Synthesis and Biological Evaluation of Chalconyl Incorporated Schiff's Bases of Sulphonamides
Creators
- 1. Geetanjali Institute of Pharmacy, Udaipur 313001, India
- 2. Bhupal Nobles' College of Pharmacy, Udaipur 313001, India
- 3. Himachal Institute of Pharmacy, Paonta Sahib, Himachal Pradesh, India
Description
A series of of Chalconyl Incorporated Schiff’s Bases of Sulphonamides was synthesized by reacting substituted chalcone
derivatives with Sulphacetamide sodium in methanol. All the title compounds synthesized (2a-2d) were tested for
antibacterial and antifungal activity using E. coli, P. aeruginosa, S. aureus, S. pyogenus and C. albicans, A. niger and A.
clavatus respectively as microbial strains and Sulphacetamide sodium as standard. The compound 2d showed significant
antibacterial activity and 2a showed moderate antifungal activity as compared with Sulphacetamide Sodium.
Abstract (English)
A series of of Chalconyl Incorporated Schiff’s Bases of Sulphonamides was synthesized by reacting substituted chalcone
derivatives with Sulphacetamide sodium in methanol. All the title compounds synthesized (2a-2d) were tested for
antibacterial and antifungal activity using E. coli, P. aeruginosa, S. aureus, S. pyogenus and C. albicans, A. niger and A.
clavatus respectively as microbial strains and Sulphacetamide sodium as standard. The compound 2d showed significant
antibacterial activity and 2a showed moderate antifungal activity as compared with Sulphacetamide Sodium.
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IJCPR,Vol8,Issue3,Article10.pdf
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Additional details
Dates
- Accepted
-
2017-06-17