Biochemical Evaluation of Creatinine and Urea in Patients with Renal Failure Undergoing Hemodialysis in Tertiary Care Hospital at Bhagalpur District, Bihar
- 1. JR 3rd Year, Department of Biochemistry, Jawaharlal Nehru Medical College, Bhagalpur, Bihar
- 2. Associate Professor, Department of Biochemistry, Jawaharlal Nehru Medical College, Bhagalpur, Bihar
Description
One of the slowest developing kidney disorders, renal failure is typically marked by decreased glomerular filtration rate (GRF). Hemodialysis is used as a replacement therapy for renal failure and entails the elimination of the body’s excess toxic fluids and toxic metabolic waste products. In light of this context, the current effort concentrated on evaluating and correlating the importance of several biochemical indicators in blood serum from renal failure patients before and after dialysis. Serum creatinine and urea are two of the many biochemical factors found in blood that are emerging as more accurate indicators of renal failure. Thus, samples from 50 patients with renal failure before and after hemodialysis were included in the analytical part of this investigation to determine the prevalence of creatinine and urea levels. For the detection of creatinine and urea concentrations in human serum, a colorimetrical method utilising a fully automated analyzer was chosen. The concentration of urea was found to be lower than that of creatinine, and the mean values of these two components in the post-dialysis group were lower than those in the pre-dialysis group. Before hemodialysis, the incidence of serum creatinine and urea was noticeably high, and it considerably decreased following hemodialysis. The study found a statistically significant correlation between the levels of urea and creatinine in pre- and post-dialysis blood serum samples from patients with renal failure.
Abstract (English)
One of the slowest developing kidney disorders, renal failure is typically marked by decreased glomerular filtration rate (GRF). Hemodialysis is used as a replacement therapy for renal failure and entails the elimination of the body’s excess toxic fluids and toxic metabolic waste products. In light of this context, the current effort concentrated on evaluating and correlating the importance of several biochemical indicators in blood serum from renal failure patients before and after dialysis. Serum creatinine and urea are two of the many biochemical factors found in blood that are emerging as more accurate indicators of renal failure. Thus, samples from 50 patients with renal failure before and after hemodialysis were included in the analytical part of this investigation to determine the prevalence of creatinine and urea levels. For the detection of creatinine and urea concentrations in human serum, a colorimetrical method utilising a fully automated analyzer was chosen. The concentration of urea was found to be lower than that of creatinine, and the mean values of these two components in the post-dialysis group were lower than those in the pre-dialysis group. Before hemodialysis, the incidence of serum creatinine and urea was noticeably high, and it considerably decreased following hemodialysis. The study found a statistically significant correlation between the levels of urea and creatinine in pre- and post-dialysis blood serum samples from patients with renal failure.
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IJPCR,Vol14,Issue9,Article133.pdf
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Additional details
Dates
- Accepted
-
2022-09-25
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/14/IJPCR,Vol14,Issue9,Article133.pdf
- Development Status
- Active
References
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