Investigation into the Outcomes of using Sublingual Misoprostol for Terminating Early Pregnancy
- 1. Senior Resident, Department of Obs & Gynae, NMCH, Patna
- 2. Professor & HOD, Department of Obs & Gynae, NMCH, Patna
Description
Background and Objectives: Medical methods emerged as an alternative to surgical abortion with the discovery of prostaglandins in the early1930. Nearly 20% of all confirmed pregnancies end in spontaneous abortion. Misoprostol’s use in early pregnancy for termination of Pregnancy its success. And failure is varied the dose and route are not well established. Studies evaluating different regimens, including combination mifepristone and misoprostol and alone regimens, show varying results related to safety, efficacy and other outcome. To study the efficacy of sublingual misoprostol in causing expulsion of products of conception in early pregnancy failure. Material and Methods: Women with an ultrasound diagnosis of early pregnancy failure, less than 12 weeks gestation were included in the study. Tablet Misoprostol 600 mcg was given six hourly sublingually for 3 doses. All observations were noted and analyzed. This study was carried out NMCH Patna. Study duration One year. Conclusion: The regime had 92.85% efficacy, acceptability (90%) and few side effects. Systemic review we find that medical methods of abortion utilizing combination mifepristone and misoprostol or misoprostol alone are effective, safe and acceptable.
Abstract (English)
Background and Objectives: Medical methods emerged as an alternative to surgical abortion with the discovery of prostaglandins in the early1930. Nearly 20% of all confirmed pregnancies end in spontaneous abortion. Misoprostol’s use in early pregnancy for termination of Pregnancy its success. And failure is varied the dose and route are not well established. Studies evaluating different regimens, including combination mifepristone and misoprostol and alone regimens, show varying results related to safety, efficacy and other outcome. To study the efficacy of sublingual misoprostol in causing expulsion of products of conception in early pregnancy failure. Material and Methods: Women with an ultrasound diagnosis of early pregnancy failure, less than 12 weeks gestation were included in the study. Tablet Misoprostol 600 mcg was given six hourly sublingually for 3 doses. All observations were noted and analyzed. This study was carried out NMCH Patna. Study duration One year. Conclusion: The regime had 92.85% efficacy, acceptability (90%) and few side effects. Systemic review we find that medical methods of abortion utilizing combination mifepristone and misoprostol or misoprostol alone are effective, safe and acceptable.
Files
IJPCR,Vol16,Issue5,Article248.pdf
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Additional details
Dates
- Accepted
-
2024-04-28
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue5,Article248.pdf
- Development Status
- Active
References
- 1. Philip NM, Winikoff B, Moore K, Blumenthal P. A consensusregimen for early abortion with misprostol. Int J Gynaecol Obstet 20 04; 87: 281-3. 2. Ngai SW, Chand YM, Tang O, Ho PC. Vaginalmisoprostol as medical treatment for first trimester spontaneous miscarriage. Hum Reprod 2001; 7: 1493-6. 3. Jurkovic D, Ross JA, Nicolaides KH: Expectant management of missed miscarriage. British Journal of Obstetrics and Gynaecology 1998; 105:670-71 4. Aryes-de-Campos D, Teixeria-da-Silva J et al. Vaginal misoprostol in the management for first trimester missed abortions. Int J. Gynaecol Obstet. 2000; 74: 53-57. 5. Ngoc NTN, Blum J, Westheimer E, Quan TTV, Winikoff B. Medical treatment of missed abortion using misoprostol. Int J Gynecol Obstet 2004; 87:138-42. 6. Barcelo F, Catalina De Paco Jose J. LO, PezEspi´N,Silva Y, Abad L, Parrilla JJ The management of missed miscarriage in an outpatient setting: 800 versus 600 mcg of vaginal misoprostol. Australian and New Zealand Journal of Obstetrics and Gynaecology 2012; 52: 39–43. 7. Kushwah DS, Kushwah B, Salman M T, Verma V KAcceptability and safety profile of oral and sublingual misoprostol for uterine evacuationfollowing early fetal demise Indian J Pharmacol. 2011 May-Jun; 43(3): 306–310. 8. Tang OS, Lau WN, Ng EH, Lee SW, Ho PC. A prospective randomized study to compare the use of repeated doses of vaginal with sublingual misoprostol in the management of first trimester silent miscarriages. Hum Reprod; 2003; 18 (1): 176- 81.9. Blum j, Raghavan S, Dabash R, Ngoc N, Chelli H, Haji S, Conkling k, winikoff B. comparison of misoprostol only and combined mifepriston-misoprostol regimen for home based early medical abortion in Tunisia and Vietnam .int jGynaecol obstel. 2012;118;166-71. 10. Ngoc NT, Blum J, Raghavan S, Nga NT, Dabash R, Diop A, Winikoff B. Comparing two early medical abortion regimens: mifepristone+misoprostol vs. misoprostol alone. Contraception. 2011;83(5):410–7