Published February 28, 2024 | Version v1
Journal article Open

A Comparative Study to Evaluate Hemodynamic Effects of Regional Anaesthesia in Preeclamptic Females Undergoing Caesarean Section

  • 1. Senior Resident, Department of Anaesthesia, Anugrah Narayan Magadh Medical College Hospital, Gaya, Bihar, India
  • 2. Associate Professor, Department of Anaesthesia, Anugrah Narayan Magadh Medical College Hospital, Gaya, Bihar, India

Description

Aim: The aim of the present study was to evaluate hemodynamic effects of regional anaesthesia in preeclamptic
females.
Methods: The observational study was conducted in the Department of Anaesthesia, Anugrah Narayan Magadh
Medical College and Hospital, Gaya , Bihar, India from march 2019 to February 2020. Study population
comprised of 100 normotensive ASA grade II parturients planned for LSCS and 100 ASA grade III preeclamptic
parturients planned for LSCS.
Results: Mean age in normotensive group was 25.35±4.36 years and in pre- eclamptic group mean age was
24.16±3.07 years. The mean weight at the time of caesarean section was 72.8±6.34 kgs in the preeclamptic group
and 74.66±7.53 kgs in preeclamptic. The mean gestational age at the time of caesarean section was 39.14±0.54
weeks in preeclamptic women and 39.07±0.77 weeks in normotensive. Majority of the study participants were
nulliparous women in both the group (55% in normotensive group v/s 68% in pre- eclamptic group) while nearly
43% of the participants in the normotensive group and 27% in pre-eclamptic group were primipara. Both groups
were comparable in term of mean age, weight, gestational age and parity comparison (p<0.05). All the nonpreeclamptic parturients were ASA II while, all parturients in the preeclamptic group were ASA III, and this
difference was statistically significant between both groups; (p< 0.001). The incidence of hypotension in nonpreeclamptic parturients (93%) was significantly higher and that of preeclamptic parturients (15%). Similarly,
bradycardia was also more commonly observed in normotensive group (32%) compared to pre-eclamptic group
(2%).
Conclusion: Subarachnoid blockade is associated with better perioperative hemodynamic stability and lower risk
of hypotension and vasopressor requirements in preeclamptic women compared to the rates of healthy subjects.
Subarachnoid block can be safely practiced in patients with preeclampsia undergoing caesarean section. The
benefit of rapid, dense and reliable subarachnoid block over epidural anaesthesia should be considered for
preeclamptics undergoing caesarean section

Abstract (English)

Aim: The aim of the present study was to evaluate hemodynamic effects of regional anaesthesia in preeclamptic
females.
Methods: The observational study was conducted in the Department of Anaesthesia, Anugrah Narayan Magadh
Medical College and Hospital, Gaya , Bihar, India from march 2019 to February 2020. Study population
comprised of 100 normotensive ASA grade II parturients planned for LSCS and 100 ASA grade III preeclamptic
parturients planned for LSCS.
Results: Mean age in normotensive group was 25.35±4.36 years and in pre- eclamptic group mean age was
24.16±3.07 years. The mean weight at the time of caesarean section was 72.8±6.34 kgs in the preeclamptic group
and 74.66±7.53 kgs in preeclamptic. The mean gestational age at the time of caesarean section was 39.14±0.54
weeks in preeclamptic women and 39.07±0.77 weeks in normotensive. Majority of the study participants were
nulliparous women in both the group (55% in normotensive group v/s 68% in pre- eclamptic group) while nearly
43% of the participants in the normotensive group and 27% in pre-eclamptic group were primipara. Both groups
were comparable in term of mean age, weight, gestational age and parity comparison (p<0.05). All the nonpreeclamptic parturients were ASA II while, all parturients in the preeclamptic group were ASA III, and this
difference was statistically significant between both groups; (p< 0.001). The incidence of hypotension in nonpreeclamptic parturients (93%) was significantly higher and that of preeclamptic parturients (15%). Similarly,
bradycardia was also more commonly observed in normotensive group (32%) compared to pre-eclamptic group
(2%).
Conclusion: Subarachnoid blockade is associated with better perioperative hemodynamic stability and lower risk
of hypotension and vasopressor requirements in preeclamptic women compared to the rates of healthy subjects.
Subarachnoid block can be safely practiced in patients with preeclampsia undergoing caesarean section. The
benefit of rapid, dense and reliable subarachnoid block over epidural anaesthesia should be considered for
preeclamptics undergoing caesarean section

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Dates

Accepted
2024-02-25