Phytochemical Investigation and Molecular Modelling of Steroidal Glycoalkaloid from Solanum Xanthocarpum
Authors/Creators
- 1. K.J College of Pharmacy, At & Po.,Vadasma, Dist., Mehsana, Gujarat, India
- 2. L.M.College of Pharmacy, Dept. of Pharmaceutical Chemistry, Ahmedabad
Description
The kantakari having a botanical name is Solanum xanthocarpum, synonym Solanum
surattense and it belongs to family solanaceae. A dried ripe berries containing more amount
of glycoalkaloid compare to all parts of the plant. Glycoalkaloids consist of perhydro 1, 2-
cyclopentanophenanthrene nucleus, the solanum alkaloid having N- analog of steroidal
saponins. The isolated compounds were evaluated by physical and chemical methodsand
further elucidated by analytical specification using UV, Infrared and Mass spectroscopic
methods. Molecular Modelling and comparison study used as a pottasium sparing diuretic
and the isolated , the 3D compound ,structure of the spironolactone and solasodine were
generated, energy minimized and superimposed using software, finaly determine RMSD for
both spiranolactone and isolated compound having a low value that shown spironolactone
and solasodine had a structural similarity so solasodine gave pharmacological action similar
to spironolactone.
Abstract (English)
The kantakari having a botanical name is Solanum xanthocarpum, synonym Solanum
surattense and it belongs to family solanaceae. A dried ripe berries containing more amount
of glycoalkaloid compare to all parts of the plant. Glycoalkaloids consist of perhydro 1, 2-
cyclopentanophenanthrene nucleus, the solanum alkaloid having N- analog of steroidal
saponins. The isolated compounds were evaluated by physical and chemical methodsand
further elucidated by analytical specification using UV, Infrared and Mass spectroscopic
methods. Molecular Modelling and comparison study used as a pottasium sparing diuretic
and the isolated , the 3D compound ,structure of the spironolactone and solasodine were
generated, energy minimized and superimposed using software, finaly determine RMSD for
both spiranolactone and isolated compound having a low value that shown spironolactone
and solasodine had a structural similarity so solasodine gave pharmacological action similar
to spironolactone.
Files
IJCPR,Vol2,Issue1,Article2.pdf
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Additional details
Dates
- Accepted
-
2011-04-01