Thyroid Dysfunction in Pregnancy: Impact on Maternal and Foetal Outcome
- 1. 1Assistant professor, Department of Gynecology and obstetrics, Kakatiya medical College: Nizampura, Rangampet Street, Warangal, Telangana, India-506007
- 2. 2Assistant professor, Department of Gynecology and obstetrics, Kakatiya medical College: Nizampura, Rangampet Street, Warangal, Telangana, India-506007
- 3. Consultant and Center head, Department of Gynecology and obstetrics, Indira IVF Center, Warangal, Telangana, India-506007
Description
Aims To know the prevalence of Thyroid Disorders in antenatal women and abnormal Thyroid function on the
maternal and foetal Outcome.
Materials and methods: The present study was conducted in Prathima institute of medical sciences,
Karimnagar from November 2014 to October 2016. It is a prospective study included screening of 1000
pregnant women coming to routine antenatal check-up in first trimester. TSH level was estimated, If it is
deranged, then FT3 & FT4 levels estimated. Patients were managed accordingly and followed till delivery.
Their obstetric and perinatal outcomes were noted.
Results: The prevalence of thyroid disorders in our study was 13% with a CI of 11.05- 15.23%.The prevalence
of subclinical hypothyroidism in our study was 7.1%. The prevalence of overt hypothyroidism in our study was
3.6%. The prevalence of subclinical and overt hyperthyroidism in our study was 1.9% & 0.4% respectively. In
our study, subclinical hypothyroidism was associated with complications like Pre-eclampsia (14.1%), Abruptio
placenta (4.2%), Preterm delivery (11.2%), Abortions (4.2%), Anaemia (35.2%), OLIGO (14.1%) IUGR (7%),
Low birth weight (5.6%), still born (1.4%). Overt hypothyroidism was associated with complications like Preeclampsia (19.4%), Abruptio placenta (2.8%), Preterm delivery (13.9%), Abortions (11.1%), Anaemia (33.3%),
OLIGO (16.7%), IUGR (11.1%), Low birth weight (11.1%), Still born (2.8%). Subclinical hyperthyroidism was
associated with complications like Pre-eclampsia (10.5%), Preterm delivery (10.5%), Abortions (5.2%),
Anaemia (31.6), OLIGO (21.05%), IUGR (10.5%), and Low birth weight (5.2%). Overt hyperthyroidism was
associated with complications like Abortions (50%), Pre-eclampsia (25%), Anaemia (25%), Preterm delivery
(25%), OLIGO (25%), IUGR (25%). The incidence of Anaemia was significantly high in subclinical hypo, overt
hypo, and subclinical hyper and overt hyper groups. Prevalence of thyroid dysfunction was high in this study,
with subclinical hypothyroidism in (7.1%) and overt hypothyroidism in (3.6%) women. Overt hyperthyroid
were prone to have miscarriage (50%) which was significantly high.
Conclusion: All women with thyroid disorders should be counselled about the importance of achieving
euthyroidism before conception to avoid poor outcomes. In patients with ↑TSH and normal FT3, FT4 antibody
testing for thyroid peroxidise (TPO) should be offered routinely. Early universal screening in first trimester will
optimise fetal outcome.
Abstract (English)
Aims To know the prevalence of Thyroid Disorders in antenatal women and abnormal Thyroid function on the
maternal and foetal Outcome.
Materials and methods: The present study was conducted in Prathima institute of medical sciences,
Karimnagar from November 2014 to October 2016. It is a prospective study included screening of 1000
pregnant women coming to routine antenatal check-up in first trimester. TSH level was estimated, If it is
deranged, then FT3 & FT4 levels estimated. Patients were managed accordingly and followed till delivery.
Their obstetric and perinatal outcomes were noted.
Results: The prevalence of thyroid disorders in our study was 13% with a CI of 11.05- 15.23%.The prevalence
of subclinical hypothyroidism in our study was 7.1%. The prevalence of overt hypothyroidism in our study was
3.6%. The prevalence of subclinical and overt hyperthyroidism in our study was 1.9% & 0.4% respectively. In
our study, subclinical hypothyroidism was associated with complications like Pre-eclampsia (14.1%), Abruptio
placenta (4.2%), Preterm delivery (11.2%), Abortions (4.2%), Anaemia (35.2%), OLIGO (14.1%) IUGR (7%),
Low birth weight (5.6%), still born (1.4%). Overt hypothyroidism was associated with complications like Preeclampsia (19.4%), Abruptio placenta (2.8%), Preterm delivery (13.9%), Abortions (11.1%), Anaemia (33.3%),
OLIGO (16.7%), IUGR (11.1%), Low birth weight (11.1%), Still born (2.8%). Subclinical hyperthyroidism was
associated with complications like Pre-eclampsia (10.5%), Preterm delivery (10.5%), Abortions (5.2%),
Anaemia (31.6), OLIGO (21.05%), IUGR (10.5%), and Low birth weight (5.2%). Overt hyperthyroidism was
associated with complications like Abortions (50%), Pre-eclampsia (25%), Anaemia (25%), Preterm delivery
(25%), OLIGO (25%), IUGR (25%). The incidence of Anaemia was significantly high in subclinical hypo, overt
hypo, and subclinical hyper and overt hyper groups. Prevalence of thyroid dysfunction was high in this study,
with subclinical hypothyroidism in (7.1%) and overt hypothyroidism in (3.6%) women. Overt hyperthyroid
were prone to have miscarriage (50%) which was significantly high.
Conclusion: All women with thyroid disorders should be counselled about the importance of achieving
euthyroidism before conception to avoid poor outcomes. In patients with ↑TSH and normal FT3, FT4 antibody
testing for thyroid peroxidise (TPO) should be offered routinely. Early universal screening in first trimester will
optimise fetal outcome.
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Additional details
Dates
- Accepted
-
2023-08-27