Synthesis, Characterization and Antioxidant Activity of Morpholine Mannich Base Derivatives
Authors/Creators
- 1. Centre for Medicinal Chemistry, Delhi Pharmaceutical Sciences and Research University, Sector-3, Pushp Vihar, New Delhi, India
- 2. Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research, Sector-3, Pushp Vihar, New Delhi, India
Description
A series of morpholine mannich base derivatives were synthesized by a single step reaction of morpholine with substituted
benzaldehydes and N-phenylacetamide. Progress of reaction was monitored by TLC using ethylacetate and n-hexane as
mobile phase. The compounds were characterized by ATR and 1HNMR spectral analysis. Antioxidant assay of the
synthesized compounds was done by DPPH and ABTS assay method using Ascorbic acid as standard. The synthesized
morpholine mannich base derivatives demonstrated significant radical scavenging property.
Abstract (English)
A series of morpholine mannich base derivatives were synthesized by a single step reaction of morpholine with substituted
benzaldehydes and N-phenylacetamide. Progress of reaction was monitored by TLC using ethylacetate and n-hexane as
mobile phase. The compounds were characterized by ATR and 1HNMR spectral analysis. Antioxidant assay of the
synthesized compounds was done by DPPH and ABTS assay method using Ascorbic acid as standard. The synthesized
morpholine mannich base derivatives demonstrated significant radical scavenging property.
Files
IJCPR,Vol8,Issue5,Article3.pdf
Files
(428.0 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:0f2fd3381e3de4b4f4e9376776d9bb77
|
428.0 kB | Preview Download |
Additional details
Dates
- Accepted
-
2017-10-25