Published July 9, 2024 | Version v2
Journal article Open

Summary statistics of the X-chromosome for 2,822 brain imaging traits in UKB (n = 34,000)

Creators

  • 1. Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
  • 2. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
  • 3. Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • 4. Department of Statistics and Data Science, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • 5. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • 6. Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • 7. Department of Public Health Sciences, Penn State University, Hershey, PA 17033, USA.
  • 8. Department of Statistical Sciences, University of Toronto, Toronto, ON M5G 1Z5, Canada.

Description

This deposit hosts X-chromosome association summary statistics using 34,000 UKB white subjects for 2,822 brain imaging traits, including 101 regional brain volume traits, 63 cortical thickness traits, 66 surface area traits, 525 DTI PC traits, 110 DTI tract-mean traits, 1,777 ICA resting-state functional MRI (rfMRI) traits, 90 Glasser360 mean-level rfMRI traits, and 90 Glasser360 mean-level task-evoked functional MRI (trfMRI) traits.

The shared data includes:

1. sex-agnostic association analysis for X-chr (PAR and NPR)

2. sex-stratified association analysis for X-chr (PAR and NPR)

The corresponding article: Jiang, Zhiwen, et al. "The pivotal role of the X-chromosome in the genetic architecture of the human brain." medRxiv (2023): 2023-08.

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Additional details

Related works

Is supplement to
Preprint: 10.1101/2023.08.30.23294848 (DOI)

Dates

Updated
2024-07-09
Uploaded sex-stratified summary statistics

References

  • Jiang, Zhiwen, et al. "The pivotal role of the X-chromosome in the genetic architecture of the human brain." medRxiv (2023): 2023-08.