CHEMOTHERAPEUTIC AGENTS: TAXOL AND VINCRISTINE ISOLATED FROM ENDOPHYTIC FUNGI
Authors/Creators
- 1. Institute of Natural and Applied Sciences (Fen Bilimleri Enstitüsü), Department of Biotechnology, Çukurova University, Saricam ilcesi, 01330 Balcali, Adana, Turkey.
- 2. Faculty of Industrial Sciences and Technology, Department of Biotechnology, Universiti Malaysia Pahang (UMP), 26300 Gambang, Kuantan, Malaysia.
Description
Endophytic fungi are abundant and have been found asymptomatically in most plants species. Endophytic fungi are
considered as hidden members of the microbial world and represent an under-utilized resource of natural bioactive
compounds for agricultural, industrial and medicinal uses. As reported previously, several valuable natural products with
anticancer, antimicrobial, and insecticidal properties have been successfully extracted from the endophytic fungi.
Chemotherapy yields the first promise of destroying cancer cells that has distributed into the body. This is due to the fact
that chemotherapeutic agents overlap with the process of dividing cancer cells, which in turn leads to establishing new
cells. Vincristine (vinca alkaloids) and podophyllotoxin prohibit the microtubules polymerization at high drug
concentrations whereas Taxol™ and Taxotere stimulate the microtubules polymerization and stabilize the microtubules as
well at high concentrations. In This review, we critically attempt to summarize the mechanisms of the cancer
chemotherapeutic drugs, namely, Taxol and Vincristine (vinca alkaloids) on the need for more the research in the field of
cancer chemotherapy.
Abstract (English)
Endophytic fungi are abundant and have been found asymptomatically in most plants species. Endophytic fungi are
considered as hidden members of the microbial world and represent an under-utilized resource of natural bioactive
compounds for agricultural, industrial and medicinal uses. As reported previously, several valuable natural products with
anticancer, antimicrobial, and insecticidal properties have been successfully extracted from the endophytic fungi.
Chemotherapy yields the first promise of destroying cancer cells that has distributed into the body. This is due to the fact
that chemotherapeutic agents overlap with the process of dividing cancer cells, which in turn leads to establishing new
cells. Vincristine (vinca alkaloids) and podophyllotoxin prohibit the microtubules polymerization at high drug
concentrations whereas Taxol™ and Taxotere stimulate the microtubules polymerization and stabilize the microtubules as
well at high concentrations. In This review, we critically attempt to summarize the mechanisms of the cancer
chemotherapeutic drugs, namely, Taxol and Vincristine (vinca alkaloids) on the need for more the research in the field of
cancer chemotherapy.
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IJCPR,Vol6,Issue1,Article10.pdf
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Additional details
Dates
- Accepted
-
2015-01-01