A Study to Analyze Serum Alkaline Phosphatase, Total Calcium as Bone Turnover Markers among The Post-Menopausal Women – Case Control Study
Authors/Creators
- 1. Associate Professor, Department of Biochemistry, Government Medical College, Suryapet, Telangana
- 2. Assistant Professor, Department of Biochemistry, Government Medical College, Wanaparthy, Telangana
- 3. Professor, Department of Pathology, Kamineni Institute of Medical Sciences,Narketpally
- 4. Resident, Ayaan Medical College, Moinabad
- 5. Assistant Professor, Department of Pathology, Mallareddy Institute of Medical Sciences, Hyderabad
- 6. Professor, Department of Microbiology, GSL Medical College, Rajahmundry, Andhra Pradesh
Description
Introduction: During menopause, bone resorption slightly exceeds, results in osteoporosis. A study was conducted to evaluate the various hematological parameters in post-menopausal women (PMW) compared to healthy pre menopause controls. Materials and Methods: This was a prospective, case control study conducted in the department of Biochemistry, KMC, Warangal. Study was conducted from June 2012 to December 2014. Study protocol was approved by the institutional ethics committee. Informed oral consent was taken from all the members before considering into the study. Healthy postmenopausal women aged 50 – 70 years without history of smoking, alcohol intake were considered to be test group. Healthy PMW aged 25 – 40 years with no history of smoking and alcohol intake were considered in control group. Random blood samples were collected by venipuncture. Alkaline phosphatase (ALP), total proteins (TP) and albumin were estimated with serum. Chi square test was used to find the statistical significance. Results: Total 30 samples each were included in each group. Age wise, among the groups, statistically there was significant difference. There was raise in serum calcium in test group, statistically there was significant difference. ALP and TP levels were also increased in test group; statistically the difference was significant. Conclusion: Biochemical markers such as ALP, total calcium provide dynamic measure of bone remodeling and thus potentially useful in predicting the course of changes in bone mass and fracture risk in postmenopausal women. Markers also provide a representative index of overall skeletal loss compared to bone marrow density at specific skeletal sites.
Abstract (English)
Introduction: During menopause, bone resorption slightly exceeds, results in osteoporosis. A study was conducted to evaluate the various hematological parameters in post-menopausal women (PMW) compared to healthy pre menopause controls. Materials and Methods: This was a prospective, case control study conducted in the department of Biochemistry, KMC, Warangal. Study was conducted from June 2012 to December 2014. Study protocol was approved by the institutional ethics committee. Informed oral consent was taken from all the members before considering into the study. Healthy postmenopausal women aged 50 – 70 years without history of smoking, alcohol intake were considered to be test group. Healthy PMW aged 25 – 40 years with no history of smoking and alcohol intake were considered in control group. Random blood samples were collected by venipuncture. Alkaline phosphatase (ALP), total proteins (TP) and albumin were estimated with serum. Chi square test was used to find the statistical significance. Results: Total 30 samples each were included in each group. Age wise, among the groups, statistically there was significant difference. There was raise in serum calcium in test group, statistically there was significant difference. ALP and TP levels were also increased in test group; statistically the difference was significant. Conclusion: Biochemical markers such as ALP, total calcium provide dynamic measure of bone remodeling and thus potentially useful in predicting the course of changes in bone mass and fracture risk in postmenopausal women. Markers also provide a representative index of overall skeletal loss compared to bone marrow density at specific skeletal sites.
Files
IJPCR,Vol14,Issue9,Article115.pdf
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Additional details
Dates
- Accepted
-
2022-09-20
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/14/IJPCR,Vol14,Issue9,Article115.pdf
- Development Status
- Active
References
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