An Evaluation of Chest Computed Tomographic Features in Multi - Drug Resistant Tuberculosis
Authors/Creators
- 1. Assistant Professor, Department of Radio – Diagnosis, Government Sivagangai Medical College and Hospital, Sivagangai
- 2. Assistant Professor, Department of Radio – Diagnosis, Government Ramanathapuram Medical College and Hospital, Ramanathapuram
- 3. Assistant Professor, Department of Radio – Diagnosis, Government Thanjavur Medical College and Hospital, Thanjavur
- 4. Assistant Professor, Department of Radio – Diagnosis, Government Coimbatore Medical College and Hospital, Coimbatore
Description
Introduction: Diagnosis of drug sensitive Tuberculosis and Multi drug resistant tuberculosis (MDR – TB) starts with identifying acid fast bacilli (AFB) from sputum but to confirm the diagnosis sputum culture is mandatory which often takes at least two to three weeks. Similar failure to first line anti-TB treatment in MDR-TB and drug sensitive TB lead to misdiagnosis and deferred treatment with rise in pathogen spread. So we are in need an alternative way of early diagnosis and treatment. Objectives: 1. To evaluate the chest tomographic features of multi-drug resistant tuberculosis (MDR-TB) patients 2. To detect the characteristic radiological features of MDR-TB, which would prove as findings to detect the doubt of MDR-TB in a patient with tuberculosis. So, they referred to gene expert for early detection and further management. Materials and Methods: Total of 405 patient’s underwent CT-chest during the study period and 100 cases proved MDR – TB in the study. Age, Gender, history of anti-tuberculosis drug taken and CT chest features were analyzing for the MDR – TB patients. Results: Multiple thick-walled cavity and consolidation with cavitation were more commonly seen in MDR-TB patients. When these findings were present, they were extensive and involved all lobes. Pleural effusion, fibrosis, atelectasis, bronchiectasis and mediastinal lymphadenopathy is more commonly seen in multi drug resistant tuberculosis patients. Conclusion: The feature of multiple thick-walled cavities, consolidation with cavitation with extensively noted in multiple lobes of bilateral lung fields should raise the doubt of multi-drug resistance Tuberculosis. These patients should be refers to gene-expert to confirm the diagnosis and further treatment / Management.
Abstract (English)
Introduction: Diagnosis of drug sensitive Tuberculosis and Multi drug resistant tuberculosis (MDR – TB) starts with identifying acid fast bacilli (AFB) from sputum but to confirm the diagnosis sputum culture is mandatory which often takes at least two to three weeks. Similar failure to first line anti-TB treatment in MDR-TB and drug sensitive TB lead to misdiagnosis and deferred treatment with rise in pathogen spread. So we are in need an alternative way of early diagnosis and treatment. Objectives: 1. To evaluate the chest tomographic features of multi-drug resistant tuberculosis (MDR-TB) patients 2. To detect the characteristic radiological features of MDR-TB, which would prove as findings to detect the doubt of MDR-TB in a patient with tuberculosis. So, they referred to gene expert for early detection and further management. Materials and Methods: Total of 405 patient’s underwent CT-chest during the study period and 100 cases proved MDR – TB in the study. Age, Gender, history of anti-tuberculosis drug taken and CT chest features were analyzing for the MDR – TB patients. Results: Multiple thick-walled cavity and consolidation with cavitation were more commonly seen in MDR-TB patients. When these findings were present, they were extensive and involved all lobes. Pleural effusion, fibrosis, atelectasis, bronchiectasis and mediastinal lymphadenopathy is more commonly seen in multi drug resistant tuberculosis patients. Conclusion: The feature of multiple thick-walled cavities, consolidation with cavitation with extensively noted in multiple lobes of bilateral lung fields should raise the doubt of multi-drug resistance Tuberculosis. These patients should be refers to gene-expert to confirm the diagnosis and further treatment / Management.
Files
IJPCR,Vol15,Issue2,Article40.pdf
Files
(4.3 MB)
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Additional details
Dates
- Accepted
-
2023-02-03
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue2,Article40.pdf
- Development Status
- Active
References
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