lung water. Critical care medicine. 2004 Jul 1;32(7):1550-4. 7. Brown LM, Liu KD, Matthay MA. Measurement of extravascular lung water using the single indicator method in patients: research and potential clinical value. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2009 Oct;297 (4): L547-58. 8. Velayati AA, Farnia P, Masjedi MR. Totally drug-resistant tuberculosis (TDR-TB): A debate on global health communities. International journal of mycobacteriology. 2013 Jun; 2(2):71- 2. 9. Velayati AA, Abeel T, Shea T, Zhavnerko GK, Birren B, Cassell GH, Earl AM, Hoffner S, Farnia P. Populations of latent Mycobacterium tuberculosis lack a cell wall: Isolation, visualization, and whole-genome characterization. International Journal of Mycobacteriology. 2016 Mar 1; 5(1): 66-73. 10. Hashemian SM, Farhadi T, Ganjparvar M. Linezolid: a review of its properties, function, and use in critical care. Drug design, development and therapy. 2018; 12:1759. 11. Miserocchi G. Mechanisms controlling the volume of pleural fluid and extravascular lung water. European Respiratory Review. 2009 Dec 1;18 (114):244-52. 12. Ware LB, Matthay MA. Acute pulmonary edema. New England Journal of Medicine. 2005 Dec 29;35 3(26):2788-96. 13. Practice parameters for hemodynamic support of sepsis in adult patients in sepsis. Task Force of the American College of Critical Care Medicine, Society of Critical Care Medicine. Crit Care Med 1999; 27:639-60. 14. Halperin BD, Feeley TW, Mihm FG, Chiles C, Guthaner DF, Blank NE. Evaluation of the portable chest roentgenogram for quantitating extravascular lung water in critically ill adults. Chest. 1985 Nov 1;88(5):649-5 2. 15. Force AD, Ranieri VM, Rubenfeld GD, Thompson B, Ferguson N, Caldwell E, Fan E, Camporota L, Slutsky AS. Acute respiratory distress syndrome. Jama. 2012 Jun 20; 307(23): 2526-33. 16. Brown LM, Calfee CS, Howard JP, Craig TR, Matthay MA, McAuley DF. Comparison of thermodilution measured extravascular lung water with chest radiographic assessment of pulmonary oedema in patients with acute lung injury. Annals of intensive care. 2013 Dec; 3(1):1-8. 17. Szakmany T, Heigl P, Molnar Z. Correlation between extravascular lung water and oxygenation in ALI/ARDS patients in septic shock: possible role in the development of atelectasis? Anaesthesia and intensive care. 2004 Apr; 32(2):196-201. 18. Laggner A, Kleinberger G, Sommer G, Haller J, Lenz K, Base W, Druml W. Determination of extravascular lung water in critical patients: Comparison with radiological, hemodynamic and functional lung findings. Schweizerische Medizinische Wochenschrift. 1985 Feb 1;115(6):210-3. 19. Touho H, Karasawa J, Shishido H, Yamada K, Yamazaki Y. Hypoxemia in the acute stage of hypertensive intracerebral hemorrhage, with specialreference to increased extravascular lung water. Neurologia medicochirurgica. 1989;29(8):724-7. 20. Knoch M, Vogell H, Höltermann W, Müller E, Lennartz H. The measurement of extravascular lung water-significant in the follow-up of ARDS? Anasthesie, Intensivtherapie, Notfallmedizin. 1990 Dec 1;25(6):411- 5. 21. Tyagi A, Sethi AK, Girotra G, Mohta M. The microcirculation in sepsis. Indian J Anaesth 2009; 53:281-93. 22. Jozwiak M, Silva S, Persichini R, Anguel N, Osman D, Richard C, Teboul JL, Monnet X. Extravascular lung water is an independent prognostic factor in patients with acute respiratory distress syndrome. Critical care medicine. 2013 Feb 1;41(2):472- 80. 23. Chung FT, Lin HC, Kuo CH, Yu CT, Chou CL, Lee KY, Kuo HP, Lin SM. Extravascular lung water correlates multiorgan dysfunction syndrome and mortality in sepsis. PLoS One. 2010 Dec 16;5(12): e15265. 24. Alhindi A., Al-karirri M., Kanoa, B., Abu Ouda S. S., Erqyq Y. M., Radwan,A. I., & Jalambo M. O. Hand washing as an effective technique for intestinal parasites control among school children in Gaza city: Hand washing as an effective technique for intestinal parasites control. Journal of Medical Research and Health Sciences, 2021;4(11): 1557–1564.