Study of Clinicohematological Profile of Haemolytic Anaemia in a District Hospital at Rajkot, Gujarat, India
Authors/Creators
- 1. 2nd year Resident, Department of Pathology, PDU Medical College &Hospital, Rajkot, India
- 2. Professor, Department of Pathology, PDU Medical College & Hospital, Rajkot, India
- 3. Assistant Professor, Department of Pathology, PDU Medical College & Hospital, Rajkot, India
- 4. Professor and Head, Department of Pathology, PDU Medical College & Hospital, Rajkot, India
Description
Introduction: Haemolytic anaemia is a group of disorders that cause significant morbidity in children. Method: A cross sectional study was conducted at district hospital, Rajkot for a period of 1 year. All cases of newly diagnosed and old cases of haemolytic anaemia on follow up were included. A total of 232 cases from all age group were enrolled. Complete demographic and clinical details of all the patients were noted. Classification of the patients was done based on etiologic profile. Separate recording of the etiologic profile was done for subjects with acute and chronic haemolytic anaemia. Clinical profile of all the subjects was noted. Results: While assessing the patients with acute haemolytic anaemia, it was seen that Inherited, Autoimmune, Infections (malaria, dengue, viral hepatitis, enteric fever) and Malignancy, HELLP sx causes were the etiologic profile in 40%, 7%, 12% and 12%, 20% of the patients respectively. While assessing the patients with chronic haemolytic anaemia, it was seen that Inherited (Sickle cell disease/Thalassemia), Blood transfusion complications, Autoimmune conditions, and Bone marrow failure, causes were the etiologic profile in 94%, 0.5%, 1.09% & 1% of the patient respectively. The mean haemoglobin at presentation was 7.39 gm/dl. Massive splenomegaly & hepatomegaly causing discomfort, gall stones were seen in 105 cases. In thalassemia major, 60 cases required frequent transfusions [10-12 per year]. 15 came for less frequent transfusions [6 per year]. Sickle thalassemia & thalassemia intermedia, required one transfusion every 1-2 years. Occasional transfusions were given in sickle cell anaemia also. Conclusion: Haemoglobin electrophoresis remains the main investigation of choice in diagnosis of haemolytic anaemia. Thalassemia major is the most severe among other haemolytic anaemia encountered in this series. The study conclude that the need to improve awareness regarding hemoglobinopathies among population also prenatal screening, blood transfusion policies, chelation. policies to prevent complications in transfusion dependent patients.
Abstract (English)
Introduction: Haemolytic anaemia is a group of disorders that cause significant morbidity in children. Method: A cross sectional study was conducted at district hospital, Rajkot for a period of 1 year. All cases of newly diagnosed and old cases of haemolytic anaemia on follow up were included. A total of 232 cases from all age group were enrolled. Complete demographic and clinical details of all the patients were noted. Classification of the patients was done based on etiologic profile. Separate recording of the etiologic profile was done for subjects with acute and chronic haemolytic anaemia. Clinical profile of all the subjects was noted. Results: While assessing the patients with acute haemolytic anaemia, it was seen that Inherited, Autoimmune, Infections (malaria, dengue, viral hepatitis, enteric fever) and Malignancy, HELLP sx causes were the etiologic profile in 40%, 7%, 12% and 12%, 20% of the patients respectively. While assessing the patients with chronic haemolytic anaemia, it was seen that Inherited (Sickle cell disease/Thalassemia), Blood transfusion complications, Autoimmune conditions, and Bone marrow failure, causes were the etiologic profile in 94%, 0.5%, 1.09% & 1% of the patient respectively. The mean haemoglobin at presentation was 7.39 gm/dl. Massive splenomegaly & hepatomegaly causing discomfort, gall stones were seen in 105 cases. In thalassemia major, 60 cases required frequent transfusions [10-12 per year]. 15 came for less frequent transfusions [6 per year]. Sickle thalassemia & thalassemia intermedia, required one transfusion every 1-2 years. Occasional transfusions were given in sickle cell anaemia also. Conclusion: Haemoglobin electrophoresis remains the main investigation of choice in diagnosis of haemolytic anaemia. Thalassemia major is the most severe among other haemolytic anaemia encountered in this series. The study conclude that the need to improve awareness regarding hemoglobinopathies among population also prenatal screening, blood transfusion policies, chelation. policies to prevent complications in transfusion dependent patients.
Files
IJPCR,Vol16,Issue7,Article258.pdf
Files
(363.6 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:46a9fe4aced99cac8a0770fd1fdc69c3
|
363.6 kB | Preview Download |
Additional details
Dates
- Accepted
-
2024-06-26
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue7,Article258.pdf
- Development Status
- Active
References
- 1. Kliegman MR, Stanton BF, St geme WJ, Shor NF. Nelson text book of pediatrics 20th edition: Elsevier publications; 2016. 2. Weather all DJ, Clegg JB: The thalassemiasyndromes, 4th edition: Oxford Blackwell scientific publications; 2001. 3. Surhone LM, Tennoe MT Henssonow SF, Congenital hemolytic anaemia, Saarbrucken, Germany: VDMV erlog, Dr. Muller; 2010. 4. UNICEF: The state of World's children oxford: Oxford university press; 1996. 5. Yasish HM- Thalassemia: http://www. emedicine. com/PED/topic2229.htm; Accessed 23rd oct 2002. 6. Modell B, Berdoukas V. The clinical approach to Thalassemia: London: Gruns and Stration; 1984. 7. La Nasa G, Caocci G, Argiolu F, Giardini C,Locatelli F, Vacca A, Orofino MG, Piras E, Addari MC, Ledda A, Contu L. Unrelated donor stem cell transplantation in adult patients with thalassemia. Bone marrow transplantation. 2005 Dec 1; 36(11):971-5. 8. Verma IC, Choudhry VP, Jain PK. Prevention of thalassemia: a necessity in India. Indian journal of pediatrics. 1992 Nov 1; 59(6):649- 54. 9. Manglani M, Lokeshwar MR, Vani VG, Bhatia N, Mhaskar V. 'NESTROFT'--an effective screening test for beta thalassemia trait. Indian pediatrics. 1997Aug; 34(8):702-7. 10. Wild BJ, Bain BJ. Investigations of abnormalhemoglobins and thalassemia. In: Lews Sin, Bain BJ,Bates I, Dacie and Lewis practical hematology, 9th Balgir RS. The burden of hemoglobinopathies in India and the challenges ahead. Curr sci. 2000 Dec10; 79(11):1536-47. 11. Balgir RS. Spectrum of hemoglobinopathies in thestate of Orissa, India: a ten years cohort study. JAPI.2005 Dec; 53:1021-6. 12. Balgir RS. The genetic burden of hemoglobinopathies with special reference to community health in India and the challenges ahead. Indian J Hematol Blood Transfus. 2002; 20(1):2-7. 13. Varawalla NY, Old JM, Sarkar R, Venkatesan R, Weatherall DJ. The spectrum of β‐ thalassemia mutations on the Indian subcontinent: the basis for prenatal diagnosis. British journal of haematology. 1991Jun 1; 78(2):242- 7. 14. Shivashankara AR, Jailkhani R, Kini A. Hemoglobinopathies in Dharwad, North Karnataka: Ahospital-based study. J Clin Diagnostic Res. 2008; 2:593-9. 15. Preethi BP, Monika K, Maitreyee DS, Rashmi K. A hospital based study of Hereditary Hemolytic Anaemias in Davanagere district of Karnataka, India. Bangladesh journal of medical science. 2010 Jan 1; 9(3):154.