SYNTHESIS AND ASSESSMENT THE IN-VITRO ANTIOXIDANT ACTIVITY OF 2,3-DISUBTITUTED QUINAZOLIN-4(3H)-ONE DERIVATIVES
Creators
- 1. Biyani Institute of Pharmaceutical Sciences, Jaipur, Rajasthan, India Arya College of Pharmacy, Jaipur,Rajasthan, India
Description
Quinazolinones have various biological activities such as anticancer, antibacterial,
antidiabetic, anticonvulsant, antihistaminic, antiinflammatory, antifungal, anthelmintics and
antiviral activities. In this research some of compounds 2,3-disubtituted quinazolin-4(3H)-
one derivatives had been synthesized under microwave irradiation. The compounds were
obtained from reaction some of benzoxazine derivatives with hydrazine hydrate using
microwave irradiation and the result of reaction we obtained 82-96%. The products had been
tested by IR, 1H-NMR, 13C-NMR and Mass Spectroscopy analysis. The using microwave
irradiation was more effective and efficient to produce compounds 2,3-disubtituted
quinazolin-4(3H)-one derivative because the reaction runs perfectly without any minor
products such as compounds N-(2-(hydrazinecarbonyl)phenyl)benzamide derivatives.
Abstract (English)
Quinazolinones have various biological activities such as anticancer, antibacterial,
antidiabetic, anticonvulsant, antihistaminic, antiinflammatory, antifungal, anthelmintics and
antiviral activities. In this research some of compounds 2,3-disubtituted quinazolin-4(3H)-
one derivatives had been synthesized under microwave irradiation. The compounds were
obtained from reaction some of benzoxazine derivatives with hydrazine hydrate using
microwave irradiation and the result of reaction we obtained 82-96%. The products had been
tested by IR, 1H-NMR, 13C-NMR and Mass Spectroscopy analysis. The using microwave
irradiation was more effective and efficient to produce compounds 2,3-disubtituted
quinazolin-4(3H)-one derivative because the reaction runs perfectly without any minor
products such as compounds N-(2-(hydrazinecarbonyl)phenyl)benzamide derivatives.
Files
IJCPR,Vol12,Issue2,Article1.pdf
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Additional details
Dates
- Accepted
-
2020-05-05