A Retrospective Study of Clinical Profile and Risk Factors of Pulmonary Arterial Hypertension in Chronic Kidney Disease

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Abstract (English)

Aim: The aim of the present study was to assess the occurrence of pulmonary arterial hypertension in chronic
kidney disease and to study the risk factors for development of pulmonary arterial in these patients.
Methods: This was an observational cross section study conducted on 100 patients of CKD (based on KDIGO
2012 criteria) attending medicine OPD or admitted to Department of General Medicine, Jannayak Karpoori
Thakur Medical College and Hospital Madhepura,, Bihar, India
Results: Pulmonary hypertension was found in 60 patients (60%) of the study population. No significant
association was seen between age, BMI, presence of diabetes and S. Uric acid with presence of PH. Significant
association was seen of systolic and diastolic blood pressure with PH. Significant association was also seen of
severity of CKD with PH. Presence of hemodialysis and dialysis duration were significantly associated with PH.
Of 60 patients with PH, 23 patients had mild PH, 32 patients had moderate PH and 5 patients had severe PH.
Conclusion: We concluded that pulmonary arterial hypertension is significantly associated in patients of CKD
and increase in severity of PAH occurs with deterioration of renal function in CKD cases. Anemia, duration of
dialysis, hypertension, hyperparathyroidism, AV fistula, increased calcium phosphate product and left ventricular
failure are risk factors for development of PAH.