Assessment of Association of Hypocalcemia with Severity of Disease in Patients with Dengue Fever in a Tertiary Care Hospital
Creators
- 1. Professor, Department of General Medicine, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik-422003, India
- 2. Junior Resident-3, Department of General Medicine, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik-422003, India
- 3. Final Year MBBS, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik-422003, India
- 4. Intern, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik422003, India
- 5. Professor and Head, Department of Pharmacology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik-422003, India
Description
Introduction: Dengue hemorrhagic fever (DHF) is a major cause of morbidity and mortality in tropical regions. Serum free calcium (Ca2+) is known to be important in cardiovascular function. We therefore evaluated association between serum Ca2+ level and severity of dengue. Methodology: A cross-sectional study was carried out at a tertiary care private hospital in India. A probable case of dengue was diagnosed and classified according to World Health Organization criteria and confirmed by either IgM antibody, PCR, or NS1 antigen detection. Socio-demographic details were collected using an interviewer-administered questionnaire. Results: The sample size was 130. The mean age was 32.1 years, and the majority were males (n = 78, 53.8%). DHF was diagnosed in 69 patients (53%). Mean serum Ca2+ level of the study population was 1.05 mmol/L (range 0.72–1.22). Mean serum Ca2+ was significantly higher in patients with dengue fever (DF) (1.04 mmol/L) than in those with DHF (1.01 mmol/L) (p < 0.05). Prevalence of hypocalcemia in DHF and DF patients was 86.9% (n = 60) and 29.7% (n = 11), respectively (p < 0.05). Conclusions: Serum Ca2+ levels may significantly correlated with dengue severity. Serum Ca2+ levels were significantly lower and hypocalcemia was more prevalent in patients with DHF than in patients with DF. Further studies are required to determine whether hypocalcemia can be utilized as a prognostic indicator and to evaluate effectiveness of calcium therapy in prevention of dengue complications in the patients.
Abstract (English)
Introduction: Dengue hemorrhagic fever (DHF) is a major cause of morbidity and mortality in tropical regions. Serum free calcium (Ca2+) is known to be important in cardiovascular function. We therefore evaluated association between serum Ca2+ level and severity of dengue. Methodology: A cross-sectional study was carried out at a tertiary care private hospital in India. A probable case of dengue was diagnosed and classified according to World Health Organization criteria and confirmed by either IgM antibody, PCR, or NS1 antigen detection. Socio-demographic details were collected using an interviewer-administered questionnaire. Results: The sample size was 130. The mean age was 32.1 years, and the majority were males (n = 78, 53.8%). DHF was diagnosed in 69 patients (53%). Mean serum Ca2+ level of the study population was 1.05 mmol/L (range 0.72–1.22). Mean serum Ca2+ was significantly higher in patients with dengue fever (DF) (1.04 mmol/L) than in those with DHF (1.01 mmol/L) (p < 0.05). Prevalence of hypocalcemia in DHF and DF patients was 86.9% (n = 60) and 29.7% (n = 11), respectively (p < 0.05). Conclusions: Serum Ca2+ levels may significantly correlated with dengue severity. Serum Ca2+ levels were significantly lower and hypocalcemia was more prevalent in patients with DHF than in patients with DF. Further studies are required to determine whether hypocalcemia can be utilized as a prognostic indicator and to evaluate effectiveness of calcium therapy in prevention of dengue complications in the patients.
Files
IJPCR,Vol15,Issue2,Article188.pdf
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Additional details
Dates
- Accepted
-
2023-02-24
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue2,Article188.pdf
- Development Status
- Active
References
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