Hypertension is one of the most common communicable diseases nowadays and is the leading cause of death worldwide, affecting 1.4 billion people. Treatment options include the widely used calcium channel blockers, among which amlodipine, a dihydropyridine, has low renal clearance and long half-life and duration of action, which allows it to sustain its anti-hypertensive effect for more than 24 h following a single dose. It has proven to reduce BP variability and successfully lower BP. A simple, sensitive, specific, and validated UV method has been developed for the quantitative determination of Amlodipine besylate in pure and tablet dosage form. UV methods are simple, rapid, and cost-effective. They are suitable for routine quality control analysis in pharmaceutical formulations. UV spectroscopy avoids the need for complex separation techniques.

Key Words: Amlodipine, UV Spectroscopy, L type calcium channel blockers.