Comparative Analysis of Various Antibiotics in Surgical Site Infections Caused by Various Causative Microorganisms
Authors/Creators
- 1. Associate Professor, Department of Microbiology, D. Y. Patil University School of Medicine, Nerul, Navi Mumbai, India
- 2. Ex Resident, Department of Microbiology, D. Y. Patil University School of Medicine, Nerul, Navi Mumbai, India
- 3. Professor & Head of Department, Department of Microbiology, D. Y. Patil University School of Medicine, Nerul, Navi Mumbai, India
Description
Introduction: Surgical Site Infections could involve an organ or bodily space, a shallow or deep incisional infection, or both. The third most frequently reported nosocomial infection in the hospital population, postoperative SSI is one of the most frequent issues for patients, who receive cesarean sections. The prevalence of postoperative SSI varies significantly across procedures, hospitals, doctors, patients, and geographical locales. It makes things more difficult worldwide including Ethiopia (21%), India (2.85%), and Nigeria (7-9.6%). Aims and Objectives: To analyze the efficacy in terms of sensitivity and resistance of various antibiotics in the management of surgical site infection with respect to the causal organisms. Methods: This is a prospective study conducted on 430 patients. In addition, out of 430 patients were operated on for clean surgeries, clean-contaminated surgeries, contaminated surgeries. The postoperative wound discharge was collected and bacterial pathogens were isolated. The plates were incubated at 37°C overnight for 24-48 hours. A hand lens was used whenever necessary to inspect all plate cultures. Results: The study found that a total of 430 patients were studied for the development of Post-Operative Surgical Site Infection. It has been found that 32 out of 430 cases showed growth of 36 isolates, with overall post-operative surgical site infection rate of 7.47%. The study found 100% resistance is present in Klebsiella, E. coli with ampicillin while amikacin and gentamicin have 100% resistance with Acinetobacter. Conclusion: The study has shown sensitivity and resistance of different antibiotics with different micro-organisms and have brought forward an image of epidemiological view of surgical site infection, all of which, would contribute in the postoperative management efficiently.
Abstract (English)
Introduction: Surgical Site Infections could involve an organ or bodily space, a shallow or deep incisional infection, or both. The third most frequently reported nosocomial infection in the hospital population, postoperative SSI is one of the most frequent issues for patients, who receive cesarean sections. The prevalence of postoperative SSI varies significantly across procedures, hospitals, doctors, patients, and geographical locales. It makes things more difficult worldwide including Ethiopia (21%), India (2.85%), and Nigeria (7-9.6%). Aims and Objectives: To analyze the efficacy in terms of sensitivity and resistance of various antibiotics in the management of surgical site infection with respect to the causal organisms. Methods: This is a prospective study conducted on 430 patients. In addition, out of 430 patients were operated on for clean surgeries, clean-contaminated surgeries, contaminated surgeries. The postoperative wound discharge was collected and bacterial pathogens were isolated. The plates were incubated at 37°C overnight for 24-48 hours. A hand lens was used whenever necessary to inspect all plate cultures. Results: The study found that a total of 430 patients were studied for the development of Post-Operative Surgical Site Infection. It has been found that 32 out of 430 cases showed growth of 36 isolates, with overall post-operative surgical site infection rate of 7.47%. The study found 100% resistance is present in Klebsiella, E. coli with ampicillin while amikacin and gentamicin have 100% resistance with Acinetobacter. Conclusion: The study has shown sensitivity and resistance of different antibiotics with different micro-organisms and have brought forward an image of epidemiological view of surgical site infection, all of which, would contribute in the postoperative management efficiently.
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IJPCR,Vol15,Issue1,Article34.pdf
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Additional details
Dates
- Accepted
-
2022-12-11
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue1,Article34.pdf
- Development Status
- Active
References
- 1. Mangram, A. J., Horan, T. C., Pearson, M. L., Silver, L. C., & Jarvis, W. R. Guideline for Prevention of Surgical Site Infection, Centers for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee. American Journal of Infection Control, 1999; 27(2): 97–132; quiz 133-134; discussion 96. 2. Weigelt J. A., Lipsky B. A., Tabak Y. P., Derby K. G., Kim M., & Gupta V. Surgical site infections: Causative pathogens and associated outcomes. American Journal of Infection Control, 2010; 38(2): 112–120. 3. Kotisso B., & Aseffa A. Surgical wound infection in a teaching hospital in Ethiopia. East African Medical Journal. 1998; 75(7): 402–405. 4. Jido T., & Garba I. Surgical-site infection following cesarean section in Kano, Nigeria. Annals of Medical and Health Sciences Research. 2012; 2(1):33. 5. Anderson D. J., & Kaye K. S. Staphylococcal Surgical Site Infections. Infectious Disease Clinics of North America. 2009; 23(1): 53– 72. 6. Njoku C. O., & Njoku A. N. Microbiological Pattern of Surgical Site Infection Following Caesarean Section at the University of Calabar Teaching Hospital. Open Access Macedonian Journal of Medical Sciences. 2019; 7(9): 1430–1435. 7. Hohmann C., Eickhoff C., Radziwill R., & Schulz M. Adherence to guidelines for antibiotic prophylaxis in surgery patients in German hospitals: a multicentre evaluation involving pharmacy interns. Infection. 2011; 40(2): 131 –137. 8. Owens C. D., & Stoessel K Surgical site infections: epidemiology, microbiology and prevention. The Journal of Hospital Infection, 2008; 70 Suppl 2: 3–10. 9. Pradhan G. B. N., & Agrawal J. Comparative study of post operative wound infection following emergency lower segment caesarean section with and without the topical use of fusidic acid. Nepal Medical College Journal: NMCJ, 2009; 11(3): 189–191. 10. Ahmed M. Prevalence of nosocomial wound infection among postoperative patients and antibiotics patterns at teaching hospital in Sudan. North American Journal of Medical Sciences, 2012; 4(1): 29. 11. Mulu W., Kibru G., Beyene G., & Damtie M. Postoperative Nosocomial Infections and Antimicrobial Resistance Pattern of Bacteria Isolates among Patients Admitted at Felege Hiwot Referral Hospital, Bahirdar, Ethiopia. Ethiopian Journal of Health Sciences, 2012; 22(1): 7–18. 12. Ballus J., Lopez-Delgado J. C., Sabater-Riera J., Perez-Fernandez X. L., Betbese A. J., & Roncal J. A. Surgical site infection in critically ill patients with secondary and tertiary peritonitis: epidemiology, microbiology and influence in outcomes. BMC Infectious Diseases, 2015; 15(1).13. Kotisso B., & Aseffa A. Surgical wound infection in a teaching hospital in Ethiopia. East African Medical Journal, 1998; 75(7): 402–405. 14. Anderson D. J., & Kaye K. S. Staphylococcal Surgical Site Infections. Infectious Disease Clinics of North America. 2009; 23(1), 53–72. 15. Merrer J., Girou E., Lortat-Jacob A., Montravers P., & Lucet, J.C. Surgical Site Infection After Surgery to Repair Femoral Neck Fracture: A French Multicenter Retrospective Study. Infection Control & Hospital Epidemiology. 2007; 28(10): 116 9– 1174. 16. Aggarwal A, Khanna S, Arora U, Devi P. Correlation of beta-lactamase production/methicillin resistance and phage pattern of Staphylococcus aureus. Indian J Med Sci. 2001;55(5): 253–56. 17. Eagye KJ, Kim A, Laohavaleeson S, Kuti JL, Nicolau DP. Surgical site infections: does inadequate antibiotic therapy affect patient outcomes? Surg Infect (Larchmt) 2009;10(4):323–31. 18. Sohn AH, Parvez FM, Vu T, Hai HH, Bich NN, Le Thu TA. Prevalence of surgical-site infections and patterns of antimicrobial use in a large tertiarycare hospital in Ho Chi Minh City, Vietnam. Infect Control Hosp Epidemiol. 2002;23(7):382–87. 19. Isibor OJ, Oseni A, Eyaufe A. Incidence of aerobic bacteria and Candida albicans in postoperative wound infections. Afr J microbial Res. 2008;2:288–91. 20. Fletcher N, Sofianos D, Berkes MB, Obremskey WT. Prevention of perioperative infection. J Bone Joint Surg Am. 2007;89(7):1605–18. 21. Kaye KS, Anderson DJ, Sloane R, Chen LF, Choi Y, Link K, et al. The effect of surgical site infection on older operative patients. J Am Geriatr Soc. 2009;57(1):46–54. 22. Eagye KJ, Kim A, Laohavaleeson S, Kuti JL, Nicolau DP. Surgical site infections: does inadequate antibiotic therapy affect patient outcomes? SurgInfect (Larchmt) 2009;10(4):323– 31. 23. Kownhar H, Shankar EM, Vignesh R, Sekar R, Velu V, Rao UA. High isolation rate of Staphylococcus aureus from surgical site infections in an Indian hospital. J Antimicrob Chemother. 2008;61:758–60. 24. Isibor OJ, Oseni A, Eyaufe A. Incidence of aerobic bacteria and Candida albicans in postoperative wound infections. Afr J microbial Res. 2008;2:288–91. 25. Satyanarayana V, Prashanth HV, Basavaraj B, Kavyashree AN. Study of surgical site infections in abdominal surgeries. J Clin Diagn Res. 2011;5:93 5–39 26. Khan AKA, Rashed MR, Banu G. A Study on the Usage Pattern of antimicrobial agents for the prevention of surgical site infections (ssis) in a tertiary care teaching hospital. J Clin Diagn Res. 2013;7(4):671–74. 27. Demir H., & Bozyel E. Investigation of the Relationship between Mindful Eating Behavior and Anthropometric Measurements of Individuals Applying to a Nutrition And Diet Policlinic. Journal of Medical Research and Health Sciences, 2022; 5(1): 1636– 1646.