Exploratory Research on the Relationship between Blood Lactate Levels and Outcomes in Children with Pneumonia
Authors/Creators
- 1. Senior Resident, Department of Paediatrics, BMIMS, Pawapuri, Nalanda
- 2. Assistant Professor, Department of Paediatrics, BMIMS, Pawapuri, Nalanda
Description
Background and Objectives: Pneumonia causes at least 18% of all child deaths globally, in some countries up to a third. Biomarkers that indicate pneumonia severity and suggest appropriate treatment or supportive care may help lower mortality. The current best predictor of pneumonia mortality risk is arterial oxygen saturation, measured by pulse oximetry. Lactate is a product of anaerobic cellular metabolism. It is used as a marker of poor tissue oxygen delivery, and cell hypoxia to monitor critically ill children, patients with severe infections, low cardiac output and acute respiratory distress syndrome. There has been not much evaluation of its role in children with pneumonia. The objective is to study the association of elevated blood lactate levels in the outcome of children with pneumonia. Methods: It is an explorative study with a total of 280 cases, aged between 2 months to 14 years admitted to BMIMS Pawapuri, hospital during the study period fulfilling the inclusion criteria were included in this study. Along with the demographic data and other investigations, using aseptic precautions 2 ml of venous blood was withdrawn and sent for lactate estimation. Conclusion: The children who died had elevated lactate concentration, hypoxia, hypotension, prolonged CFT and other signs of shock. Serum lactate measured at the time of admission, age <1 yr; hypoxia; prolonged CFT; suboptimal, feeble or low volume peripheral pulses; shock; hypotension are other strong predictors of mortality. Used in conjugation with other known risk factors like young age and hypoxemia, lactate could play a role in identifying the sick children and in their management.
Abstract (English)
Background and Objectives: Pneumonia causes at least 18% of all child deaths globally, in some countries up to a third. Biomarkers that indicate pneumonia severity and suggest appropriate treatment or supportive care may help lower mortality. The current best predictor of pneumonia mortality risk is arterial oxygen saturation, measured by pulse oximetry. Lactate is a product of anaerobic cellular metabolism. It is used as a marker of poor tissue oxygen delivery, and cell hypoxia to monitor critically ill children, patients with severe infections, low cardiac output and acute respiratory distress syndrome. There has been not much evaluation of its role in children with pneumonia. The objective is to study the association of elevated blood lactate levels in the outcome of children with pneumonia. Methods: It is an explorative study with a total of 280 cases, aged between 2 months to 14 years admitted to BMIMS Pawapuri, hospital during the study period fulfilling the inclusion criteria were included in this study. Along with the demographic data and other investigations, using aseptic precautions 2 ml of venous blood was withdrawn and sent for lactate estimation. Conclusion: The children who died had elevated lactate concentration, hypoxia, hypotension, prolonged CFT and other signs of shock. Serum lactate measured at the time of admission, age <1 yr; hypoxia; prolonged CFT; suboptimal, feeble or low volume peripheral pulses; shock; hypotension are other strong predictors of mortality. Used in conjugation with other known risk factors like young age and hypoxemia, lactate could play a role in identifying the sick children and in their management.
Files
IJPCR,Vol16,Issue6,Article211.pdf
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Additional details
Dates
- Accepted
-
2024-05-03
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue6,Article211.pdf
- Development Status
- Active
References
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