A Study to Estimate Oxidative Stress and Antioxidant Status in Tropical Chronic Pancreatitis (TCP) and Alcoholic Chronic Pancreatitis (ACP) and Correlate with Zinc Status
Authors/Creators
- 1. (DrNB) Academic Senior Resident, Department of Gastroenterology, Big Apollo Spectra Hospital Patna, Bihar, India
- 2. Consultant, Gastroenterologist, Big Apollo Spectra Hospital Patna, Bihar, India
Description
Abstract
Aim: The aim of the present study was to estimate oxidative stress and antioxidant status in tropical chronic
pancreatitis (TCP) and alcoholic chronic pancreatitis (ACP) and correlate with zinc status.
Methods: The present study was conducted in the Department of Gastroenterology, Big Apollo Spectra Hospital
Patna, Bihar, India and Chronic pancreatitis patients were recruited for the study and was diagnosed on the basis
of presence of pancreatic calcification (US/CT) and/or parenchymal or ductal changes on imaging. 100 patients
were included in the study. This study was approved by the Institutional Ethics Committee and written informed
consent was obtained from the subjects before enrollment.
Results: Of the 100 patients, there were 50 TCP patients and 50 ACP patients. The mean age of all CP patients
was comparable with the age of controls; however, TCP patients were younger than ACP patients. The mean body
mass index was comparable in all three groups. The erythrocyte GSH, GPx, SOD, and plasma vitamin C levels
were lower, and erythrocyte TBARS was higher in both TCP and ACP patients as compared to healthy controls.
Plasma vitamin C was lower whereas, erythrocyte TBARS was higher in TCP patients as compared to ACP
patients. Erythrocyte GSH level was significantly low in ACP as compared to TCP patients. We found lower
values of erythrocyte GSH, GPx, SOD, and plasma vitamin C and higher erythrocyte TBARS in both diabetic and
non-diabetic CP patients as compared to healthy controls. However, we did not find differences between diabetic
and non-diabetic TCP patients or between diabetic and non-diabetic ACP patients.
Conclusion: The study corroborates the role of oxidative stress in CP and suggests some differences in oxidative
status in TCP and ACP patients. Zinc deficiency appears to affect oxidative status in CP patients
Abstract (English)
Abstract
Aim: The aim of the present study was to estimate oxidative stress and antioxidant status in tropical chronic
pancreatitis (TCP) and alcoholic chronic pancreatitis (ACP) and correlate with zinc status.
Methods: The present study was conducted in the Department of Gastroenterology, Big Apollo Spectra Hospital
Patna, Bihar, India and Chronic pancreatitis patients were recruited for the study and was diagnosed on the basis
of presence of pancreatic calcification (US/CT) and/or parenchymal or ductal changes on imaging. 100 patients
were included in the study. This study was approved by the Institutional Ethics Committee and written informed
consent was obtained from the subjects before enrollment.
Results: Of the 100 patients, there were 50 TCP patients and 50 ACP patients. The mean age of all CP patients
was comparable with the age of controls; however, TCP patients were younger than ACP patients. The mean body
mass index was comparable in all three groups. The erythrocyte GSH, GPx, SOD, and plasma vitamin C levels
were lower, and erythrocyte TBARS was higher in both TCP and ACP patients as compared to healthy controls.
Plasma vitamin C was lower whereas, erythrocyte TBARS was higher in TCP patients as compared to ACP
patients. Erythrocyte GSH level was significantly low in ACP as compared to TCP patients. We found lower
values of erythrocyte GSH, GPx, SOD, and plasma vitamin C and higher erythrocyte TBARS in both diabetic and
non-diabetic CP patients as compared to healthy controls. However, we did not find differences between diabetic
and non-diabetic TCP patients or between diabetic and non-diabetic ACP patients.
Conclusion: The study corroborates the role of oxidative stress in CP and suggests some differences in oxidative
status in TCP and ACP patients. Zinc deficiency appears to affect oxidative status in CP patients
Files
IJCPR,Vol16,Issue5,Article43.pdf
Files
(350.1 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:70da1940d205af3115c462d6fa666ffc
|
350.1 kB | Preview Download |
Additional details
Dates
- Accepted
-
2024-05-08