Correlation between Serum Thyroid Stimulating Hormone, Free Thyroxine, and Urinary Albumin Excretion in Euthyroid Individuals with Type II Diabetes Mellitus
- 1. Senior Resident, Department of General Medicine, Nalanda Medical College & Hospital, Patna, Bihar, India
Description
Background: The role of thyroid hormones in renal hemodynamics and glomerular filtration, impacting nephropathy progression, in euthyroid individuals with type II diabetes mellitus (T2DM) is underexplored. The study aimed to investigate the relation between serum thyroid stimulating hormone (TSH), free thyroxine (FT4), and urinary albumin excretion in euthyroid individuals with T2DM. Methods: A cross-sectional study of 215 euthyroid T2DM patients categorized into four age groups collected data from electronic medical records on demographics, HbA1c, serum TSH, FT4 levels, and urinary ACR, with TSH and FT4 measured via immunoradiometric and radioimmunoassay; statistical analyses included Pearson correlation and multivariate regression to assess the relation between thyroid function and urinary albumin excretion. Results: 2.4 ± 1.2 μIU/mL was the mean TSH level and 1.1 ± 0.3 ng/dL was the mean FT4 level. 60.5% of subjects had normal albuminuria, 27.9% had moderately elevated albuminuria, and 11.6% had significantly elevated albuminuria. urine albumin excretion and TSH showed a strong positive association (r = 0.45, p < 0.001), while FT4 and urine albumin excretion showed a negative correlation (r = -0.38, p < 0.001). Higher TSH and lower FT4 levels were independently linked to increased urine albumin excretion, as demonstrated by multivariate regression analysis (β = 0.43, p < 0.001 for TSH; β = -0.35, p < 0.001 for FT4). Conclusion: Thyroid function, even within the euthyroid range, is significantly associated with urinary albumin excretion in T2DM patients. Higher TSH and lower FT4 levels correlate with increased albuminuria, suggesting a potential role for thyroid function monitoring in managing diabetic nephropathy. Recommendations: Routine thyroid function monitoring in T2DM patients is advised to identify nephropathy risk, with further research needed to understand these associations and explore therapeutic interventions.
Abstract (English)
Background: The role of thyroid hormones in renal hemodynamics and glomerular filtration, impacting nephropathy progression, in euthyroid individuals with type II diabetes mellitus (T2DM) is underexplored. The study aimed to investigate the relation between serum thyroid stimulating hormone (TSH), free thyroxine (FT4), and urinary albumin excretion in euthyroid individuals with T2DM. Methods: A cross-sectional study of 215 euthyroid T2DM patients categorized into four age groups collected data from electronic medical records on demographics, HbA1c, serum TSH, FT4 levels, and urinary ACR, with TSH and FT4 measured via immunoradiometric and radioimmunoassay; statistical analyses included Pearson correlation and multivariate regression to assess the relation between thyroid function and urinary albumin excretion. Results: 2.4 ± 1.2 μIU/mL was the mean TSH level and 1.1 ± 0.3 ng/dL was the mean FT4 level. 60.5% of subjects had normal albuminuria, 27.9% had moderately elevated albuminuria, and 11.6% had significantly elevated albuminuria. urine albumin excretion and TSH showed a strong positive association (r = 0.45, p < 0.001), while FT4 and urine albumin excretion showed a negative correlation (r = -0.38, p < 0.001). Higher TSH and lower FT4 levels were independently linked to increased urine albumin excretion, as demonstrated by multivariate regression analysis (β = 0.43, p < 0.001 for TSH; β = -0.35, p < 0.001 for FT4). Conclusion: Thyroid function, even within the euthyroid range, is significantly associated with urinary albumin excretion in T2DM patients. Higher TSH and lower FT4 levels correlate with increased albuminuria, suggesting a potential role for thyroid function monitoring in managing diabetic nephropathy. Recommendations: Routine thyroid function monitoring in T2DM patients is advised to identify nephropathy risk, with further research needed to understand these associations and explore therapeutic interventions.
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IJPCR,Vol16,Issue6,Article418.pdf
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Additional details
Dates
- Accepted
-
2024-05-25
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue6,Article418.pdf
- Development Status
- Active
References
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