Published December 31, 2022
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Potential histopathological and immunological effects of SARS-CoV-2 on the liver
Authors/Creators
- 1. Imam Abdulrahman Bin Faisal University, College of Science, Department of Biology, Dammam, Saudi Arabia
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Alnamshan, M. M. (2022): Potential histopathological and immunological effects of SARS-CoV-2 on the liver. Brazilian Journal of Biology (e262008) 82: 1-15, DOI: 10.1590/1519-6984.262008, URL: http://dx.doi.org/10.1590/1519-6984.262008
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References
- ADAMS, D.H. and HUBSCHER, S.G., 2006. Systemic viral infections and collateral damage in the liver.American Journal of Pathology, vol. 168, no. 4, pp. 1057-1059. http://dx.doi.org/10.2353/ ajpath.2006.051296. PMid:16565481.
- AKIL, A., ENDSLEY, M., SHANMUGAM, S., SALDARRIAGA, O., SOMASUNDERAM, A.,SPRATT, H.,STEVENSON, H.L.,UTAY, N.S., FERGUSON, M. and YI, M., 2019.Fibrogenic gene expression in hepatic stellate cells induced by HCV and HIV replication in a three cell co-culture model system.Scientific Reports, vol. 9,
- ALI, N. and HOSSAIN, K., 2020. Liver injury in severe covid-19 infection: current insights and challenges. Expert Review of Gastroenterology &Hepatology, vol.14, no.10, pp. 879-884.http:// dx.doi.org/10.1080/17474124.2020.1794812. PMid:32649840.
- ALI, N., 2020. Is SARS-CoV-2 associated with liver dysfunction in COVID-19 patients? Clinics and Research in Hepatology and Gastroenterology, vol. 44, no. 4, pp. e84-e86. http://dx.doi. org/10.1016/j.clinre.2020.05.002. PMid:32471656.
- ALQAHTANI , S.A. and SCHATTENBERG, J.M., 2020. Liver injury in covid-19: the current evidence. United European Gastroenterology Journal, vol.8, no. 5, pp.509-519.http://dx.doi. org/10.1177/2050640620924157. PMid:32450787.
- AZIZ, M., FATIMA, R. and ASSALY, R., 2020. Elevated interleukin-6 and severe covid-19:a meta-analysis.Journal of Medical Virology, vol. 92, no. 11, pp. 2283-2285. http://dx.doi.org/10.1002/ jmv.25948. PMid:32343429.
- BANGASH, M.N.,PATEL , J. and PAREKH, D., 2020.Covid-19 and the liver: little cause for concern. The Lancet. Gastroenterology & Hepatology, vol.5, no. 6, pp. 529-530.http://dx.doi.org/10.1016/ S2468-1253(20)30084-4. PMid:32203680.
- BEIGMOHAMMADI, M.T.,JAHANBIN , B.,SAFAEI, M.,AMOOZADEH, L., KHOSHAVI, M.,MEHRTASH, V.,JAFARZADEH, B. andABDOLLAHI, A.,2021.Pathological findings of postmortem biopsies from lung, heart, and liver of 7 deceased covid-19 patients. International Journal of Surgical Pathology, vol.29, no. 2, pp. 135-145.http:// dx.doi.org/10.1177/1066896920935195. PMid:32552178.
- BERTOLINI, A.,VAN DE PEPPEL , I.P.andBODEWES, F.,2020.Abnormal liver function tests in covid-19 patients:relevance and potential pathogenesis. Hepatology, vol.72, no. 5, pp. 1864-1872.http:// dx.doi.org/10.1002/hep.31480. PMid:32702162.
- BIKDELI, B.,MADHAVAN, M.V.,JIMENEZ , D.,CHUICH, T.,DREYFUS, I., DRIGGIN, E.,NIGOGHOSSIAN, C.,AGENO, W.,MADJID, M.,GUO, Y., TANG , L.V.,HU, Y.,GIRI, J.,CUSHMAN, M.,QUERE, I.,DIMAKAKOS , E.P., GIBSON, C.M.,LIPPI, G.,FAVALORO, E.J.,FAREED, J.,CAPRINI , J.A., TAFUR, A.J., BURTON, J.R., FRANCESE, D.P., WANG, E.Y., FALANGA, A.,MCLINTOCK, C., HUNT, B.J., SPYROPOULOS, A.C., BARNES, G.D.,EIKELBOOM , J.W., WEINBERG, I., SCHULMAN, S., CARRIER, M.,PIAZZA, G.,BECKMAN, J.A.,STEG, P.G.,STONE, G.W., ROSENKRANZ, S., GOLDHABER, S.Z., PARIKH, S.A., MONREAL, M., KRUMHOLZ, H.M., KONSTANTINIDES, S.V., WEITZ, J.I. and LIP, G.Y.H., 2020.Covid-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up: JACC state-of-the-art review. Journal of the American College of Cardiology, vol. 75, no. 23, pp. 2950-2973. http://dx.doi.org/10.1016/j.jacc.2020.04.031. PMid:32311448.
- BLERIOT, C.andGINHOUX , F., 2019.Understanding the heterogeneity of resident liver macrophages. Frontiers in Immunology, vol. 10, p. 2694. http://dx.doi.org/10.3389/fimmu.2019.02694. PMid:31803196.
- BOYARSKY, B.J.,WERBEL, W.A.,AVERY, R.K.,TOBIAN , A.A.R.,MASSIE, A.B., SEGEV, D.L. and GARONZIK-WANG, J.M., 2021. Antibody response to 2-dose SARS-CoV-2 mRNA vaccine series in solid organ transplant recipients. Journal of the American Medical Association, vol. 325, no. 21, pp. 2204-2206. http://dx.doi. org/10.1001/jama.2021.7489. PMid:33950155.
- BRADLEY, B.T., MAIOLI, H., JOHNSTON, R., CHAUDHRY, I., FINK, S.L., XU, H., NAJAFIAN, B., DEUTSCH, G., LACY, J.M., WILLIAMS, T., YARID, N. and MARSHALL, D.A., 2020. Histopathology and ultrastructural findings of fatal covid-19 infections in Washington state: a case series.Lancet, vol.396, no. 10247, pp. 320-332. http://dx.doi.org/10.1016/S0140-6736(20)31305-2. PMid:32682491.
- CAI, Q., HUANG, D., YU, H., ZHU, Z., XIA, Z., SU, Y., LI, Z., ZHOU, G., GOU, J., QU, J., SUN, Y., LIU, Y., HE, Q., CHEN, J., LIU, L. and XU, L., 2020. Covid-19: abnormal liver function tests. Journal of Hepatology, vol.73, no. 3, pp. 566-574.http://dx.doi.org/10.1016/j. jhep.2020.04.006. PMid:32298767.
- CANTUTI-CASTELVETRI, L.,OJHA, R.,PEDRO, L.D.,DJANNATIAN , M., FRANZ, J., KUIVANEN, S., VAN DER MEER, F., KALLIO, K., KAYA, T., ANASTASINA, M., SMURA, T., LEVANOV, L., SZIROVICZA, L., TOBI, A., KALLIO-KOKKO, H., OSTERLUND, P., JOENSUU, M., MEUNIER, F.A.,BUTCHER , S.J.,WINKLER, M.S.,MOLLENHAUER, B., HELENIUS , A.,GOKCE , O.,TEESALU, T.,HEPOJOKI, J.,VAPALAHTI, O., STADELMANN, C., BALISTRERI, G. and SIMONS, M., 2020. Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science, vol.370, no.6518, pp. 856-860.http://dx.doi.org/10.1126/ science.abd2985. PMid:33082293.
- CHAI, X., HU, L., ZHANG, Y., HAN, W., LU, Z., KE, A., ZHOU, J., SHI, G., FANG, N. and FAN, J., 2020. Specific ACE2 expression in cholangiocytes may cause liver damage after 2019-nCoV infection. bioRxiv. In press.
- CHAU, T.-N., LEE, K.-C.,YAO, H., TSANG, T.-Y.,CHOW, T.-C.,YEUNG, Y.-C.,CHOI, K.-W.,TSO, Y.-K.,LAU, T.,LAI, S.-T.andLAI , C.L.,2004. SARS-associated viral hepatitis caused by a novel coronavirus: report of three cases. Hepatology, vol. 39, no. 2, pp. 302-310. http://dx.doi.org/10.1002/hep.20111. PMid:14767982.
- CHU, H., PENG, L., HU, L., ZHU, Y., ZHAO, J., SU, H., YAO, L., ZHU, Q., NIE, X., YANG, L. and HOU, X., 2021. Liver histopathological analysis of 24 postmortem findings of patients with covid-19 in China. Frontiers in Medicine, vol.8, p. 749318.http://dx.doi. org/10.3389/fmed.2021.749318. PMid:34708059.
- D'AMICO, F.E., GLAVAS, D., NOARO, G., BASSI, D., BOETTO, R., GRINGERI, E., LUCA, M. and CILLO, U., 2021. Case report: liver cysts and SARS-CoV-2: no evidence of virus in cystic fluid. Frontiers in Surgery, vol.8, p. 677889.http://dx.doi.org/10.3389/ fsurg.2021.677889. PMid:34222319.
- DAWOOD, R.M., SALUM, G.M. and EL-MEGUID, M.A., 2022. The impact of covid-19 on liver injury: covid-19 and liver injury. The American Journal of the Medical Sciences, vol. 363, no. 2, pp. 94-103. http://dx.doi.org/10.1016/j.amjms.2021.11.001. PMid:34752738.
- DENG, S.Q. and PENG, H.J., 2020. Characteristics of and public health responses to the coronavirus disease 2019 outbreak in China. Journal of Clinical Medicine, vol. 9, no. 2, p. 575. http:// dx.doi.org/10.3390/jcm9020575. PMid:32093211.
- DIAZ, L.A., IDALSOAGA, F., CANNISTRA, M., CANDIA, R., CABRERA, D., BARRERA, F.,SOZA , A.,GRAHAM, R.,RIQUELME , A.,ARRESE, M., LEISE, M.D.and ARAB, J.P., 2020.High prevalence of hepatic steatosis and vascular thrombosis in covid-19: a systematic review and meta-analysis of autopsy data. World Journal of Gastroenterology, vol. 26, no. 48, pp. 7693-7706.http://dx.doi. org/10.3748/wjg.v26.i48.7693. PMid:33505145.
- DUAN, Z.-P.,CHEN, Y.,ZHANG, J., ZHAO, J.,LANG, Z.-W.,MENG, F.-K. and BAO, X.-L., 2003.Clinical characteristics and mechanism of liver injury in patients with severe acute respiratory syndrome. Chinese Journal of Hepatology, vol. 11, no. 8, pp. 493-496. PMid:12939186.
- DUARTE-NETO, A.N.,MONTEIRO, R.A.A.,SILVA, L.F.F.,MALHEIROS , D.M.A.C., OLIVEIRA, E.P., THEODORO-FILHO, J., PINHO, J.R.R., GOMES-GOUVEA, M.S.,SALLES, A.P.M.,OLIVEIRA , I.R.S.,MAUAD, T., SALDIVA, P.H.N. and DOLHNIKOFF, M., 2020. Pulmonary and systemic involvement in covid-19 patients assessed with ultrasound-guided minimally invasive autopsy.Histopathology, vol. 77, no. 2, pp. 186-197. http://dx.doi.org/10.1111/his.14160. PMid:32443177.
- ELSOUKKARY, S.S.,MOSTYKA , M., DILLARD, A.,BERMAN, D.R., MA, L.X., CHADBURN, A.,YANTISS, R.K.,JESSURUN, J.,SESHAN , S.V., BORCZUK, A.C. and SALVATORE, S.P., 2021. Autopsy findings in 32 patients with covid-19: a single-institution experience. Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology, vol. 88, no. 1, pp. 56-68. http://dx.doi. org/10.1159/000511325. PMid:32942274.
- ESLAM, M.,SANYAL, A.J.,GEORGE, J.,SANYAL , A.,NEUSCHWANDER- TETRI, B.,TIRIBELLI, C.,KLEINER, D.E., BRUNT, E., BUGIANESI, E., YKI-JARVINEN, H.,GRONBAEK, H., CORTEZ-PINTO , H.,GEORGE, J., FAN, J.,VALENTI, L.,ABDELMALEK, M.,ROMERO-GOMEZ, M., RINELLA , M.,ARRESE , M., ESLAM, M.,BEDOSSA , P.,NEWSOME , P.N., ANSTEE, Q.M., JALAN, R., BATALLER, R., LOOMBA, R., SOOKOIAN, S., SARIN, S.K., HARRISON, S., KAWAGUCHI, T., WONG, V.W.-S., RATZIU, V., YILMAZ, Y. and YOUNOSSI, Z., 2020. MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease. Gastroenterology, vol. 158, no. 7, p. 1999-2014.e1. http://dx.doi.org/10.1053/j. gastro.2019.11.312. PMid:32044314.
- FALASCA, L., NARDACCI, R., COLOMBO, D., LALLE, E., CARO, A., NICASTRI, E., ANTINORI, A., PETROSILLO, N., MARCHIONI, L., BIAVA, G., D'OFFIZI, G., PALMIERI, F., GOLETTI, D., ZUMLA, A., IPPOLITO, G.,PIACENTINI, M. andNONNO, F., 2020.Postmortem findings in Italian patients with covid-19: a descriptive full autopsy study of cases with and without comorbidities. The Journal of Infectious Diseases, vol. 222, no. 11, pp. 1807-1815. http://dx.doi.org/10.1093/infdis/jiaa578. PMid:32914853.
- FAN, Z., CHEN, L., LI, J., CHENG, X., YANG, J., TIAN, C., ZHANG, Y., HUANG, S.,LIU, Z.andCHENG, J., 2020.Clinical features of covid- 19-related liver functional abnormality.Clinical Gastroenterology and Hepatology, vol. 18, no. 7, pp. 1561-1566. http://dx.doi. org/10.1016/j.cgh.2020.04.002. PMid:32283325.
- FASSAN, M., MESCOLI, C., SBARAGLIA, M., GUZZARDO, V., RUSSO, F.P., FABRIS, R., TREVENZOLI, M., PELIZZARO, F., CATTELAN, A.M., BASSO, C., NAVALESI, P., FARINATI, F., VETTOR, R. and TOS, A.P.D., 2021. Liver histopathology in covid-19 patients: a mono-institutional series of liver biopsies and autopsy specimens.Pathology, Research and Practice, vol.221, p. 153451. http://dx.doi.org/10.1016/j.prp.2021.153451. PMid:33932720.
- FENG, G.,ZHENG, K.I., YAN, Q.-Q.,RIOS, R.S., TARGHER, G., BYRNE, C.D., VAN POUCKE, S., LIU, W.-Y. and ZHENG, M.-H., 2020. Covid-19 and liver dysfunction:current insights and emergent therapeutic strategies. Journal of Clinical and Translational Hepatology, vol.8, no. 1, pp. 18-24.http://dx.doi.org/10.14218/ JCTH.2020.00018. PMid:32274342.
- FIEL, M.I.,JAMAL, S.M.,PANIZ-MONDOLFI , A.,GORDON, R.E.,REIDY, J., BANDOVIC, J.,ADVANI, R.,KILARU, S.,POURMAND , K.,WARD, S.,THUNG, S.N.andSCHIANO , T., 2021.Findings of hepatic severe acute respiratory syndrome coronavirus-2 infection. Cellular and Molecular Gastroenterology and Hepatology, vol. 11, no. 3, pp. 763-770. http://dx.doi.org/10.1016/j.jcmgh.2020.09.015. PMid:32992052.
- FIERRO, N.A.,2020.Covid-19 and the liver:what do we know after six months of the pandemic? Annals of Hepatology, vol. 19, no. 6, pp. 590-591.http://dx.doi.org/10.1016/j.aohep.2020.09.001. PMid:32956871.
- GARRIDO, I., LIBERAL, R. and MACEDO, G., 2020. Covid-19 and liver disease: what we know on 1st May 2020. Alimentary Pharmacology & Therapeutics, vol.52, no. 2, pp. 267-275.http:// dx.doi.org/10.1111/apt.15813. PMid:32402090.
- GAVRIATOPOULOU, M., KOROMPOKI, E., FOTIOU, D., NTANASIS- STATHOPOULOS, I., PSALTOPOULOU, T.,KASTRITIS , E., TERPOS, E.andDIMOPOULOS, M.A.,2020.Organ-specific manifestations of covid-19 infection. Clinical and Experimental Medicine, vol.
- GORDON, D.E., JANG, G.M.,BOUHADDOU, M., XU, J.,OBERNIER , K., WHITE , K.M., O'MEARA, M.J., REZELJ, V.V., GUO, J.Z., SWANEY, D.L., TUMMINO, T.A.,HUTTENHAIN, R.,KAAKE, R.M.,RICHARDS, A.L., TUTUNCUOGLU, B., FOUSSARD, H., BATRA, J., HAAS, K., MODAK, M., KIM, M., HAAS, P., POLACCO, B.J., BRABERG, H., FABIUS, J.M., ECKHARDT, M., SOUCHERAY, M., BENNETT, M.J., CAKIR, M.,MCGREGOR, M.J.,LI , Q.,MEYER, B.,ROESCH, F.,VALLET, T., KAIN, A.M., MIORIN, L., MORENO, E., NAING, Z.Z.C., ZHOU, Y., PENG, S., SHI, Y., ZHANG, Z., SHEN, W., KIRBY, I.T., MELNYK, J.E., CHORBA, J.S., LOU, K., DAI, S.A., BARRIO-HERNANDEZ, I., MEMON, D., HERNANDEZ-ARMENTA, C., LYU, J., MATHY, C.J.P., PERICA, T.,PILLA, K.B.,GANESAN, S.J.,SALTZBERG, D.J.,RAKESH, R., LIU, X.,ROSENTHAL, S.B.,CALVIELLO, L.,VENKATARAMANAN, S., LIBOY-LUGO, J., LIN, Y.,HUANG , X.-P.,LIU, Y.F.,WANKOWICZ, S.A., BOHN, M., SAFARI, M., UGUR, F.S., KOH, C., SAVAR, N.S., TRAN, Q.D., SHENGJULER, D., FLETCHER, S.J., O'NEAL, M.C., CAI, Y., CHANG, J.C.J.,BROADHURST, D.J.,KLIPPSTEN, S.,SHARP, P.P., WENZELL, N.A., KUZUOGLU-OZTURK, D., WANG, H.-Y., TRENKER, R., YOUNG, J.M., CAVERO, D.A., HIATT, J., ROTH, T.L., RATHORE, U., SUBRAMANIAN, A., NOACK, J., HUBERT, M., STROUD, R.M., FRANKEL, A.D., ROSENBERG, O.S., VERBA, K.A., AGARD, D.A.,OTT, M.,EMERMAN, M.,JURA, N.,VON ZASTROW, M., VERDIN, E., ASHWORTH, A., SCHWARTZ, O., D'ENFERT, C., MUKHERJEE, S., JACOBSON, M., MALIK, H.S., FUJIMORI, D.G., IDEKER, T., CRAIK, C.S., FLOOR, S.N., FRASER, J.S., GROSS, J.D., SALI, A.,ROTH , B.L.,RUGGERO, D.,TAUNTON , J., KORTEMME, T., BELTRAO , P.,VIGNUZZI , M.,GARCIA-SASTRE, A.,SHOKAT, K.M., SHOICHET, B.K. and KROGAN, N.J., 2020.A SARS-CoV-2protein interaction map reveals targets for drug repurposing. Nature, vol. 583, no. 7816, pp. 459-468. http://dx.doi.org/10.1038/ s41586-020-2286-9. PMid:32353859.
- GUICCIARDI, M.E. andGORES, G.J.,2005.Apoptosis: a mechanism of acute and chronic liver injury.Gut, vol.54, no. 7, pp. 1024-1033. http://dx.doi.org/10.1136/gut.2004.053850 . PMid:15951554.
- HAMMING, I., TIMENS , W., BULTHUIS, M.L.C.,LELY, A.T.,NAVIS, G.J. and VAN GOOR, H., 2004. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis.The Journal of Pathology, vol. 203, no. 2, pp. 631-637. http://dx.doi.org/10.1002/path.1570. PMid:15141377.
- HAN, D., FANG, Q. and WANG, X., 2021. SARS-CoV-2 was found in the bile juice from a patient with seve2re covid-19. Journal of Medical Virology, vol. 93, no. 1, pp. 102-104. http://dx.doi. org/10.1002/jmv.26169. PMid:32530522.
- HICKLEY, N.M.,AL-MASKARI, A.andMCKIBBIN, M., 2011.Chloroquine and hydroxychloroquine toxicity. Archives of Ophthalmology, vol. 129, no. 11, pp. 1506-1507. http://dx.doi.org/10.1001/ archophthalmol.2011.321. PMid:22084231.
- HOEHL, S., RABENAU, H., BERGER, A.,KORTENBUSCH, M., CINATL, J., BOJKOVA, D., BEHRENS, P., BODDINGHAUS, B., GOTSCH, U., NAUJOKS, F., NEUMANN, P., SCHORK, J., TIARKS-JUNGK, P., WALCZOK, A., EICKMANN, M., VEHRESCHILD, M.J.G.T., KANN, G., WOLF, T., GOTTSCHALK, R. and CIESEK, S., 2020. Evidence of SARS-CoV-2 infection in returning travelers from Wuhan, China. The New England Journal of Medicine, vol. 382, no. 13, pp. 1278-1280. http://dx.doi.org/10.1056/NEJMc2001899. PMid:32069388.
- HOFFMANN, M., KLEINE-WEBER, H., KRUGER, N., MULLER, M., DROSTEN, C.and POHLMANN, S., 2020a.The novel coronavirus (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells. bioRxiv. In press.
- HOFFMANN, M., KLEINE-WEBER , H., SCHROEDER, S., KRUGER, N., HERRLER, T.,ERICHSEN, S.,SCHIERGENS , T.S.,HERRLER, G.,WU, N.H., NITSCHE, A.,MULLER, M.,DROSTEN, C.andPOHLMANN, S., 2020b.SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell, vol. 181, no. 2, pp. 271-280.e8. http://dx.doi.org/10.1016/j. cell.2020.02.052. PMid:32142651.
- HORVATITS, T., TRAUNER, M. and FUHRMANN, V., 2013. Hypoxic liver injury and cholestasis in critically ill patients. Current Opinion in Critical Care, vol. 19, no. 2, pp. 128-132. http:// dx.doi.org/10.1097/MCC.0b013e32835ec9e6. PMid:23403733.
- JI, D., QIN, E., XU, J., ZHANG, D., CHENG, G., WANG, Y. and LAU, G., 2020. Non-alcoholic fatty liver diseases in patients with covid-19: a retrospective study.Journal of Hepatology, vol. 73, no. 2, pp.451-453.http://dx.doi.org/10.1016/j.jhep.2020.03.044. PMid:32278005.
- JIN, X., LIAN, J.S., HU, J.H., GAO, J., ZHENG, L., ZHANG, Y.M., HAO, S.R., JIA, H.Y., CAI, H., ZHANG, X.L., YU, G.D., XU, K.J., WANG, X.Y., GU, J.Q., ZHANG, S.Y., YE, C.Y., JIN, C.L., LU, Y.F., YU, X., YU, X.P., HUANG, J.R., XU, K.L., NI, Q., YU, C.B., ZHU, B., LI, Y.T., LIU, J., ZHAO, H., ZHANG, X., YU, L., GUO, Y.Z., SU, J.W., TAO, J.J., LANG, G.J., WU, X.X., WU, W.R., QV, T.T., XIANG, D.R., YI, P., SHI, D., CHEN, Y., REN, Y., QIU, Y.Q., LI, L.J., SHENG, J. and YANG, Y., 2020.Epidemiological,clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (covid-19) with gastrointestinal symptoms. Gut, vol. 69, no. 6, pp. 1002-1009. http://dx.doi.org/10.1136/gutjnl-2020-320926. PMid:32213556.
- KRENKEL, O. and TACKE, F., 2017. Liver macrophages in tissue homeostasis and disease. Nature Reviews. Immunology, vol. 17, no. 5, pp. 306-321. http://dx.doi.org/10.1038/nri.2017.11. PMid:28317925.
- KUKLA, M.,SKONIECZNA- Z YDECKA, K.,KOTFIS, K.,MACIEJEWSKA , D., LONIEWSKI, I.,LARA , L.,PAZGAN-SIMON, M.,STACHOWSKA , E., KACZMARCZYK, M., KOULAOUZIDIS, A. and MARLICZ, W., 2020.Covid-19,MERS and SARS with concomitant liver injury: systematic review of the existing literature. Journal of Clinical Medicine, vol. 9, no. 5, p. 1420. http://dx.doi.org/10.3390/ jcm9051420. PMid:32403255.
- KULKARNI, A.V.,KUMAR , P.,TEVETHIA, H.V.,PREMKUMAR, M.,ARAB, J.P., CANDIA, R., TALUKDAR, R., SHARMA, M., QI, X., RAO, P.N. and REDDY, D.N., 2020.Systematic review with meta-analysis: liver manifestations and outcomes in covid-19. Alimentary Pharmacology & Therapeutics, vol.52, no. 4, pp. 584-599.http:// dx.doi.org/10.1111/apt.15916. PMid:32638436.
- LAGANA, S.M., KUDOSE, S., IUGA, A.C., LEE, M.J., FAZLOLLAHI, L., REMOTTI, H.E.,PORTILLO, A.,MICHELE, S.,GONZALEZ, A.K.,SAQI, A., KHAIRALLAH, P., CHONG, A.M.,PARK, H., UHLEMANN, A.C., LEFKOWITCH, J.H. and VERNA, E.C., 2020a. Hepatic pathology in patients dying of covid-19: a series of 40 cases including clinical, histologic, and virologic data. Modern Pathology, vol. 33, no. 11, pp. 2147-2155. http://dx.doi.org/10.1038/s41379- 020-00649-x. PMid:32792598.
- LAGANA, S.M., MICHELE, S., LEE, M.J., EMOND, J.C., GRIESEMER, A.D., TULIN-SILVER, S.A., VERNA, E.C., MARTINEZ, M. and LEFKOWITCH, J.H., 2020b. Covid-19 associated hepatitis complicating recent living donor liver transplantation.Archives of Pathology & Laboratory Medicine, vol.144, no. 8, pp. 929-932. http://dx.doi.org/10.5858/arpa.2020-0186-SA. PMid:32302212.
- LAX, S.F., SKOK, K., ZECHNER, P., KESSLER, H.H., KAUFMANN, N., KOELBLINGER, C.,VANDER, K.,BARGFRIEDER , U.and TRAUNER, M., 2020. Pulmonary arterial thrombosis in covid-19 with fatal outcome: results from a prospective, single-center, clinicopathologic case series. Annals of Internal Medicine, vol.
- 173, no. 5, pp. 350-361. http://dx.doi.org/10.7326/M20-2566. PMid:32422076.
- LEI, F., LIU, Y., ZHOU, F., QIN, J., ZHANG, P., ZHU, L., ZHANG, X., CAI, J., LIN, L., OUYANG, S., WANG, X., YANG, C.,CHENG , X., LIU, W., LI, H., XIE, J., WU, B., LUO, H., XIAO , F.,CHEN, J., TAO, L., CHENG, G., SHE, Z.G., ZHOU, J., WANG, H., LIN, J., LUO, P., FU, S., ZHOU, J., YE, P., XIAO, B., MAO, W., LIU, L., YAN, Y., LIU, L., CHEN, G., LI, H., HUANG, X., ZHANG, B.H. and YUAN, Y., 2020. Longitudinal association between markers of liver injury and mortality in covid-19 in China. Hepatology, vol. 72, no. 2, pp. 389-398. http://dx.doi.org/10.1002/hep.31301. PMid:32359177.
- LENG, L., CAO, R., MA, J., MOU, D., ZHU, Y., LI, W., LV, L., GAO, D., ZHANG, S., GONG, F., ZHAO, L., QIU, B., XIANG, H., HU, Z., FENG, Y., DAI, Y., ZHAO, J., WU, Z., LI, H. and ZHONG, W., 2020. Pathological features of covid-19-associated lung injury: a preliminary proteomics report based on clinical samples.Signal Transduction and Targeted Therapy, vol. 5, no. 1, p. 240. http:// dx.doi.org/10.1038/s41392-020-00355-9. PMid:33060566.
- LI, J. and FAN, J.G., 2020. Characteristics and mechanism of liver injury in 2019 coronavirus disease. Journal of Clinical and Translational Hepatology, vol. 8, no. 1, pp. 13-17. http://dx.doi. org/10.14218/JCTH.2020.00019. PMid:32274341.
- LI, Q., WANG, J., ZHOU, X., LU, H., LU, M. and HUANG, L., 2021.Case report: viral pneumonia could prompt the advancement of immune-mediated liver disease. Frontiers in Medicine, vol. 8, p. 582620. http://dx.doi.org/10.3389/fmed.2021.582620. PMid:34079806.
- LI, Y. and XIAO, S., 2020.Hepatic involvement in covid-19 patients: pathology, pathogenesis, and clinical implications. Journal of Medical Virology, vol. 92, no. 9, pp. 1491-1494. http://dx.doi. org/10.1002/jmv.25973. PMid:32369204.
- LIU, J., LI, S., LIU, J., LIANG, B., WANG, X., WANG, H., LI, W., TONG, Q., YI, J., ZHAO, L., XIONG, L., GUO, C., TIAN, J., LUO, J., YAO, J., PANG, R., SHEN, H., PENG, C., LIU, T., ZHANG, Q., WU, J., XU, L., LU, S., WANG, B., WENG, Z., HAN, C., ZHU, H., ZHOU, R., ZHOU, H., CHEN, X., YE, P., ZHU, B., WANG, L., ZHOU, W., HE, S., HE, Y., JIE, S., WEI, P., ZHANG, J., LU, Y., WANG, W., ZHANG, L., LI, L., ZHOU, F., WANG, J., DITTMER, U., LU, M., HU, Y., YANG, D. and ZHENG, X., 2020. Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients.EBioMedicine, vol.55, p. 102763. http://dx.doi.org/10.1016/j.ebiom.2020.102763. PMid:32361250.
- MANGALMURTI, N. and HUNTER, C.A., 2020. Cytokine storms: understanding covid-19. Immunity, vol. 53, no. 1, pp. 19-25. http://dx.doi.org/10.1016/j.immuni.2020.06.017. PMid:32610079.
- MARJOT, T.,MOON, A.M.,COOK, J.A.,ABD-ELSALAM , S.,ALOMAN, C., ARMSTRONG , M.J.,POSE , E.,BRENNER, E.J.,CARGILL, T.,CATANA , M.-A.,DHANASEKARAN, R.,ESHRAGHIAN , A.,GARCIA-JUAREZ, I., GILL, U.S.,JONES, P.D.,KENNEDY, J.,MARSHALL, A.,MATTHEWS, C., MELLS, G.,MERCER , C.,PERUMALSWAMI, P.V.,AVITABILE, E., QI , X., SU, F., UFERE, N.N., WONG, Y.J., ZHENG, M.-H., BARNES, E., BARRITT IV, A.S. and WEBB, G.J., 2021. Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: an international registry study. Journal of Hepatology, vol. 74, no. 3, pp. 567-577. http://dx.doi.org/10.1016/j.jhep.2020.09.024. PMid:33035628.
- MATSUYAMA, S., NAO, N., SHIRATO, K., KAWASE, M., SAITO, S., TAKAYAMA, I., NAGATA, N., SEKIZUKA, T., KATOH, H., KATO, F., SAKATA, M., TAHARA, M., KUTSUNA, S., OHMAGARI, N., KURODA, M.,SUZUKI , T.,KAGEYAMA , T. and TAKEDA, M., 2020. Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells. Proceedings of the National Academy of Sciences of the United