Effect of Prophylactic Ondansetrone on Prevention of Spinal Induced Hypotension among Women underwent Elective Cesarean Section
Creators
- 1. Assistant Professor, Department of Anaethesiology, K. M. Medical College, Mathura, U.P.
- 2. HOD & Senior Consultant, Department of Anaethesiology, Yetharth Super Specialty Hospital, Noida, U.P.
- 3. Associate Professor, Department of Anaethesiology, Santosh Medical College & Hospital, Ghaziabad, U.P.
- 4. Assistant Professor, Department of Anaethesiology & Critical Care, Nalanda Medical College and Hospital, Patna, Bihar
Description
Background: Hypotension is a common side effect after spinal anesthesia which associates with both maternal and fetal morbidity. Many interventions have been suggested to prevent this clinical problem. A commonly used antiemetic, ondansetron, can be used as an alternative to prevent hypotension after spinal anesthesia. The action believed to inhibit Bezold-Jarisch reflex. Objective: To assess effect of prophylactic ondansetron on spinal anesthesia induced hypotension among women undergoing elective cesarean section at NMCH, Patna, Bihar, from November 2021 to July 2022. Method: In this prospective study 100 patients with American Society of Anesthesiologists (ASA) status class-II, age≥18 and BMI 18 -30 kg/m2 who underwent cesarean section under spinal anesthesia were included. Prophylactic group (n=50) receive 4mg ondansetron, while Non-prophylactic group (n=50) did not receive ondansetron. The outcomes of the study were the incidence of hypotension, nausea, vomiting and the need of rescue vasopressor. Comparisons of variables between study groups were done using student t test and Chi square test. Significance was determined at P value <0.05. Table and graph were used to show result of the study. Result: The incidence of hypotension is 13(26.5%) in prophylactic group compared to non- prophylactic group 36(75% with (p=007). There was a statistically significant difference in mean systolic blood pressure, mean heart rate and mean arterial pressure between the groups at all-time point with p<0.05. The incidence of nausea and vomiting was higher in non-prophylactic group when compared with prophylactic group with (p=0.003 & 0.001) respectively. There was not significant difference in total need of rescue vasopressor between groups (6.1% in prophylactic and 10.4% in non-prophylactic group with (p=0.17). Conclusion: prophylactic use of 4mg intravenous ondansetron 5 minutes before spinal anesthesia significantly reduces the incidence of hypotension; nausea and vomiting in parturient undergoing elective cesarean section. We recommend the use prophylaxis ondansetron for prevention of spinal anesthesia induced hypotension in parturient undergo elective cesarean section under spinal anesthesia.
Abstract (English)
Background: Hypotension is a common side effect after spinal anesthesia which associates with both maternal and fetal morbidity. Many interventions have been suggested to prevent this clinical problem. A commonly used antiemetic, ondansetron, can be used as an alternative to prevent hypotension after spinal anesthesia. The action believed to inhibit Bezold-Jarisch reflex. Objective: To assess effect of prophylactic ondansetron on spinal anesthesia induced hypotension among women undergoing elective cesarean section at NMCH, Patna, Bihar, from November 2021 to July 2022. Method: In this prospective study 100 patients with American Society of Anesthesiologists (ASA) status class-II, age≥18 and BMI 18 -30 kg/m2 who underwent cesarean section under spinal anesthesia were included. Prophylactic group (n=50) receive 4mg ondansetron, while Non-prophylactic group (n=50) did not receive ondansetron. The outcomes of the study were the incidence of hypotension, nausea, vomiting and the need of rescue vasopressor. Comparisons of variables between study groups were done using student t test and Chi square test. Significance was determined at P value <0.05. Table and graph were used to show result of the study. Result: The incidence of hypotension is 13(26.5%) in prophylactic group compared to non- prophylactic group 36(75% with (p=007). There was a statistically significant difference in mean systolic blood pressure, mean heart rate and mean arterial pressure between the groups at all-time point with p<0.05. The incidence of nausea and vomiting was higher in non-prophylactic group when compared with prophylactic group with (p=0.003 & 0.001) respectively. There was not significant difference in total need of rescue vasopressor between groups (6.1% in prophylactic and 10.4% in non-prophylactic group with (p=0.17). Conclusion: prophylactic use of 4mg intravenous ondansetron 5 minutes before spinal anesthesia significantly reduces the incidence of hypotension; nausea and vomiting in parturient undergoing elective cesarean section. We recommend the use prophylaxis ondansetron for prevention of spinal anesthesia induced hypotension in parturient undergo elective cesarean section under spinal anesthesia.
Files
IJPCR,Vol14,Issue8,Article55.pdf
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Additional details
Dates
- Accepted
-
2022-08-05
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/14/IJPCR,Vol14,Issue8,Article55.pdf
- Development Status
- Active
References
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