An Observational Assessment of Bone Minerals, Calcium and Phosphorus in Hypothyroidism and its Relation with Thyroid Hormone Levels
Creators
- 1. Associate Professor, Department of Biochemistry, Department of Biochemistry, Narayan Medical College & Hospital, Jamuhar, Sasaram, Bihar, India
- 2. Professor & Head, Department of Biochemistry, Department of Biochemistry, Narayan Medical College & Hospital, Jamuhar, Sasaram, Bihar, India
Description
Abstract
Aim: The aim of the present study was to assess the levels of bone minerals, calcium and phosphorus in
hypothyroidism and its relation with thyroid hormone levels.
Methods: The cross-sectional and observational study was done at department of Biochemistry, NMCH, Jamuhar,
Sasaram, Bihar over a period of 12 months (August 2022 to July 2023)
Results: There was a significant increase of TSH, in cases with p value < 0.001. Significant decrease in T4 was
noted (p <0.05) in cases. Among the minerals, there was a significant increase in phosphorous and magnesium
serum levels and a significant decrease in that of calcium levels. In our study analysis when TSH levels were
compared with serum calcium and phosphorus among the hypothyroid patients, it showed a statistically significant
negative correlation between TSH and serum calcium. However there was no significant correlation of TSH with
serum phosphorous and magnesium.
Conclusion: The study concluded that in hypothyroid patients, the serum calcium level was decreased and serum
phosphorus level was increased when compared to euthyroid control subjects. Also there was a strong negative
correlation between serum TSH and serum calcium levels were observed among hypothyroid individuals. It is
therefore recommended for the regular evaluation of these minerals in hypothyroid patients which would improve
their bone health and quality of life.
Abstract (English)
Abstract
Aim: The aim of the present study was to assess the levels of bone minerals, calcium and phosphorus in
hypothyroidism and its relation with thyroid hormone levels.
Methods: The cross-sectional and observational study was done at department of Biochemistry, NMCH, Jamuhar,
Sasaram, Bihar over a period of 12 months (August 2022 to July 2023)
Results: There was a significant increase of TSH, in cases with p value < 0.001. Significant decrease in T4 was
noted (p <0.05) in cases. Among the minerals, there was a significant increase in phosphorous and magnesium
serum levels and a significant decrease in that of calcium levels. In our study analysis when TSH levels were
compared with serum calcium and phosphorus among the hypothyroid patients, it showed a statistically significant
negative correlation between TSH and serum calcium. However there was no significant correlation of TSH with
serum phosphorous and magnesium.
Conclusion: The study concluded that in hypothyroid patients, the serum calcium level was decreased and serum
phosphorus level was increased when compared to euthyroid control subjects. Also there was a strong negative
correlation between serum TSH and serum calcium levels were observed among hypothyroid individuals. It is
therefore recommended for the regular evaluation of these minerals in hypothyroid patients which would improve
their bone health and quality of life.
Files
IJCPR,Vol16,Issue6,Article27.pdf
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Additional details
Dates
- Accepted
-
2024-06-10