Commentary on Inherited and Acquired Thrombophilia and Infertility in Infertile Women

The effect that inherited and acquired thrombophilias have on embryonic vascularization and implantation is controversial. Therefore, protein S deficiency (DPS), protein C deficiency (DPC), antithrombin (DAT), Factor V Leiden mutation (FVL), prothrombin mutation G20210A, anticardiolipin antibody (ACA), lupus anticoagulant (LA), and anti-β2-glycoprotein I antibody are evaluated for infertility patients. In a convenience sample crosssectional study of 130 infertile white Brazilian women with 260 fertile white Brazilian women controls, significant differences were found between infertile and fertile white Brazilian women for prevalence of ACA (p<0.0001; Odds ratio [OR] = 3.61), DPC (p = 0.0458; OR = 0.97), DPS (p < 0.0001; OR = 1.70), and DAT (p = 0.0171; OR = 1.20). Significant differences were not found for FVL, prothrombin mutation G20210A, or LA. This study did not evaluate anti-β2-glycoprotein I. Some of the cited literature supported the authors’ findings for ACA. The authors suggested that prospective studies are needed to confirm this data.