Published January 1, 2024
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Long-term in vivo dissolution of thermo- and pH-responsive, 19F magnetic resonance-traceable and injectable polymer implants
Creators
- 1. Institut klinicke a experimentalni mediciny
- 2. Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University, Katerinska 1660/32, Prague 121 08, Czech Republic
- 3. Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovsky square 2, 162 06 Prague, Czech Republic
- 4. Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Hlavova 8, Prague, 128 00, Czech Republic
Description
F-19 magnetic resonance (F-19 MR) tracers stand out for their wide range of applications in experimental and clinical medicine, as they can be precisely located in living tissues with negligible fluorine background. This contribution demonstrates the long-term dissolution of multiresponsive fluorinated implants designed for prolonged release. Implants were detected for 14 (intramuscular injection) and 20 (subcutaneous injection) months by F-19 MR at 4.7 T, showing favorable MR relaxation times, biochemical stability, biological compatibility and slow, long-term dissolution. Thus, polymeric implants may become a platform for long-term local theranostics.
Notes
This work was supported by the Czech Science Foundation
[grant number 22-02836S]; the Ministry of Health of the Czech
Republic– conceptual development of research organization
(Institute for Clinical and Experimental Medicine- IKEM
[IN00023001]); the National Institute for Research of Metabolic
and Cardiovascular Diseases (Programme EXCELES, project no.
LX22NPO5104)-Funded by the European Union—Next
Generation EU. Financial support from the Ministry of Educa
tion, Youth and Sports of the Czech Republic [grant number
INTER COST LTC19032] is gratefully acknowledged. We would
like to thank V´ ıtek Hofˇ stetr for preparing the graphical abstract.
The authors thank Carlos V. Melo for editing the manuscript.
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- Has metadata
- 38868824 (PMID)
- Is part of
- 2516-0230 (ISSN)
- 2516-0230 (ISSN)
- References
- 10.1039/d4na00212a (DOI)