Hyaluronic Acid-Coated Camptothecin Nanocrystals for Targeted Drug Delivery to Enhance Anticancer Efficacy

An abnormally developing tumour that starts out as a localised illness that may expand and affect other organs or critical functions is what causes cancer. Cancer is the result of unchecked cell proliferation. Cancer remains, causing many deaths every year. continues to be among the world's worst illnesses. The purpose of this research was to provide a summary of previously released papers about current developments in the discovery of anticancer drugs. Chemotherapy involves delivering drugs to the tumor and is very effective in treating cancer. Anti-inflammatory drugs such as camptothecin (CPT) are important for liver and tumor treatment. This study successfully developed novel HA-coated CPT nanocrystals to specifically deliver hydrophobic CPT to tumors using a precipitation method which was inspired by the unique CD44 binding potential of hyaluronic acid (HA). These nanocrystals of CPT coated with HA.HA may be used as a ligand to create tailored nanovehicles for potential use in cancer treatment in the future. Our goal in this review is to give a summary of several in vitro and in vivo research that address this possibility.