Study of Correlation of Vitamin B12 with Thyroid Hormones in Anemic Pregnant Women
Creators
- 1. Tutor, Department of Biochemistry, GMCH, Purnea
- 2. Assistant Professor & Head, Department of Biochemistry, GMCH, Purnea
Description
Background and Objectives: Thyroid hormones are required for normal development as well as regulating metabolism in the adult. A decreased thyroid hormone adversely affects erythropoietic system causes anemia. Our objective was to assess the relationship between serum vitamin B12 levels and thyroid function in anemic pregnant women. The Aim and objective of the study was to compare the vitamin B12 with thyroid hormones in anemic pregnant women. Materials & Methods: Study consisted of 50 subjects from OPD/ GMCH, Purnea. The study groups were divided into Group I-25 anemic pregnant women and Group II-25 Non – anemic pregnant women. The serum samples were collected from each subject and levels of different biochemical parameters were estimated. Result: were noted. On comparing values in vitamin B 12 and thyroid hormones , among two groups, a significant difference (p<0.005) was found between few of them. Conclusion: Screening of vitamin B12 levels in first trimester itself will be beneficial to prevent the complications of pregnancy. Further, hypothyroidism also present. So, early diagnosis of these deficiencies will be useful to start giving supplements to avoid unwanted effects in pregnancy.
Abstract (English)
Background and Objectives: Thyroid hormones are required for normal development as well as regulating metabolism in the adult. A decreased thyroid hormone adversely affects erythropoietic system causes anemia. Our objective was to assess the relationship between serum vitamin B12 levels and thyroid function in anemic pregnant women. The Aim and objective of the study was to compare the vitamin B12 with thyroid hormones in anemic pregnant women. Materials & Methods: Study consisted of 50 subjects from OPD/ GMCH, Purnea. The study groups were divided into Group I-25 anemic pregnant women and Group II-25 Non – anemic pregnant women. The serum samples were collected from each subject and levels of different biochemical parameters were estimated. Result: were noted. On comparing values in vitamin B 12 and thyroid hormones , among two groups, a significant difference (p<0.005) was found between few of them. Conclusion: Screening of vitamin B12 levels in first trimester itself will be beneficial to prevent the complications of pregnancy. Further, hypothyroidism also present. So, early diagnosis of these deficiencies will be useful to start giving supplements to avoid unwanted effects in pregnancy.
Files
IJPCR,Vol16,Issue5,Article260.pdf
Files
(377.3 kB)
Name | Size | Download all |
---|---|---|
md5:8effbb114dc1949af691c551e87ce64a
|
377.3 kB | Preview Download |
Additional details
Dates
- Accepted
-
2024-03-08
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue5,Article260.pdf
- Development Status
- Active
References
- 1. Guerrero A, Pamplona R, Postero-Otin M, López- Torres M. Effect of thyroid status on lipid composition and peroxidation in the mouse liver.Free Rad Biol Med. 1999; 26(1-2): 73-80. 2. Lingidi JL, Mohapatra E, Zephy D, Kumari S. Serum Lipids and Oxidative Stress in Hyporthyrodism.Journal of Advance Research in Biological Sciences 2013;5 (1):63 -66. 3. Antonijević N., Nesović M., Trbojević B., Milosević R. Med. Pregl., 1999; 52(3-5),136 - 140. 4. Christ-Crain M., Meier C., Huber P., Zulewski H., StaubJ.J., Müller B. Hormones, 2003; 2: 237-242. 5. Mclean E, Benoist B, Allen LH. Review of the magnitude of folate and vitamin B12 deficiencies worldwide. Food Nutr Bull. 2008; 29 (2):38-51. 6. De Groot L, Abalovich M, Alexander EK, Amino N,Barbour L, et al. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2012; 97:2543–2565. 7. Spremovic-Radjenovic S, Gudovic A, Lazovic G, Marinkovic J, Radunovic N, et al. Fetal free thyroxine concentrations in pregnant women with autoimmune thyroid disease. J Clin Endocrinol Metab. 2012; 97: 4014–40 21. 8. Sande HV, Jacquemyn Y, Karepouan N, Ajaji M. Vitamin B12 in pregnancy: maternal andfetal/neonatal effects—a review. Open J Obstet Gynecol. 2013; 03:599. 9. Allen LH. How common is vitamin B-12 deficiency?Am J Clin Nutr. 2009; 89:693S–6 96S. 10. Bashetti S, Suhasini D, Krishnakumari M, Kundoor N, Vijayaraghavan R, Varma BA. Association of vitamin B12 and folic acid with thyroid hormones in pregnant women with hypothyroidism. Res J Pharm Biol Chem Sci. 2016; 7:2478–2484. 11. Snow CF. Laboratory diagnosis of vitamin B12 deficiency. Arch Inter Medicine. 1999; 159; 1289-98.12. Green R, Kinsella LJ. Current concepts in diagnosis of cobalamin deficiency. Neurol. 1995; 45:435-40. 13. Sande HV, Jacquemyn Y, Karepouan N, Ajaji M. Vitamin B12 in pregnancy: Maternal and fetal/neonatal effects—A review. Open J Obstet Gynecol. 2013;03(07):599. 14. Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, et al. Guidelines of the AmericanThyroid Association for the Diagnosis and and Postpartum. Thyroid. 2011; 21(10):1081–125. 15. Glinver D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. 1997;18: 404-433. 16. Saltar N, Greer IA, Louden J, Lindsay G, Mc Connell M, et al. Lipoprotein subfraction change in normal pregnancy threshold effect of plasma triglycerides on appearance of small dense low density lipoprotein. J Clin Endocrinol Metab. 1997; 82:2483-2491.