Evaluating of Cardiac Alterations in Systemic Lupus Erythematous using at a Tertiary Care Centre
Authors/Creators
- 1. Senior Resident, Department of General Medicine, GMCH, Bettiah
- 2. Assistant Professor & Head, Department of General Medicine, GMCH, Bettiah
Description
Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory rheumatologic disease that can affect several organs such as skin, joints, and kidneys. One of the organs reported to be involved in SLE is the heart. It is a multiorgan autoimmune disease associated with high cardiovascular morbidity and mortality that primarily affects young women. Cardiac diseases in lupus may involve the endocardium, myocardium, and pericardium and may be responsible for fatal outcome. Some cardiovascular abnormalities are seen with positive anti Ro/SS-A, anti La/SS-B, anticardiolipin (aCL), and anti-double- stranded DNA (antids DNA). Moreover, endothelial dysfunction was reported in early SLE cases without CVDs which was mostly not related to a CL antibody, disease activity, or disease duration but rather related to renal disease, diastolic hypertension, and diabetes in SLE. The aim of this study is to assess the cardiac function in systemic lupus erythematosus by 2D echocardiography. Material and Method: This was a cross-sectional, observational type of study done in one year duration, Study was done in General medicine OPD, Rheumatology OPD and ward of Department of Medicine, GMCH, Bettiah. Conclusion: SLE patients had an increased prevalence of subclinical systolic and diastolic LV and RV dysfunction. This result advocates for regular follow-up and early screening of SLE patients. Accordingly, treatment focused on improving diastolic heart function may have a role in enhancing QoL and improving the prognosis of SLE patients.
Abstract (English)
Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory rheumatologic disease that can affect several organs such as skin, joints, and kidneys. One of the organs reported to be involved in SLE is the heart. It is a multiorgan autoimmune disease associated with high cardiovascular morbidity and mortality that primarily affects young women. Cardiac diseases in lupus may involve the endocardium, myocardium, and pericardium and may be responsible for fatal outcome. Some cardiovascular abnormalities are seen with positive anti Ro/SS-A, anti La/SS-B, anticardiolipin (aCL), and anti-double- stranded DNA (antids DNA). Moreover, endothelial dysfunction was reported in early SLE cases without CVDs which was mostly not related to a CL antibody, disease activity, or disease duration but rather related to renal disease, diastolic hypertension, and diabetes in SLE. The aim of this study is to assess the cardiac function in systemic lupus erythematosus by 2D echocardiography. Material and Method: This was a cross-sectional, observational type of study done in one year duration, Study was done in General medicine OPD, Rheumatology OPD and ward of Department of Medicine, GMCH, Bettiah. Conclusion: SLE patients had an increased prevalence of subclinical systolic and diastolic LV and RV dysfunction. This result advocates for regular follow-up and early screening of SLE patients. Accordingly, treatment focused on improving diastolic heart function may have a role in enhancing QoL and improving the prognosis of SLE patients.
Files
IJPCR,Vol16,Issue5,Article266.pdf
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Additional details
Dates
- Accepted
-
2024-03-23
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue5,Article266.pdf
- Development Status
- Active
References
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