Evaluation of Anti-Inflammatory Activity of Parthenium Hysterophorus [Congress Grass]: An Experimental Study in Rat Models. (Carrageenan-Induced Paw Oedema Model)
Creators
- 1. Assistant Professor, Department of Pharmacology, Chhindawara Institute of Medical Sciences, Chhindwara (Madhya Pradesh)
- 2. Professor, Department of Community Medicine, Government Medical College Bharatpur (Rajasthan)
- 3. Professor, Department of Pharmacology, Mahatma Gandhi Institute of Medical Sciences, Sevagram (Maharashtra)
- 4. Assistant Professor, Department of Dentistry, Chhindawara Institute of Medical Sciences, Chhindwara (Madhya Pradesh)
- 5. Demonstrator, Department of Pharmacology, Chhindawara Institute of Medical Sciences, Chhindwara( Madhya Pradesh )
- 6. Associate Professor, Department of Pharmacology, Shri Ram Murthi Smarak Institute of Medical Sciences, Bareilly (Uttar Pradesh)
Description
Background: Parthenium hysterophorus is an aggressive ubiquitous annual herbaceous weed with medicinal properties used by some tribes as a remedy for inflammation, eczema, skin rashes, rheumatic pain, and gynaecological ailments and found to be pharmacologically active as an analgesic in muscular rheumatism, therapeutic for neuralgia and as a vermifuge. The decoction of P. Hysterophorus has been used in traditional medicine to treat fever, diarrhea, neurologic disorders, urinary tract infections, dysentery, malaria and as an emmenagogue. Methods: The powdered aerial part of the plant was macerated with 70% v/v ethanol and hydroalcoholic extracts were obtained by percolation. A fresh solution was prepared by dissolving the extract in distilled water before the experiment. Carrageenan-Induced Paw Oedema Model used for evaluating anti-inflammatory activity. The albino Wistar rats of either sex were divided into 5 groups with six animals in each group and received either PH extract p.o. (200, 400,800 mg/kg), Aspirin (630 mg/kg) or control (1ml distilled water p.o.). 1% carrageenan solution was prepared and injected in the left hind paw (planter aspect) after 60 minutes of oral administration of standard and test drugs. Right hind paw kept as control. Results: Parthenium Hysterophorus extract showed significant inhibition of oedema at the dose of 400, 800 mg/kg at the end of 4 and 24 hours. Conclusion: Parthenium Hysterophorus extract exhibited significant anti-inflammatory activity in experimental analysis in Rats.
Abstract (English)
Background: Parthenium hysterophorus is an aggressive ubiquitous annual herbaceous weed with medicinal properties used by some tribes as a remedy for inflammation, eczema, skin rashes, rheumatic pain, and gynaecological ailments and found to be pharmacologically active as an analgesic in muscular rheumatism, therapeutic for neuralgia and as a vermifuge. The decoction of P. Hysterophorus has been used in traditional medicine to treat fever, diarrhea, neurologic disorders, urinary tract infections, dysentery, malaria and as an emmenagogue. Methods: The powdered aerial part of the plant was macerated with 70% v/v ethanol and hydroalcoholic extracts were obtained by percolation. A fresh solution was prepared by dissolving the extract in distilled water before the experiment. Carrageenan-Induced Paw Oedema Model used for evaluating anti-inflammatory activity. The albino Wistar rats of either sex were divided into 5 groups with six animals in each group and received either PH extract p.o. (200, 400,800 mg/kg), Aspirin (630 mg/kg) or control (1ml distilled water p.o.). 1% carrageenan solution was prepared and injected in the left hind paw (planter aspect) after 60 minutes of oral administration of standard and test drugs. Right hind paw kept as control. Results: Parthenium Hysterophorus extract showed significant inhibition of oedema at the dose of 400, 800 mg/kg at the end of 4 and 24 hours. Conclusion: Parthenium Hysterophorus extract exhibited significant anti-inflammatory activity in experimental analysis in Rats.
Files
IJPCR,Vol14,Issue8,Article86.pdf
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Additional details
Dates
- Accepted
-
2022-08-15
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/14/IJPCR,Vol14,Issue8,Article86.pdf
- Development Status
- Active
References
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