Evaluation of the Effectiveness of Intravenous Labetalol and Oral Nifedipine for Managing Severe Hypertension during Pregnancy
- 1. Senior Resident, Department of Obs & Gynae, NMCH, Patna
- 2. Professor & HOD, Department of Obs & Gynae, NMCH, Patna
Description
Background and Objectives: Hypertension is the most frequently encountered medical disorder in obstetric practice & remain a major cause of maternal, fetal & neonatal morbidity & mortality. The present study was undertaken to compare the time taken to reach the therapeutic goal of blood pressure after using intravenous labetolol & oral nifedipine in severe hypertension during pregnancy, To compare the efficacy and safety of the IV labetolol and oral nifedipine. Materials and Methods: Sixty women with hypertensive crisis were randomized to receive either oral nifedipine 10 mg or intravenous labetolol 20 mg in equal numbers. Oral nifedipine was given 10 mg stat followed by 10 mg every 30 minutes up to a maximum of 50 mg. Intravenous labetolol was given 20 mg stat followed by 40 mg 10 minutes later then two more doses of 80 mg every 10 minutes up to a maximum of 220 mg. The primary outcome was the number of doses required to achieve target blood pressure (BP) and time required to reduce the mean arterial pressure by 25%. Secondary outcomes analysed included additional drugs required. Conclusion: Oral nifedipine & intravenous labetolol regimens are equally effective in the management of severe hypertension in pregnancy; Nifedipine needs fewer doses to reach target BP and cost effective with the advantage of oral administration. Whereas labetolol needs less time to us reach target BP and appropriate drug in patients with eclampsia.
Abstract (English)
Background and Objectives: Hypertension is the most frequently encountered medical disorder in obstetric practice & remain a major cause of maternal, fetal & neonatal morbidity & mortality. The present study was undertaken to compare the time taken to reach the therapeutic goal of blood pressure after using intravenous labetolol & oral nifedipine in severe hypertension during pregnancy, To compare the efficacy and safety of the IV labetolol and oral nifedipine. Materials and Methods: Sixty women with hypertensive crisis were randomized to receive either oral nifedipine 10 mg or intravenous labetolol 20 mg in equal numbers. Oral nifedipine was given 10 mg stat followed by 10 mg every 30 minutes up to a maximum of 50 mg. Intravenous labetolol was given 20 mg stat followed by 40 mg 10 minutes later then two more doses of 80 mg every 10 minutes up to a maximum of 220 mg. The primary outcome was the number of doses required to achieve target blood pressure (BP) and time required to reduce the mean arterial pressure by 25%. Secondary outcomes analysed included additional drugs required. Conclusion: Oral nifedipine & intravenous labetolol regimens are equally effective in the management of severe hypertension in pregnancy; Nifedipine needs fewer doses to reach target BP and cost effective with the advantage of oral administration. Whereas labetolol needs less time to us reach target BP and appropriate drug in patients with eclampsia.
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IJPCR,Vol16,Issue5,Article239.pdf
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Additional details
Dates
- Accepted
-
2024-05-20
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue5,Article239.pdf
- Development Status
- Active
References
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