Published June 30, 2024 | Version https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue6,Article249.pdf
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Comparison of Efficacy of Local Infiltration Analgesia and Epidural Analgesia in Patients Undergoing Total Knee Arthroplasty

  • 1. Senior Resident, Department of Orthopaedics, ESIC Medical College & Hospital, Sanathnagar, Hyderabad, Telangana
  • 2. Assistant Professor, Department of Orthopaedics, Mallareddy Institute of Medical sciences, Hyderabad, Telangana
  • 3. Senior Resident, Department of Orthopaedics, Gandhi Medical College & Hospital, Secunderabad, Telangana

Description

Introduction: Total knee arthroplasty (TKA) is a common procedure for improving mobility and quality of life in patients with osteoarthritis. The present study was conducted to compare the efficacy of intra-articular infusion analgesia and epidural versus following total knee replacement. Materials and Methods: 60 patients were included in a randomized prospective study and distributed in 2 groups.  Patients in Group 1 received LIA and Group 2 EA. Patients were assessed for visual analogue score (VAS) for pain to determine the analgesic effect. Complications such as paraesthesia in the lower limbs, hypotension, urinary retention, and abdominal distension were recorded, and rehabilitation progress was recorded. Result: The pain was significantly more in EA group than in LIA group. With respect to complications, Patients with epidural infusion analgesia had a significantly higher complication rate in terms of hypotension (48% vs. 28%), paraesthesia in the lower extremities (44% vs. 12%,)  and higher abdominal distension rate (24% vs. 4%). Patients with intra-articular infusion analgesia were able to stand/ walk (2.02 vs. 3.01 days,) and climb stairs earlier (3.96 vs. 4.12 days,) which was significant. Conclusion: It was concluded that Intra-articular infusion analgesia was associated with less intensity of pain, fewer complications and earlier rehabilitation compared to epidural analgesia.

 

 

Abstract (English)

Introduction: Total knee arthroplasty (TKA) is a common procedure for improving mobility and quality of life in patients with osteoarthritis. The present study was conducted to compare the efficacy of intra-articular infusion analgesia and epidural versus following total knee replacement. Materials and Methods: 60 patients were included in a randomized prospective study and distributed in 2 groups.  Patients in Group 1 received LIA and Group 2 EA. Patients were assessed for visual analogue score (VAS) for pain to determine the analgesic effect. Complications such as paraesthesia in the lower limbs, hypotension, urinary retention, and abdominal distension were recorded, and rehabilitation progress was recorded. Result: The pain was significantly more in EA group than in LIA group. With respect to complications, Patients with epidural infusion analgesia had a significantly higher complication rate in terms of hypotension (48% vs. 28%), paraesthesia in the lower extremities (44% vs. 12%,)  and higher abdominal distension rate (24% vs. 4%). Patients with intra-articular infusion analgesia were able to stand/ walk (2.02 vs. 3.01 days,) and climb stairs earlier (3.96 vs. 4.12 days,) which was significant. Conclusion: It was concluded that Intra-articular infusion analgesia was associated with less intensity of pain, fewer complications and earlier rehabilitation compared to epidural analgesia.

 

 

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Additional details

Dates

Accepted
2024-05-26

References

  • 1. Hong KH, Pan JK, Xie H, Guo D, Yang WY, Su HT, et al. Review: Autologous blood transfusion drainage compared with no drainage in total knee arthroplasty: A meta-analysis and systematic review. Pak J Pharm Sci 2017; 30:2321-7. 2. Ahmed W, Lakdawala RH, Mohib Y, Qureshi A, Rashid RH. Does obesity affects early infection after total knee arthroplasty.A comparison of obese vs. non-obese patients. J Pak Med Assoc 2016; 66:S96-8. 3. H. Wang, B. Boctor, and J. Verner, "The effect of single-injection femoral nerve block on rehabilitation and length of hospital stay after total knee replacement," Regional Anesthesia and Pain Medicine, vol. 27, no. 2, pp. 139– 144, 2002. 4. H. Husted, T. H. Lunn, A. Troelsen, L. GaarnLarsen, B. B. Kristensen, and H. Kehlet, "Why still in hospital after fast-track hip and knee arthroplasty?" Acta Orthopaedica, vol. 82, no. 6, pp. 679–684, 2011. 5. J. Ryu, S. Saito, K. Yamamoto, and S. Sano, "Factors influencing the postoperative range of motion in total knee arthroplasty," Bulletin of the NYU Hospital for Joint Diseases, vol. 53, pp. 35– 40, 1993 6. Dalury DF, Lieberman JR, MacDonald SJ. Current and innovative pain management techniques in total knee arthroplasty. J Bone Joint Surg Am 2011; 93:1938–43. 7. Andersen KV, Bak M, Christensen BV, Harazuk J, Pedersen NA, Søballe K. A randomized, controlled trial comparing local infiltration analgesia with epidural infusion for total knee arthroplasty. Acta Orthop 2010; 81:606–10. 8. Spreng UJ, Dahl V, Hjall A, Fagerland MW, Ræder J. High-volume local infiltration analgesia combined with intravenous or local ketorolac+morphine compared with epidural an-algesia after total knee arthroplasty. Br J Anaesth 2010; 105:675–82. 9. Gómez-Cardero P, Rodríguez-Merchán EC, Postoperative analgesia in TKA: ropivacaine continuous intraarticular infusion. Clin Orthop Relat Res 2010; 468:1242–7. 10. Essving P, Axelsson K, Kjellberg J, Wallgren O, Gupta A, Lundin A. Reduced morphine consumption and pain intensity with local infiltration analgesia (LIA) following total knee arthroplasty. Acta Orthop 2010; 81:354–60. 11. Ikeuchi M, Kamimoto Y, Izumi M, Sugimura N, Takemura M, Fukunaga K, et al. Local infusion analgesia using intraarticular double lumen catheter after total knee arthroplasty: a double blinded randomized control study. Knee Surg Sports Traumatol Arthrosc 2013; 21:2680–4. 12. Zhang S, Wang F, Lu ZD, Li YP, Zhang L, Jin QH. Effect of single-injection versus continuous local infiltration analgesia after total knee arthroplasty: a randomized, double-blind, placebo-controlled study. J Int Med Res 2011; 39:1369–80. 13. Ranawat CS, Ranawat AS, Mehta A. Total knee arthroplasty rehabilitation protocol: what makes the difference? J Arthroplasty 2003; 18(3 Suppl 1):27-30. 14. Singelyn FJ, Deyaert M, Joris D, et al. Effects of intravenous patient-controlled analgesia with morphine, continuous epidural analgesia, and continuous three-in-one block on postoperative pain and knee rehabilitation after unilateral total knee arthroplasty. Anesth Analg 1998; 87(1):88-92. 15. Moen V, Dahlgren N, Irestedt L. Severe neurological complications after central neuraxial blockade in Sweden 1990-1999. Anesthesiology 2004; 101(4): 950-9. 16. Imbelloni LE, Gouveia MA, Cordeiro JA. Continuous spinal anesthesia versus combined spinal epidural block for major orthopedic surgery: prospective randomized study. Sao Paulo Med J 2009; 127(1):7-11. 17. Campbell A, McCormick M, McKinlay K, et al. Epidural vs. lumbar plexus infusions following total knee arthroplasty: randomized controlled trial. Eur J Anaesthesiol 2008; 25(6):502-7. 18. Thorsell M, Holst P, Hyldal HC, et al. Pain control after total knee arthroplasty: a prospective study comparing local infiltration anesthesia and epidural anesthesia. Orthopedics 2010; 33(2):75-80. 19. Bianconi M, Ferraro L, Traina GC, et al. Pharmacokinetics and efficacy of ropivacaine continuous wound instillation after joint replacement surgery. Br J Anaesth 2003; 91(6): 830-5. 20. Lombardi AV, Berend KR, Mallory TH, et al. Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty. Clin Orthop Relat Res 2004; (428):125-30. 21. Rasmuseen S, Kramhoft MU, Sperling KP, et al. Increased flexion and reduced hospital stay with continuous intraarticular morphine and ropivacaine after primary total knee replacement: open intervention study of efficacy and safety in 154 patients. Acta Orthop Scand 2004; 75(5):606-9. 22. Anderson KV, Bak M, Christensen BV, et al. A randomized control trial comparing local infiltration analgesia with epidural infusion for total knee arthroplasty. Acta Orthop 2010; 81(5):606-10. 23. Liu W, Cong R, Li X, et al. Reduced opioid consumption and improved early rehabilitation with local and intra articular cocktail analgesic injection in total hip arthroplasty: a randomized controlled clinical trial. Pain Med 2011; 12(3):387-93. 24. Spreng UJ, Dahl V, Hjall A, et al. Highvolume local infiltration analgesia combined with intravenous or local ketorolac plus morphine compared with epidural analgesia after total knee arthroplasty. Br J Anaesth 2010; 105(5):675-82.