A Study to Investigate the Correlation between Vitamin D and Cellular Senescence As Assessed by the Telomerase Enzyme in Individuals with PreHTN: A Retrospective Study
Authors/Creators
- 1. Tutor, Department of Physiology, Jawaharlal Nehru Medical College, Bhagalpur, Bihar, India
- 2. Assistant Professor, Department of Physiology, Jawaharlal Nehru Medical College, Bhagalpur, Bihar, India
- 3. Professor and HOD, Department of Physiology, Jawaharlal Nehru Medical College, Bhagalpur, Bihar, India
Description
Aim: The aim of the present study was to explore the link between Vitamin D and cellular senescence measured with the enzyme telomerase in pre-HTN. Methods: The present study was conducted from in the Department of Physiology, Jawaharlal Nehru Medical College, Bhagalpur, Bihar, India for two years . Inclusion criteria for the pre- hypertensive group (pre-HTN) (n =50) were both genders between 18 and 25 years of age with SBP between 120 and 139 mmHg and DBP between 80 and 89 mmHg in apparently healthy individuals. The controls (n = 50) population were healthy individuals with 18– 25 years of age with SBP between 100 and 119 mmHg and DBP between 60 and 79 mmHg. Results: The study population included 100 apparently healthy individuals. 50 were pre- hypertensive with the age of 22.58±1.56 and the age of controls was 18.82±1.22. Out of 100, 27 males, 23 females in pre- HTN group and 26 males, 24 females were in the control group. A significant difference was not found between-group differences in height and waist-hip ratio. However, pre- HTN group subject’s BMI (P < 0.001) and weight (P < 0.001) was more compared to controls. In pre-HTN group, significantly higher HR (P < 0.001), SBP (P < 0.001), DBP (P < 0.001), MAP (P < 0.001), and RPP (P < 0.001) were seen when compared to controls. No significant difference was seen in PP but it was slightly high in pre-HTN group and negatively associated with Vitamin D. High telomerase levels have correlation with waist-hip ratio, SBP, DBP, MAP, and RPP but no significant correlation was seen with BMI, HR, and PP. Conclusion: It can be concluded that reduced Vitamin D levels in pre-HTN may cause derangements of cardiovascular homeostatic mechanism, enhance the speed of cellular senescence measured by telomerase.
Abstract (English)
Aim: The aim of the present study was to explore the link between Vitamin D and cellular senescence measured with the enzyme telomerase in pre-HTN. Methods: The present study was conducted from in the Department of Physiology, Jawaharlal Nehru Medical College, Bhagalpur, Bihar, India for two years . Inclusion criteria for the pre- hypertensive group (pre-HTN) (n =50) were both genders between 18 and 25 years of age with SBP between 120 and 139 mmHg and DBP between 80 and 89 mmHg in apparently healthy individuals. The controls (n = 50) population were healthy individuals with 18– 25 years of age with SBP between 100 and 119 mmHg and DBP between 60 and 79 mmHg. Results: The study population included 100 apparently healthy individuals. 50 were pre- hypertensive with the age of 22.58±1.56 and the age of controls was 18.82±1.22. Out of 100, 27 males, 23 females in pre- HTN group and 26 males, 24 females were in the control group. A significant difference was not found between-group differences in height and waist-hip ratio. However, pre- HTN group subject’s BMI (P < 0.001) and weight (P < 0.001) was more compared to controls. In pre-HTN group, significantly higher HR (P < 0.001), SBP (P < 0.001), DBP (P < 0.001), MAP (P < 0.001), and RPP (P < 0.001) were seen when compared to controls. No significant difference was seen in PP but it was slightly high in pre-HTN group and negatively associated with Vitamin D. High telomerase levels have correlation with waist-hip ratio, SBP, DBP, MAP, and RPP but no significant correlation was seen with BMI, HR, and PP. Conclusion: It can be concluded that reduced Vitamin D levels in pre-HTN may cause derangements of cardiovascular homeostatic mechanism, enhance the speed of cellular senescence measured by telomerase.
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IJTPR,Vol14,Issue2,Article49.pdf
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Additional details
Dates
- Accepted
-
2024-02-21
Software
References
- 1. Hyppönen E, Boucher BJ. Adiposity, vitamin D requirements, and clinical implications for obesity-related metabolic abnormalities. Nutrition Reviews. 2018 Sep 1;76(9):678-92. 2. Ogrodnik M, Zhu YI, Langhi LG, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O. Obesity-induced cellular senescence drives anxiety and impairs neurogenesis. Cell metabolism. 2019 May 7;29(5):1061-77. 3. Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z, Li R, Houston DK, Wood AR. Causal relationship between obesity and vitamin D status: bidirectional Mendelian randomization analysis of multiple cohorts. PLoS medicine. 2013 Feb 5;10(2): e1001383. 4. Vranić L, Mikolašević I, Milić S. Vitamin D deficiency: consequence or cause of obesity? Medicina. 2019 Aug 28;55(9):541. 5. Laing ST, Smulevitz B, Vatcheva KP, Rahbar MH, Reininger B, McPherson DD, McCormick JB, Fisher-Hoch SP. Subclinical atherosclerosis and obesity phenotypes among Mexican Americans. Journal of the American Heart Association. 2015 Mar 18;4(3):e001540. 6. Legarth C, Grimm D, Krueger M, Infanger M, Wehland M. Potential beneficial effects of vitamin d in coronary artery disease. Nutrients. 2019 Dec 30;12(1):99. 7. Wimalawansa SJ. Vitamin D and cardiovascular diseases: Causality. The Journal of steroid biochemistry and molecular biology. 2018 Jan 1; 175:29-43. 8. Rai V, Agrawal DK. Role of vitamin D in cardiovascular diseases. Endocrinology and Metabolism Clinics. 2017 Dec 1;46(4):1039-59. 9. Ortega FB, Lee DC, Katzmarzyk PT, Ruiz JR, Sui X, Church TS, Blair SN. The intriguing metabolically healthy but obese phenotype: cardiovascular prognosis and role of fitness. European heart journal. 2013 Feb 1;34(5):389- 97. 10. Siasos G, Tousoulis D, Oikonomou E, Maniatis K, Kioufis S, Zaromitidou M, Kokkou E, Mazaris S, Konsola T, Stefanadis C. Vitamin D serum levels are associated with cardiovascular outcome in coronary artery disease. European Heart Journal. 2013 Aug 1;34(suppl_1): P2486. 11. Lai H, Fishman EK, Gerstenblith G, Brinker JA, Tong W, Bhatia S, Detrick B, Lai S. Vitamin D deficiency is associated with significant coronary stenoses in asymptomatic African American chronic cocaine users. International journal of cardiology. 2012 Jul 12;158(2):211- 6. 12. Fernández-Alvira JM, Fuster V, Dorado B, Soberón N, Flores I, Gallardo M, Pocock S, Blasco MA, Andrés V. Short telomere load, telomere length, and subclinical atherosclerosis: the PESA study. Journal of the American College of Cardiology. 2016 May 31;67(21):2467- 76. 13. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo Jr JL, Jones DW, Materson BJ, Oparil S, Wright Jr JT, Roccella EJ. Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. hypertension. 2003 Dec 1;42(6):1206-52. 14. Mittal BV, Singh AK. Hypertension in the developing world: challenges and opportunities. American Journal of Kidney Diseases. 2010 Mar 1;55(3):590-8. 15. Holick MF. Vitamin D: important for prevention of osteoporosis, cardiovascular heart disease, type 1 diabetes, autoimmune diseases, and some cancers. Southern medical journal. 2005 Oct 1;98(10):1024-8. 16. Colley RC, Garriguet D, Janssen I, Craig CL, Clarke J, Tremblay MS. Physical activity of Canadian adults: accelerometer results from the 2007 to 2009 Canadian Health Measures Survey. Health reports. 2011 Mar 1;22(1):7. 17. Warburton DE, Charlesworth S, Ivey A, Nettlefold L, Bredin SS. A systematic review of the evidence for Canada's Physical Activity Guidelines for Adults. International journal of behavioral nutrition and physical activity. 2010 Dec;7(1):1-220. 18. Elmer PJ, Obarzanek E, Vollmer WM, Simons-Morton D, Stevens VJ, Young DR, Lin PH, Champagne C, Harsha DW, Svetkey LP, Ard J. Effects of comprehensive lifestyle modification on diet, weight, physical fitness, and blood pressure control: 18-month results of a randomized trial. Annals of internal medicine. 2006 Apr 4;144(7):485-95. 19. Hosseinpanah F, Yarjanli M, Sheikholeslami F, Heibatollahi M, Eskandary PS, Azizi F. Associations between vitamin D and cardiovascular outcomes; Tehran Lipid and Glucose Study. Atherosclerosis. 2011 Sep 1;218(1):238-42. 20. Vitamin D. deficiency. Holick MF. N Engl J Med. 2007; 357:266-81. 21. Lucas RM, Ponsonby AL, Dear K, Valery PC, Taylor B, Van Der Mei I, McMichael AJ, Pender MP, Chapman C, Coulthard A, Kilpatrick TJ. Vitamin D status: multifactorial contribution of environment, genes and other factors in healthy Australian adults across a latitude gradient. The Journal of steroid biochemistry and molecular biology. 2013 Jul 1;136: 300-8. 22. Holick MF. Environmental factors that influence the cutaneous production of vitamin D. The American journal of clinical nutrition. 1995 Mar 1;61(3): S638-45. 23. Pludowski P, Holick MF, Pilz S, Wagner CL, Hollis BW, Grant WB, Shoenfeld Y, Lerchbaum E, Llewellyn DJ, Kienreich K, Soni M. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality—a review of recent evidence. Autoimmunity reviews. 2013 Aug 1;12(10):976-89. 24. Amer M, Qayyum R. Relationship between 25-hydroxyvitamin D and all-cause and cardiovascular disease mortality. The American journal of medicine. 2013 Jun 1;126(6):509- 14. 25. Zhao G. Ford eS, li C, Kris-etherton PM, etherton td, balluz lS. Independent associations of serum concentrations of 25-hydroxyvitamin d and parathyroid hormone with blood pressure among uS adults. J hypertens. 2010; 28:1821-8. 26. Forman JP, Giovannucci E, Holmes MD, Bischoff-Ferrari HA, Tworoger SS, Willett WC, Curhan GC. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension. 2007 May 1;49(5):1063-9. 27. Scragg R, Sowers M, Bell C. Serum 25- hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey. American journal of hypertension. 2007 Jul 1;20(7):713-9. 28. Richards JB, Valdes AM, Gardner JP, Paximadas D, Kimura M, Nessa A, Lu X, Surdulescu GL, Swaminathan R, Spector TD, Aviv A. Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. The American journal of clinical nutrition. 2007 Nov 1;86(5):1 420-5. 29. von Zglinicki T. Telomeres and replicative senescence: is it only length that counts? Cancer letters. 2001 Jul 26;168(2):111-6. 30. Von Zglinicki T. Oxidative stress shortens telomeres. Trends in biochemical sciences. 20 02 Jul 1;27(7):339-44. 31. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Experimental cell research. 1965 Mar 1;37(3):614-36.