A Randomised Clinical Assessment of Inj. Rocuronium with Priming Dose and Inj. Rocuronium without Priming in Patients Undergoing General Anaesthesia
Authors/Creators
- 1. Senior Resident, Department of Anesthesia, Sri Krishna Medical College & Hospital, Muzaffarpur, Bihar, India
- 2. Associate professor, Department of Anesthesia, Sri Krishna Medical College & Hospital, Muzaffarpur, Bihar, India
- 3. Assistant professor and HOD, Department of Anesthesia, Sri Krishna Medical College & Hospital, Muzaffarpur, Bihar, India
Description
Aim: The aim of the present study was to compare the effect of inj. Rocuronium with priming dose and inj.
Rocuronium without priming on intubating conditions and onset time of intubation with respect to rocuronium as
bolus.
Methods: The present study was single-center, retrospective study, conducted in Department of Anesthesia, Sri
Krishna Medical College & Hospital, Muzaffarpur, Bihar, India. Study duration was of one year. 100 patients
were included in the study.
Results: We compared mean age, weight, gender and ASA grade between group C and group P and difference
was statistically not significant (p value >0.05). We compared preoperatively baseline mean HR, mean HR at
induction, mean HR at intubation, at 1 minute after intubation and at 5 minute after intubation between group C
and group P, the difference between two groups was statistically insignificant. We compared mean MAP
preoperatively baseline, at induction, at intubation, mean HR at 1 minute after intubation and mean HR at 5
minutes after intubation between group C and group P, the difference between two groups was statistically
insignificant. We compared mean SPO2 preoperatively baseline, at induction, at intubation, mean HR at 1 minute
after intubation and mean HR at 5 minutes after intubation between group C and group P, the difference between
two groups was statistically insignificant. In group C mean Onset Time of Intubation was 93.36 ± 6.24 seconds,
while in group P it was 57.00 ± 6.74 seconds, so the difference between the groups on the basis of OTI was
statistically highly significant.
Conclusion: Rocuronium with priming would be an excellent alternative to succinylcholine, whenever fast
induction will be needed. Intubating conditions were good to excellent and comparable in both rocuronium with
priming and without priming. NMT monitoring is a useful tool for indicating the clinically acceptable paralysis.
Abstract (English)
Aim: The aim of the present study was to compare the effect of inj. Rocuronium with priming dose and inj.
Rocuronium without priming on intubating conditions and onset time of intubation with respect to rocuronium as
bolus.
Methods: The present study was single-center, retrospective study, conducted in Department of Anesthesia, Sri
Krishna Medical College & Hospital, Muzaffarpur, Bihar, India. Study duration was of one year. 100 patients
were included in the study.
Results: We compared mean age, weight, gender and ASA grade between group C and group P and difference
was statistically not significant (p value >0.05). We compared preoperatively baseline mean HR, mean HR at
induction, mean HR at intubation, at 1 minute after intubation and at 5 minute after intubation between group C
and group P, the difference between two groups was statistically insignificant. We compared mean MAP
preoperatively baseline, at induction, at intubation, mean HR at 1 minute after intubation and mean HR at 5
minutes after intubation between group C and group P, the difference between two groups was statistically
insignificant. We compared mean SPO2 preoperatively baseline, at induction, at intubation, mean HR at 1 minute
after intubation and mean HR at 5 minutes after intubation between group C and group P, the difference between
two groups was statistically insignificant. In group C mean Onset Time of Intubation was 93.36 ± 6.24 seconds,
while in group P it was 57.00 ± 6.74 seconds, so the difference between the groups on the basis of OTI was
statistically highly significant.
Conclusion: Rocuronium with priming would be an excellent alternative to succinylcholine, whenever fast
induction will be needed. Intubating conditions were good to excellent and comparable in both rocuronium with
priming and without priming. NMT monitoring is a useful tool for indicating the clinically acceptable paralysis.
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Additional details
Dates
- Accepted
-
2024-03-25