A Case Control Assessment of the Diagnostic Tests and Conjunctival Impression Cytology in Individuals Diagnosed with Dry Eye Illness
Authors/Creators
- 1. Senior Resident, Department of RIO, IGIMS, Patna, Bihar, India
- 2. Senior Resident, Department of Ophthalmology, PMCH, Patna, Bihar, India
- 3. professor, Department of Ophthalmology, PMCH, Patna, Bihar, India
- 4. Professor, Department of ROI, IGIMS, Patna, Bihar, India
- 5. Associate professor, Department of Nephrology, NMCH, Patna, Bihar, India
Description
Abstract
Aim: Comparative analysis of diagnostic tests and conjunctival impression cytology in individuals diagnosed
with dry eye illness and a control group of healthy individuals.
Material and Methods: This study was conducted in the Department of RIO, IGIMS, Patna, Bihar, India for one
year. A total of 142 patients (74 cases and 68 controls) successfully completed the study. Informed consent was
obtained from all patients prior to enrolment in this study. For cases, patients from 20 years up to the age of 60
years, either sex who fulfilled the inclusion/exclusion criteria, were included. For controls, patients from 20 years
up to the age of 60 years who fulfilled the inclusion/exclusion criteria were included. All the subjects who were
included as cases or controls were asked to respond to OSDI questionnaire. Based on their OSDI scores, patients
were categorized as having a normal ocular surface (0-12 points) or as having mild (13-22 points), moderate (23-
32 points), and severe (33-100 points) ocular surface disease. The participants attaining the score 0-12 were
selected as controls while those with score 13-100 were taken as dry eye patients. The enrolled participants were
subjected to detailed medical history and clinical examination as per Performa.
Results: Conjunctival congestion was seen in 78.4% of cases and 58.8% of controls. Similarly, Normal
conjunctiva was seen in 16.2% of cases and 38.2% of controls. The difference was significant (p< 0.05). For
schirmer’s test, 8.8% eyes of cases and 6.6% eyes of controls had schirmer values of <5mm, similarly 12.8% of
cases and 7.4% of controls had values between 5 and 10mm. The values of >15mm were observed in 70.3% of
cases and 77.9% of controls. The difference was found not to be significant (p=0.379). For control group, the
mean was 24.32± 10.088, for case group, the mean was 23.34±11.662. For TBUT test, 18.9% eyes of cases and
13.2% eyes of controls had TBUT value of <5 sec, similarly 36.5% of cases and 24.3% of controls had values
between 5 and 10 sec.
Conclusion: TBUT and BME hold good diagnostic accuracy for dry eye evaluation in patients.
Abstract (English)
Abstract
Aim: Comparative analysis of diagnostic tests and conjunctival impression cytology in individuals diagnosed
with dry eye illness and a control group of healthy individuals.
Material and Methods: This study was conducted in the Department of RIO, IGIMS, Patna, Bihar, India for one
year. A total of 142 patients (74 cases and 68 controls) successfully completed the study. Informed consent was
obtained from all patients prior to enrolment in this study. For cases, patients from 20 years up to the age of 60
years, either sex who fulfilled the inclusion/exclusion criteria, were included. For controls, patients from 20 years
up to the age of 60 years who fulfilled the inclusion/exclusion criteria were included. All the subjects who were
included as cases or controls were asked to respond to OSDI questionnaire. Based on their OSDI scores, patients
were categorized as having a normal ocular surface (0-12 points) or as having mild (13-22 points), moderate (23-
32 points), and severe (33-100 points) ocular surface disease. The participants attaining the score 0-12 were
selected as controls while those with score 13-100 were taken as dry eye patients. The enrolled participants were
subjected to detailed medical history and clinical examination as per Performa.
Results: Conjunctival congestion was seen in 78.4% of cases and 58.8% of controls. Similarly, Normal
conjunctiva was seen in 16.2% of cases and 38.2% of controls. The difference was significant (p< 0.05). For
schirmer’s test, 8.8% eyes of cases and 6.6% eyes of controls had schirmer values of <5mm, similarly 12.8% of
cases and 7.4% of controls had values between 5 and 10mm. The values of >15mm were observed in 70.3% of
cases and 77.9% of controls. The difference was found not to be significant (p=0.379). For control group, the
mean was 24.32± 10.088, for case group, the mean was 23.34±11.662. For TBUT test, 18.9% eyes of cases and
13.2% eyes of controls had TBUT value of <5 sec, similarly 36.5% of cases and 24.3% of controls had values
between 5 and 10 sec.
Conclusion: TBUT and BME hold good diagnostic accuracy for dry eye evaluation in patients.
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IJCPR,Vol16,Issue4,Article134 (1).pdf
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Additional details
Dates
- Accepted
-
2024-04-25