Tranexamic acid to Reduce Blood Loss in Women at High Risk for Postpartum Hemorrhage undergoing Cesarean Section: A Randomized Controlled Trial
- 1. Senior Resident, Department of Obstetrics and Gynaecology, Sri Krishna Medical College and Hospital, Muzaffarpur, Bihar
- 2. Professor and Head of Department, Department of Obstetrics and Gynaecology, Sri Krishna Medical College and Hospital, Muzaffarpur, Bihar
Description
Background: One of the leading causes of maternal death worldwide is postpartum haemorrhage. Significant blood loss raises the risks associated with blood transfusions and, as a result, raises the possibility of needing urgent surgical operations like artery ligation or hysterectomy. In low- or middle-income nations in particular, it can also result in prolonged anaemia. This study goal was to find out whether tranexamic acid effectively and safely reduces blood loss during and after lower segment caesarean sections. Method: From January 2022 to December 2022, 200 women who were having lower segment caesarean sections (LSCS) at the Obstetrics and Gynecology Department at SKMCH, Muzaffarpur, Bihar, participated in a randomised, controlled trial. One gramme of tranexamic acid was administered intravenously to 100 of them 20 minutes prior to making a skin cut so that they could be compared to 100 additional individuals who did not receive it. During two sessions, blood loss was measured and collected. The first period covered the time from placental delivery to the end of LSCS, while the second covered 2 hours after delivery. Results: Tranexamic acid significantly decreased blood loss from the conclusion of LSCS to two hours after delivery; it went from 128.57±23.72 ml in the control group to 79.0±14.18 ml in the experimental group (p=0.0001). The amount of blood loss from placental delivery to end of LSCS was also considerably less in the study group than in the control group (308.80±43.60 ml versus 349.18±42.17 ml) (P=0.0001). In neither group were there any complications or negative effects noted. Conclusion: The use of tranexamic acid significantly reduces the amount of blood loss during and after the lower segment caesarean section and has no adverse side effects or problems, such as thrombosis. Tranexamic acid can be used effectively and safely in women having LSCS.
Abstract (English)
Background: One of the leading causes of maternal death worldwide is postpartum haemorrhage. Significant blood loss raises the risks associated with blood transfusions and, as a result, raises the possibility of needing urgent surgical operations like artery ligation or hysterectomy. In low- or middle-income nations in particular, it can also result in prolonged anaemia. This study goal was to find out whether tranexamic acid effectively and safely reduces blood loss during and after lower segment caesarean sections. Method: From January 2022 to December 2022, 200 women who were having lower segment caesarean sections (LSCS) at the Obstetrics and Gynecology Department at SKMCH, Muzaffarpur, Bihar, participated in a randomised, controlled trial. One gramme of tranexamic acid was administered intravenously to 100 of them 20 minutes prior to making a skin cut so that they could be compared to 100 additional individuals who did not receive it. During two sessions, blood loss was measured and collected. The first period covered the time from placental delivery to the end of LSCS, while the second covered 2 hours after delivery. Results: Tranexamic acid significantly decreased blood loss from the conclusion of LSCS to two hours after delivery; it went from 128.57±23.72 ml in the control group to 79.0±14.18 ml in the experimental group (p=0.0001). The amount of blood loss from placental delivery to end of LSCS was also considerably less in the study group than in the control group (308.80±43.60 ml versus 349.18±42.17 ml) (P=0.0001). In neither group were there any complications or negative effects noted. Conclusion: The use of tranexamic acid significantly reduces the amount of blood loss during and after the lower segment caesarean section and has no adverse side effects or problems, such as thrombosis. Tranexamic acid can be used effectively and safely in women having LSCS.
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IJPCR,Vol15,Issue3,Article198.pdf
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Additional details
Dates
- Accepted
-
2023-03-26
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue3,Article198.pdf
- Development Status
- Active
References
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