Published January 30, 2017
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Cytotoxic Potential of Humic Acid Synthesized Silver Nano Plates Against Dalton's Lymphoma Ascites
- 1. Department of Chemical Oceanography, Cochin University of Science and Technology, Cochin 682016, India.
- 2. Inter University Centre for Development of Marine Biotechnology, Cochin University of Science and Technology Cochin 682016, India.
Description
This is a first report on the cytotoxic activity of humic acid synthesized silver nanoplates (HAgNpl) against Dalton’s lymphoma ascites (DLA). Humic acid, a supramolecule, has been shown to possess various biological activities. Humic acid used in the present study for the synthesis of silver nanoplates is isolated from mangrove sediments. Chemical composition of the humic acid was analysed using solid state C-13 NMR spectroscopy. Morphology of nanoplates were investigated using SEM. Trypan blue viability assay was performed on Dalton’s Lymphoma Ascites (DLA cell lines) to evaluate the cytotoxic potential of the HAgNpl. Humic acid synthesized silver nanoplates proved to be effective against these malignant cells. The HAgNpl showed a dose dependent activity against DLA cells. This result highlights the potential role of HAgNpl in developing safe medicines against malignant lymphoma.
Abstract (English)
This is a first report on the cytotoxic activity of humic acid synthesized silver nanoplates (HAgNpl) against Dalton’s lymphoma ascites (DLA). Humic acid, a supramolecule, has been shown to possess various biological activities. Humic acid used in the present study for the synthesis of silver nanoplates is isolated from mangrove sediments. Chemical composition of the humic acid was analysed using solid state C-13 NMR spectroscopy. Morphology of nanoplates were investigated using SEM. Trypan blue viability assay was performed on Dalton’s Lymphoma Ascites (DLA cell lines) to evaluate the cytotoxic potential of the HAgNpl. Humic acid synthesized silver nanoplates proved to be effective against these malignant cells. The HAgNpl showed a dose dependent activity against DLA cells. This result highlights the potential role of HAgNpl in developing safe medicines against malignant lymphoma.
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2016-12-25
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References
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