Feto-Maternal Outcome Assessment in Pregnant women with Thyroid Disorders: An Observational Study
Authors/Creators
- 1. Senior Resident, Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Patna, Bihar, India
- 2. Professor, Department of Obstetrics and Gynaecology, NMCH Patna, Bihar, India
Description
Abstract
Aim: To evaluate the impact of thyroid disorders on the health of both fetus and the mother during pregnancy.
Material and Methods: This observational study was conducted in the Department of Obstetrics and
Gynaecology, NMCH Patna, Bihar, India for one year. We recruited 294 antenatal women in third trimester
admitted into the obstetric ward with singleton pregnancy for other obstetric indications. Informed consent was
obtained from all subjects. Subjects were chosen irrespective of age, parity, residence and socioeconomic status.
Women with multiple pregnancies, a known case of thyroid disorder, on any treatment or with any pre-existing
medical disorder, such as diabetes mellitus, or cardiac or pulmonary disease were excluded. Routine
hematological parameters and estimation of T3, T4 and TSH was conducted. Patients with a deranged thyroid
profile were subsequently assessed for maternal and fetal complications. Infertility, family history of thyroid
disorder, menstrual history, recurrent abortions, mean T3, T4, TSH levels, haemoglobin levels, maternal and fetal
outcome were the main study variables.
Results: Of the 294 women screened, 46 (15.64%) had abnormal thyroid function. Prevalence of subclinical
hypothyroidism, overt hypothyroidism, and subclinical hyperthyroidism was 7.48% (n = 22), 5.10% (n = 15), and
3.06% (n = 9), respectively demonstrating that the occurrence of subclinical hypothyroidism is more common
during pregnancy. Of the 46 women with dysfunction, 23.91% had a history of irregular menstrual rhythm; 4.34%
had history of infertility treatment; 4.34% had family history of thyroid disorder and 4.34% had history of
recurrent miscarriage. There was no statistically significant association between any of these factors and the
occurrence of thyroid disorder (p values were 0.655, 0.217, 0.079, and 0.752, respectively).
Conclusion: Association of maternal anemia, preeclampsia, increased cesarean delivery, presence of LBW
babies, low Apgar score and increased number of NICU admission; is a major finding of this study
Abstract (English)
Abstract
Aim: To evaluate the impact of thyroid disorders on the health of both fetus and the mother during pregnancy.
Material and Methods: This observational study was conducted in the Department of Obstetrics and
Gynaecology, NMCH Patna, Bihar, India for one year. We recruited 294 antenatal women in third trimester
admitted into the obstetric ward with singleton pregnancy for other obstetric indications. Informed consent was
obtained from all subjects. Subjects were chosen irrespective of age, parity, residence and socioeconomic status.
Women with multiple pregnancies, a known case of thyroid disorder, on any treatment or with any pre-existing
medical disorder, such as diabetes mellitus, or cardiac or pulmonary disease were excluded. Routine
hematological parameters and estimation of T3, T4 and TSH was conducted. Patients with a deranged thyroid
profile were subsequently assessed for maternal and fetal complications. Infertility, family history of thyroid
disorder, menstrual history, recurrent abortions, mean T3, T4, TSH levels, haemoglobin levels, maternal and fetal
outcome were the main study variables.
Results: Of the 294 women screened, 46 (15.64%) had abnormal thyroid function. Prevalence of subclinical
hypothyroidism, overt hypothyroidism, and subclinical hyperthyroidism was 7.48% (n = 22), 5.10% (n = 15), and
3.06% (n = 9), respectively demonstrating that the occurrence of subclinical hypothyroidism is more common
during pregnancy. Of the 46 women with dysfunction, 23.91% had a history of irregular menstrual rhythm; 4.34%
had history of infertility treatment; 4.34% had family history of thyroid disorder and 4.34% had history of
recurrent miscarriage. There was no statistically significant association between any of these factors and the
occurrence of thyroid disorder (p values were 0.655, 0.217, 0.079, and 0.752, respectively).
Conclusion: Association of maternal anemia, preeclampsia, increased cesarean delivery, presence of LBW
babies, low Apgar score and increased number of NICU admission; is a major finding of this study
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Additional details
Dates
- Accepted
-
2024-04-23