FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS

Description

Abstract (English)

The convenience of administration and improved patient compliance are essential in the
design of oral drug delivery system which remains the preferred route of drug delivery
instead of various limitations. Fast disintegrating tablets (FDTs) have gained ever-increasing
demand during the last decade, and the field has become a rapidly growing area in the
pharmaceutical industry. The popularity and usefulness of the formulation resulted in
development of several FDT technologies. These techniques give the disintegration of tablet
rapidly and dissolve in mouth within one-minute seconds without chewing and the need of
water, which is advantageous mainly for pediatrics, geriatrics and patients having problem in
swallowing tablets and capsules. Formulation of a suitable dosage form for administration, by
bearing swallowing difficulty and poor patient compliance, leads to development of orally
disintegrating tablets. The conventional preparation methods are spray drying, freeze drying,
direct compression, molding and sublimation while new technologies have been developed
for the production of orodispersible tablets.