Basic Concepts of Therapeutic Drug Monitoring
Authors/Creators
- 1. Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry – 60 5502, India.
Description
Therapeutic Drug Monitoring (TDM) is the process of measuring the concentration of a drug
in blood and then correlating it clinically in order to optimize the therapy for the patient. It
started in the 1960s and the last three decades have seen enormous spurt in the number of
hospitals and laboratories routinely doing it in order to provide greater insights into factors that
determine a patient’s response to drug therapy. It is done mainly for drugs with narrow margin
of safety, whose therapeutic effects cannot be quantified clinically. Suitable analytical tests like
High Performance Liquid Chromatography (HPLC) and Immunoassays are available to detect
drug or its metabolites and the results are then interpreted in the context of the condition of the
patient. It serves as a useful tool to provide tailor made optimal drug therapy to the patient,
thereby maximizing the efficacy and minimizing the side effects.
Abstract (English)
Therapeutic Drug Monitoring (TDM) is the process of measuring the concentration of a drug
in blood and then correlating it clinically in order to optimize the therapy for the patient. It
started in the 1960s and the last three decades have seen enormous spurt in the number of
hospitals and laboratories routinely doing it in order to provide greater insights into factors that
determine a patient’s response to drug therapy. It is done mainly for drugs with narrow margin
of safety, whose therapeutic effects cannot be quantified clinically. Suitable analytical tests like
High Performance Liquid Chromatography (HPLC) and Immunoassays are available to detect
drug or its metabolites and the results are then interpreted in the context of the condition of the
patient. It serves as a useful tool to provide tailor made optimal drug therapy to the patient,
thereby maximizing the efficacy and minimizing the side effects.
Files
IJCPR,Vol5,Issue4,Article1.pdf
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Additional details
Dates
- Accepted
-
2014-11-01