Assessment of the Association between Severity of Liver Cirrhosis and Thyroid Profile in Patients with Reported with Thyroid Dysfunction
Authors/Creators
- 1. Associate Professor, Department of Medicine, Jawaharlal Nehru Medical College and Hospital, Bhagalpur, Bihar, India
- 2. JR-3, Department of Medicine, Jawaharlal Nehru Medical College and Hospital, Bhagalpur, Bihar, India
Description
Aim: This study was conducted to study thyroid dysfunction in patients of liver cirrhosis and any association between severity of liver cirrhosis and thyroid profile. Methods: This case-control study was conducted in the Department of Medicine, Jawaharlal Nehru Medical College and Hospital, Bhagalpur, Bihar, India. A total of 100 liver cirrhosis patients (case) and equal number (100) of healthy controls were included in this study. The study was conducted for the period of one year. Results: A total of 100 liver cirrhosis cases (70 males and 30 females) and 100 apparently healthy controls (65 males and 35 females) were included in the final analysis. The mean age was 49.22 ± 7.22 years for cases and 49.14 ± 6.27 years for controls. Controls as compared to cases had higher free T3 (fT3) (2.45 ± 0.40 vs. 1.60 ± 0.50 pg/ml) and free T4 (fT4) (1.26 ± 0.21 vs. 1.15 ± 0.48 ng/ml), although the difference was significant only for free T3. On the contrary, TSH values of cases were found to be significantly higher as compared to that of controls (3.61 ± 0.95 vs. 3.01 ± 0.66 μIU/ml). Low T3 syndrome and hypothyroidism were common thyroid disorders (23% and 18%), normal thyroidal illness syndrome with low T4 and high T4 were observed among 16% and 12% cases, whereas out of 100 controls, 90 (90%) did not have any abnormality in thyroid functions. Only 8 (8%) cases were diagnosed as normal thyroidal illness syndrome with high T4 abnormality. The association of severity of liver disease was found to be significant only for fT3 levels while a significant increment in proportion of cases with thyroid dysfunction was observed with increase in severity of the disease, i.e., Category A (20%), Category B (70%), and Category C (90.0%). Conclusion: Liver disease cases as compared to controls had significantly lower fT3 levels and significantly higher TSH levels. Mortality rate of liver disease cases with thyroid dysfunction was also found to be significantly higher.
Abstract (English)
Aim: This study was conducted to study thyroid dysfunction in patients of liver cirrhosis and any association between severity of liver cirrhosis and thyroid profile. Methods: This case-control study was conducted in the Department of Medicine, Jawaharlal Nehru Medical College and Hospital, Bhagalpur, Bihar, India. A total of 100 liver cirrhosis patients (case) and equal number (100) of healthy controls were included in this study. The study was conducted for the period of one year. Results: A total of 100 liver cirrhosis cases (70 males and 30 females) and 100 apparently healthy controls (65 males and 35 females) were included in the final analysis. The mean age was 49.22 ± 7.22 years for cases and 49.14 ± 6.27 years for controls. Controls as compared to cases had higher free T3 (fT3) (2.45 ± 0.40 vs. 1.60 ± 0.50 pg/ml) and free T4 (fT4) (1.26 ± 0.21 vs. 1.15 ± 0.48 ng/ml), although the difference was significant only for free T3. On the contrary, TSH values of cases were found to be significantly higher as compared to that of controls (3.61 ± 0.95 vs. 3.01 ± 0.66 μIU/ml). Low T3 syndrome and hypothyroidism were common thyroid disorders (23% and 18%), normal thyroidal illness syndrome with low T4 and high T4 were observed among 16% and 12% cases, whereas out of 100 controls, 90 (90%) did not have any abnormality in thyroid functions. Only 8 (8%) cases were diagnosed as normal thyroidal illness syndrome with high T4 abnormality. The association of severity of liver disease was found to be significant only for fT3 levels while a significant increment in proportion of cases with thyroid dysfunction was observed with increase in severity of the disease, i.e., Category A (20%), Category B (70%), and Category C (90.0%). Conclusion: Liver disease cases as compared to controls had significantly lower fT3 levels and significantly higher TSH levels. Mortality rate of liver disease cases with thyroid dysfunction was also found to be significantly higher.
Files
IJPCR,Vol15,Issue3,Article117.pdf
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Additional details
Dates
- Accepted
-
2023-03-05
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue3,Article117.pdf
- Development Status
- Active
References
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