Comparative Study of Intubating Condition and Duration of Action After Administration of Rocuronium Bromide and Vecuronium Bromide in Abdominal Surgery using a Train of Four
Creators
- 1. Assistant Professor, Department of Anaesthesiology, S.C.B. Medical College, Cuttack, Odisha, India
Description
Background: In this study, we wanted to compare vecuronium bromide and rocuronium bromide using TOF on adductor pollicis muscles with regard to the time of onset, conditions of tracheal intubation, and duration of action. We also wanted to compare the hemodynamic parameters in the patients under anaesthesia where either of the drugs was used to produce muscular paralysis. Methods: This was a hospital-based study conducted among 60 patients who presented with various types of elective abdominal surgical procedures to S.C.B. Medical College & Hospital, Cuttack, Odisha from January 2021 to December 2022 for a period of 2 years, after obtaining clearance from the institutional ethics committee and written informed consent from the study participants. Results: In a comparison of the meantime for the onset of action between the two groups here, the mean (SD) onset of action in group A (Rocuronium) was 98.60 (7.578) sec and group B (Vecuronium) was 154.80 (20.400) sec, which was statistically highly significant (t value -14.145 and P value 0.000). Conclusion: The advantage of Rocuronium, with its early onset of action, along with good to excellent intubating conditions and cardiovascular stability, makes this neuromuscular relaxant a safe and desirable choice for tracheal intubation in surgical procedures requiring general anaesthesia when there is no anticipated difficulty in intubation.
Abstract (English)
Background: In this study, we wanted to compare vecuronium bromide and rocuronium bromide using TOF on adductor pollicis muscles with regard to the time of onset, conditions of tracheal intubation, and duration of action. We also wanted to compare the hemodynamic parameters in the patients under anaesthesia where either of the drugs was used to produce muscular paralysis. Methods: This was a hospital-based study conducted among 60 patients who presented with various types of elective abdominal surgical procedures to S.C.B. Medical College & Hospital, Cuttack, Odisha from January 2021 to December 2022 for a period of 2 years, after obtaining clearance from the institutional ethics committee and written informed consent from the study participants. Results: In a comparison of the meantime for the onset of action between the two groups here, the mean (SD) onset of action in group A (Rocuronium) was 98.60 (7.578) sec and group B (Vecuronium) was 154.80 (20.400) sec, which was statistically highly significant (t value -14.145 and P value 0.000). Conclusion: The advantage of Rocuronium, with its early onset of action, along with good to excellent intubating conditions and cardiovascular stability, makes this neuromuscular relaxant a safe and desirable choice for tracheal intubation in surgical procedures requiring general anaesthesia when there is no anticipated difficulty in intubation.
Files
IJPCR,Vol15,Issue3,Article100.pdf
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Additional details
Dates
- Accepted
-
2023-03-15
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue3,Article100.pdf
- Development Status
- Active
References
- 1. Sehgal A, Sharma RK, Hemant KI. Comparison of intubating conditions and time course of action of rocuronium bromide and vecuronium bromide. IJA. 2001; 45:255. 2. Booth MG, Marsh B, Bryden FM, Robertson EN, Baird WL. A comparison of pharmacodynamics of rocuronium and vecuronium during halothane anaesthesia. Anaesthesia. 199 2;47(10):832-4. 3. Scheiber G, Ribeiro FC, Marichal A, Bredendiek M, Renzing K. Intubating conditions and onset of action after rocuronium vecuronium, and atracurium in young children. Anesth Analg. 1996;83(2):320-4. 4. Lin PL, Liu CC, Fan SZ, Chao A, Shin SC, Tai YT. Comparison of neuromuscular action of Rocuronium: a new steroidal non-depolarizing agent, with Vecuronium. Acta Anaesthesiol Scand. 1997;35(3):127-31. 5. Smith I, Saad RS. Comparison of intubating conditions after rocuronium or vecuronium when the timing of intubation is judged by clinical criteria. Br J Anaesth. 1998;80(2):235-7. 6. Vishwas S, Sivashankar KR, Sharma RC, Gangawane AK. Comparison of intubating conditions with rocuronium and vecuronium at specific times judged by clinical criteria. Neurosc - ience Research. 2010;1(1):9-25. 7. Patel DD, Swadia VN. Rocuronium bromide versus vecuronium bromide: Comparision of onset, intubating condition and duration of action. Int J Res Med. 2013; 2:137-41. 8. Somani M, Sharma P, Sachdev S, Mathur V, Chaturvedi S. A comparative study between vecuronium and rocuronium for intubating condition and hemodynamic changes. IOSR J Dent Med Sci. 2014; 13:33-9. 9. Parasa M, Vemuri NN, Shaik MS. Comparison of equipotent doses of rocuronium and vecuronium. Anesth Essays Res. 2015;9(1):88-91. 10. Suresh SN, Singh NG. Comparison between adductor pollicis and orbicularis oculi as indicators of adequacy of muscle relaxation for tracheal intubation following rocuronium induced neuromuscular block: randomized comparative clinical trial. Recent Research in Science and Technology. 2010;2(5). 11. Xue FS, Liao X, Liu JH, Tong SY, Zhang Y, Zhang RJ, et al. A comparative study of the doseresponse and time course of action of rocuronium and vecuronium in anesthetized adult. J Clin Anesth. 1998; 10(5):410-5. 12. Tullock WC, Diana P, Cook DR, Wilks DH, Brandom BW, Stiller RL, et al. Neuromuscular and cardiovascular effects of high dose Vecuronium. Anaesth Analg. 1990; 70 (1):86-90. 13. Magorian T, Flannery KB, Miller RD. Comparison of rocuronium, succinylcholine, and vecuronium for rapid-sequence induction of anesthesiain adult patients. Anesthesiology. 1993; 79(5):913-8. 14. Lee HJ, Kim KS, Jeong JS, Cheong MA, Shim JC. Comparison of the adductor pollicis, orbicularis oculi, and corrugator supercilii as indicators of adequacy of muscle relaxation for tracheal intubation. Br J Anaesth. 2009; 102(6):869-74. 15. Cooper R, Mirakhur RK, Clarke RS, Boules Z. Comparison of intubating condition after administration of org 9426 (Rocuronium) and Suxametho nium. Br J Anaesth. 1992;69 (3):269- 73 16. Mirakhur RK. Newer neuromuscular blocking drugs: An overview of their clinical pharmacology and therapeutic use. Drugs. 1992;44(2):182-99. 17. Wierda JM, Hommes FD, Nap HJ, Van den Broek L. Time course of action and intubating conditions following vecuronium, rocuronium and mivacurium. Anaesthesia. 1995;50(5): 393-6. 18. Van den Broek L, Hommes FD, Nap HJ, Wierda JM. Rocuronium and mivacurium induced neuromuscular block and intubating conditions: A comparison with Vecuronium. Eur J Anaesthesiol Suppl. 1995; 11:27-30. 19. Shukla A, Dubey KP, Sharma MS. Comparative evaluation of haemodynamic effects and intubating conditions after the administration of org 9426 (rocuronium) and succinyl choline. Indian J Anaesth. 2004;48 (6): 476-9. 20. Russo R, Veschi G, Dellino E, Ciceri R, Iapichino G. Onset time and duration of action of neuromuscular block induced by increasing doses of Vecuronium bromide. Minerva Anesthesiol. 1993;59 (1-2): 35-8. 21. Nitschmann P, Oberkogler W, Hertsig M, Schwarz S. Comparison of haemodynamic effects of Rocuronium bromide with those of Vecuronium in patients undergoing CABG surgery. Eur J Anaesthesiol. 1994;9 (Suppl.):11 3-5. 22. Lee H, Jeong S, Choi C, Jeong H, Lee S, Jeong S. Anesthesiologist's satisfaction using between cisatracurium and rocuronium for the intubation in the anesthesiainduced by remifentanil and propofol. Korean J Anesthesiol. 2013; 64(1):34-9. 23. Dwivedi MB, Kaur S, Jindal R, Dwivedi S. A comparative study to evaluate the efficacy of rocuronium and vecuronium for rapid sequence intubation in adults. Journal of Evolution of Medical and Dental Sciences. 2015;4(45):7741-7.