Published February 28, 2023 | Version https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue2,Article76.pdf
Journal article Open

One Year Cross-Sectional Study of Maternal and Perinatal Outcome in Severe Pre-Eclampsia

  • 1. Senior Resident, Department of Obstetrics and Gynaecology, Sri Krishna Medical College and Hospital, Muzaffarpur, Bihar
  • 2. Associate Professor, Department of Obstetrics and Gynaecology, Sri Krishna Medical College and Hospital, Muzaffarpur, Bihar

Description

Background: Pre-eclampsia is a major global contributor to maternal and neonatal morbidity and mortality. The majority of referrals to tertiary care centres are for pre-eclampsia. This study’s goal is to determine how patients with severe pre-eclampsia will fare maternally and perinatally. Methods: The Department of Obstetrics and Gynecology at SKMCH, Muzaffarpur, Bihar, conducted this prospective study from January 2022 to December 2022. There were 240 women in total who had developed severe pre-eclampsia after 34 weeks of pregnancy. Women with a history of many pregnancies, anaemia, pre-existing hypertension, epilepsy, diabetes, or vascular or renal causes were not allowed to participate. After a thorough history, examination, and investigation, patients were handled in accordance with the established protocol. The preferred medication for treating convulsions was magnesium sulphate, while labetalol or oral nefidipine was used to regulate blood pressure. Results: Out of 240 occurrences of severe pre-eclampsia, most (70%) included women in their 20s and 30s who were also mostly primigravida (79.16%). The most frequent presenting symptom in the current study was edoema (80.8%), which was followed by headache (40.8%). 56.6% of women with severe pre-eclampsia gave birth naturally while 43.5% underwent caesarean sections, most often as a result of a botched induction or a stalled labour. In patients with severe pre-eclampsia, maternal complications such as PPH, eclampsia, acute renal failure, HELLP syndrome, pulmonary edoema, and maternal fatalities were observed in 1.66% of cases. In our study, patients with severe pre-eclampsia experienced low birth weight in 80% of cases, foetal growth restriction in 20%, intrauterine foetal death in 5% of patients, and perinatal mortality in 12% of cases. Conclusion: Patients with severe pre-eclampsia and eclampsia are more likely to experience maternal and perinatal problems. Preventing severe pre-eclampsia and eclampsia requires good antenatal care, early diagnosis, and fast treatment.

 

 

 

Abstract (English)

Background: Pre-eclampsia is a major global contributor to maternal and neonatal morbidity and mortality. The majority of referrals to tertiary care centres are for pre-eclampsia. This study’s goal is to determine how patients with severe pre-eclampsia will fare maternally and perinatally. Methods: The Department of Obstetrics and Gynecology at SKMCH, Muzaffarpur, Bihar, conducted this prospective study from January 2022 to December 2022. There were 240 women in total who had developed severe pre-eclampsia after 34 weeks of pregnancy. Women with a history of many pregnancies, anaemia, pre-existing hypertension, epilepsy, diabetes, or vascular or renal causes were not allowed to participate. After a thorough history, examination, and investigation, patients were handled in accordance with the established protocol. The preferred medication for treating convulsions was magnesium sulphate, while labetalol or oral nefidipine was used to regulate blood pressure. Results: Out of 240 occurrences of severe pre-eclampsia, most (70%) included women in their 20s and 30s who were also mostly primigravida (79.16%). The most frequent presenting symptom in the current study was edoema (80.8%), which was followed by headache (40.8%). 56.6% of women with severe pre-eclampsia gave birth naturally while 43.5% underwent caesarean sections, most often as a result of a botched induction or a stalled labour. In patients with severe pre-eclampsia, maternal complications such as PPH, eclampsia, acute renal failure, HELLP syndrome, pulmonary edoema, and maternal fatalities were observed in 1.66% of cases. In our study, patients with severe pre-eclampsia experienced low birth weight in 80% of cases, foetal growth restriction in 20%, intrauterine foetal death in 5% of patients, and perinatal mortality in 12% of cases. Conclusion: Patients with severe pre-eclampsia and eclampsia are more likely to experience maternal and perinatal problems. Preventing severe pre-eclampsia and eclampsia requires good antenatal care, early diagnosis, and fast treatment.

 

 

 

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Dates

Accepted
2023-02-06

References

  • 1. Roberts JM, Pearson G, Cutler I, Lindheimer M. Summary of the NHLBI working group on research on hypertension during pregnancy. Hypertension, 2003; 41: 437-45. 2. Khedum SM, Moodley J, Naicker T, Maharaj B. Drug Management of hypertensive disorders of pregnancy. Pharmacol Ther., 1997; 74(2): 221-58. 3. Ngoc NT, Merialdi M, Abdel- Aleem H, Carroli G, Purwar M, Zavaleta N, et al. Causes of still births and early neonatal deaths: data from 7993 pregnancies in six developing countries. Bull world Health organ, 2006; 84(9): 699-705. 4. Report of the national high blood pressure education program: working group on high blood pressure in pregnancy. Am J Obstet Gynaecol., 2000; 183: 51-22. 5. Douglas KA, Redman CW. Eclampsia in the United Kingdom. BMJ, 1994; 309: 1395-400. 6. Bedi N, Kamby I, Dhillon B.S, Saxena BN, Singh P. Maternal deaths in Indiapreventable tragedies. J Obstet Gynaecol Ind., 2001; 51: 86-92. 7. Abraham KA, Conolly G, Farrel J, Walshe JJ. The HELLP syndrome a prospective study. Ren Fail, 2001; 23: 705-13. 8. Weinstein L. Syndrome of hemolysis, elevated liver enzymes and low platelet count: a severe consequence of hypertension in pregnancy. Am J Obstet and Gynaecol., 1982; 142: 195-67. 9. Saxena N, et al. Maternal and perinatal outcome in severe preeclampsia and eclampsia. Int J Reprod Contracept Obstet Gynecol., 2016 Jul; 5(7): 2171- 2176. 10. Alvarez Navaswes R, Marin R. Severe maternal complications associated withpre-eclampsia: an almost forgotten pathology. Nefrologia, 2001; 21(6): 565- 73. 11. Churchchill D, Perry IJ, Beevers DG. Ambulatory blood pressure in pregnancy and fetal growth. Lancet, 1997; 349: 7- 10. 12. Robert JM. Endothelial dysfunction in preeclampsia. Semin Reprod Endocrinal., 1998; 16: 5-15. 13. Multi-disciplinary management of severe pre-eclampsia (PE) expert guidelines 2008, societte francaise de medicine perinatale society francaise se neonatologic. Ann Fr Anaesth Reanim., 2009; 28: 275-81. 14. Pottecher T, Luton D. Prise encharge multidisciplanry de la preeclampsia French, Issyles Moulineaux, France, Elsevir; Masson SAS; 2009. 15. Minire A, Mirton M, Imri V, Lauren M, Aferdita M. Maternal complications of pre-eclampsia. Med Arch., 2013; 67(5): 339-41. 16. Odendaal HJ, Pattinson RC, Bam R, Grore D., Kotze JVWT. Aggressive or expectant management for patients with severe pre-eclampsia between 28-34 weeks gestation a randomized controlled trial. Obstetrics and Gynecology, 1990; 76(6): 1070-5. 17. Duley L. Preeclampsia and the hypersensitive disorder of pregnancy. British Medical Bulletin, 2003; 67: 161- 76. 18. World health organization fact sheet 2012. 19. Lack of pre-eclampsia awareness increases risk of infant mortality press release, preeclampsia foundation, 2008. 20. Prichard, Weissman R, Ratnoff OD. Intravascular hemolysis, thrombocytophenia & other hematologic abnormalities associated with severe toxemia of pregnancy. N Engl J Med., 1954; 250: 89-98. 21. Sibai B, Kupfermic M. Pre-eclampsia. Lancet, 2005; 365: 785-99. 22. Sibai BM. Magnesium sulphate prophylaxis in pre-eclampsia. Lesson learned from recent trials. Am J obstet gynecol., 2004:190: 1520-6. 23. Naseer D, Ataullah K, Nudrat E. Perinatal and maternal outcome of eclamptic patients admitted in Nishtar hospital, Multan. J Coll Physician Surg Pak., 2000; 10: 261-4. 24. Singhal S, Deepika, Anusha, Nandha S. Maternal and perinatal outcome in severe preeclampsia and eclampsia. South Asian Federation of Obstetrics and Gynaecology, 2009; 1(3): 25-8. 25. Katz VL, Farmer R, Kuller Ja. Preeclampsia into eclampsia: toward a new paradigm. Am J Obstet gynecol., 2000; 182: 1389-96. 26. Rekha Sachin, Munna Lal Patel, Pushapalata Sachan. Outcome of hypersenstive disorder of pregnancy in the North Indian population. International Journal of Womens health, 2013; 5: 101- 108. 27. Tavassoli Fatemeth, Ghasemi Msrziyeh, Ghomian Nayereh. Maternal and Perinatal outcome in nulliparous women complicated with pregnancy hypertension. J Park Med Association, 2010; 09: 707-710.