Published July 31, 2024
| Version https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue7,Article223.pdf
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Identifying Obesity Subtypes, Related Biomarkers, and Heterogeneity
Creators
- 1. Assistant Professor, Department of General Medicine, Swaminarayan Institute of Medical Sciences & Research, Kalol, Gandhinagar
Description
Globally, obesity is a severe medical condition that requires novel strategies and acknowledged international agreement to treat illnesses that result in morbidity. Examining the diverse relationships between the different adult obesity phenotypes was the goal of this review. To distinguish between biomarkers, an analysis was conducted on proteins and related genes in each group. There is currently no clear consensus in nomenclature, despite the fact that a number of terminologies are used for classification and characterisation within this disorder. The most important categories that were examined were sarcopenic obesity, metabolically abnormal, normal weight, metabolically healthy obese, and metabolically abnormal obese. These phenotypes don’t specify specific genotypes, epigenetic gene regulation, or inflammatory protein combinations. Numerous other genes have been related to obesity, yet it is still worthwhile to check. Since there are no meaningful biomarkers, the outcomes of those for diagnosis are not very predictive. It is critical to reach agreement on the nomenclature and attributes applied to obesity subtypes. Finding certain molecular biomarkers is also necessary for more accurate detection of obesity subtypes.
Abstract (English)
Globally, obesity is a severe medical condition that requires novel strategies and acknowledged international agreement to treat illnesses that result in morbidity. Examining the diverse relationships between the different adult obesity phenotypes was the goal of this review. To distinguish between biomarkers, an analysis was conducted on proteins and related genes in each group. There is currently no clear consensus in nomenclature, despite the fact that a number of terminologies are used for classification and characterisation within this disorder. The most important categories that were examined were sarcopenic obesity, metabolically abnormal, normal weight, metabolically healthy obese, and metabolically abnormal obese. These phenotypes don’t specify specific genotypes, epigenetic gene regulation, or inflammatory protein combinations. Numerous other genes have been related to obesity, yet it is still worthwhile to check. Since there are no meaningful biomarkers, the outcomes of those for diagnosis are not very predictive. It is critical to reach agreement on the nomenclature and attributes applied to obesity subtypes. Finding certain molecular biomarkers is also necessary for more accurate detection of obesity subtypes.
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Additional details
Dates
- Accepted
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2024-06-26
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue7,Article223.pdf
- Development Status
- Active
References
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