Purine and pyrimidine nucleotide biosynthesis

Synthesis which is permiting purine and pyrimidine analogs with potential as anticancer drugs to be incorporated into DNA. The most important regulator of de novo purine biosynthesis is the intracellular concentration of phosphoribosyl-pyrophosphate. The synthesis rates of purine and pyrimidine oxyribonucleotides and deoxyribonucleotides for parameters determination in cross regulation. Liver is a major site of purine nucleotide synthesis and provides purines in the form of bases or nucleosides to be salvaged and utilized by those tissues’ incapable of synthetizing purines. In this paper the catalytic activity of phosphoribosyl-pyrophosphate synthetase was studied.