Study of Cases of Multi-Drug Resistant Tuberculosis in Cervical Tuberculous Lymphadenitis
Creators
- 1. Associate Professor in ENT, Narendra Modi Medical College, Ahmedabad
- 2. 3rd Year Resident in ENT, Narendra Modi Medical College
- 3. Assistant Professor in ENT, Narendra Modi Medical College
- 4. Professor and HOD in ENT, Narendra Modi Medical College
- 5. Senior Resident in ENT, Swaminarayan institute of medical science
- 6. Senior Resident in ENT, Narendra Modi Medical College
Description
Introduction: Lymph nodes are organs which are present in regions of neck, chest, abdomen, and groin. Neck consists of 300 lymph nodes nearly 2/3rd of overall lymph nodes that are there in body. Lymphadenopathy is course of disease and this course involves lymph nodes that are anomalous in uniformity and dimension. Lymphadenitis relates to lymphadenopathies which are caused because of inflammatory pathology. Among the different infective and inflammatory conditions of cervical lymphadenopathy, the commonest cause is tuberculous lymphadenitis. It is a commonest form of extra-pulmonary tuberculosis since tuberculosis is chief health-related problem because of social and economic issues. Tuberculosis is a disease of great antiquity and has even been found in Egyptian mummies. Multidrug-resistant tuberculosis (MDR-TB) is tuberculosis due to organisms which show resistance to both isoniazid and rifampicin, with or without resistance to other anti-TB drugs. Objective: To determine incidence of Drug resistant Tuberculosis in cervical tuberculous lymphadenitis and to determine response of treatment of Drug resistant Tuberculosis. Materials and Methods: It is an observational, prospective hospital based study in 52 patients carried out at Sheth L.G Hospital in Ahmadabad in 2 years span. Proper history and clinical evaluation were done. According to the new NTEP guidelines, the pus of each of these patients included in the study were sent for CBNAAT in falcon tube. The expert MTB/RIF technique was performed in the machine kept at Microbiology Department of Narendra Modi Medical College. Results regarding sensitivity of bacilli against rifampicin are produced using this technique within 2 hours. Results thus obtained, were analysed. Results: There were 52 cases of cervical tuberculous lymphadenopathy in which 14 cases were of drug-resistant tuberculosis. In the present study of gene Xpert, Rifampicin sensitive Tuberculosis which includes Drug sensitive tuberculosis was detected in 73.15% while Rifampicin resistance in 26.9%. Out of 14 cases of drug resistant tuberculosis, 85.71% cases showed treatment success, 7.14% cases were defaulters, 7.14% were lost to follow up. Conclusion: The emergence of MDR-TB has been attributed to factors such as nonadherence to treatment, inappropriate treatment regimens, drug malabsorption, poor drug quality, lack of health education, delay in initiation of treatment, resistance to additional drugs and a poor health infrastructure for effective delivery of treatment.
Abstract (English)
Introduction: Lymph nodes are organs which are present in regions of neck, chest, abdomen, and groin. Neck consists of 300 lymph nodes nearly 2/3rd of overall lymph nodes that are there in body. Lymphadenopathy is course of disease and this course involves lymph nodes that are anomalous in uniformity and dimension. Lymphadenitis relates to lymphadenopathies which are caused because of inflammatory pathology. Among the different infective and inflammatory conditions of cervical lymphadenopathy, the commonest cause is tuberculous lymphadenitis. It is a commonest form of extra-pulmonary tuberculosis since tuberculosis is chief health-related problem because of social and economic issues. Tuberculosis is a disease of great antiquity and has even been found in Egyptian mummies. Multidrug-resistant tuberculosis (MDR-TB) is tuberculosis due to organisms which show resistance to both isoniazid and rifampicin, with or without resistance to other anti-TB drugs. Objective: To determine incidence of Drug resistant Tuberculosis in cervical tuberculous lymphadenitis and to determine response of treatment of Drug resistant Tuberculosis. Materials and Methods: It is an observational, prospective hospital based study in 52 patients carried out at Sheth L.G Hospital in Ahmadabad in 2 years span. Proper history and clinical evaluation were done. According to the new NTEP guidelines, the pus of each of these patients included in the study were sent for CBNAAT in falcon tube. The expert MTB/RIF technique was performed in the machine kept at Microbiology Department of Narendra Modi Medical College. Results regarding sensitivity of bacilli against rifampicin are produced using this technique within 2 hours. Results thus obtained, were analysed. Results: There were 52 cases of cervical tuberculous lymphadenopathy in which 14 cases were of drug-resistant tuberculosis. In the present study of gene Xpert, Rifampicin sensitive Tuberculosis which includes Drug sensitive tuberculosis was detected in 73.15% while Rifampicin resistance in 26.9%. Out of 14 cases of drug resistant tuberculosis, 85.71% cases showed treatment success, 7.14% cases were defaulters, 7.14% were lost to follow up. Conclusion: The emergence of MDR-TB has been attributed to factors such as nonadherence to treatment, inappropriate treatment regimens, drug malabsorption, poor drug quality, lack of health education, delay in initiation of treatment, resistance to additional drugs and a poor health infrastructure for effective delivery of treatment.
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IJPCR,Vol15,Issue1,Article92.pdf
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Additional details
Dates
- Accepted
-
2022-12-30
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue1,Article92.pdf
- Development Status
- Active
References
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