To Evaluate the Effect of Second-Line Anti-Retroviral Therapy on Blood Sugar in Patients with Human Immunodeficiency Virus (HIV) - Acquired Immune Deficiency Syndrome (AIDS)
Creators
- 1. Resident Doctor, JLN Medical College, Ajmer, Rajasthan
- 2. Associate Professor, JLN Medical College, Ajmer, Rajasthan
- 3. Senior Professor, JLN Medical College, Ajmer, Rajasthan
- 4. Resident Doctor, JLNMC, Ajmer, Rajasthan
Description
Background: To evaluate the effect of second-line anti-retroviral therapy on blood sugar in patients with human immunodeficiency virus (HIV) – acquired immune deficiency syndrome (AIDS). Methods: This prospective study was carried out at a tertiary care hospital among 100 HIV infected patients who had failed on First line and started on Second-line HAART, formed the cases of the study and registered at ART centre. Ethical approval was obtained from the Institutional Ethical Committee of this institution. Results: Average FBS of the study population was 89.95mg/dl at the baseline. However, it increased with the course of treatment over the time. It was observed that the mean FBS raised to 103.18mg/dl in 6 months and 115.28mg/dl in 12 months. This difference was statistically significant (P<0.0001). Average HBA1c of the studied subjects was 5.65% at the baseline. However, it increased with the course of treatment over the time. It was observed that the mean HBA1c raised to 6.02% in 6 months and 6.46% in 12 months. This difference was found to be statistically significant (P<0.0001). Conclusion: In our study it was found that second line ART along with its duration is a significant risk factor for development of Hyperglycemia. Hence timely screening should be done for FBS in patient who are on second line ART so that we can prevent and timely manage the Metabolic complications.
Abstract (English)
Background: To evaluate the effect of second-line anti-retroviral therapy on blood sugar in patients with human immunodeficiency virus (HIV) – acquired immune deficiency syndrome (AIDS). Methods: This prospective study was carried out at a tertiary care hospital among 100 HIV infected patients who had failed on First line and started on Second-line HAART, formed the cases of the study and registered at ART centre. Ethical approval was obtained from the Institutional Ethical Committee of this institution. Results: Average FBS of the study population was 89.95mg/dl at the baseline. However, it increased with the course of treatment over the time. It was observed that the mean FBS raised to 103.18mg/dl in 6 months and 115.28mg/dl in 12 months. This difference was statistically significant (P<0.0001). Average HBA1c of the studied subjects was 5.65% at the baseline. However, it increased with the course of treatment over the time. It was observed that the mean HBA1c raised to 6.02% in 6 months and 6.46% in 12 months. This difference was found to be statistically significant (P<0.0001). Conclusion: In our study it was found that second line ART along with its duration is a significant risk factor for development of Hyperglycemia. Hence timely screening should be done for FBS in patient who are on second line ART so that we can prevent and timely manage the Metabolic complications.
Files
IJPCR,Vol15,Issue4,Article165.pdf
Files
(302.3 kB)
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Additional details
Dates
- Accepted
-
2023-04-13
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue4,Article165.pdf
- Development Status
- Active
References
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