Comparison of Intravenous Midazolam and Dexmedetomidine Effects
Authors/Creators
- 1. Special Medical Officer, Rural Hospital, Abhona Nashik, Maharashtra, India
- 2. Associate Professor, Department of Anaesthesia, Topiwala National Medical College and Nair Hospital, Mumbai, Maharashtra, India
- 3. Senior Resident, Department of Anaesthesia, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
- 4. Assistant Professor, Department of Anaesthesia- Trauma, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
- 5. Professor and Head, Department of Anaesthesia, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
Description
Introduction: Spinal anesthesia is a very commonly used procedure in modern day anesthesia practice. Today most of the lower limb and infraumblical surgeries are performed under spinal anaesthesia. Midazolam and dexmedetomidine are common intravenous adjuvants used during anaesthesia to alley anxiety and sedation. The aim of this study was to compare the effects if intravenous midazolam and dexmedetomidine in terms of analgesic characteristics, sedation and adverse effects. Material and Methods: This is a randomised prospective study which included 30 patients in two groups, posted for lower limb orthopaedic surgery. Intravenous midazolam and dexmedetomidine was administered after subarachnoid block. Data for block characteristics, sedation, hemodynamic parameter and adverse effects were recorded. Results: Both the groups were comparable in terms of age, weight and ASA grade. The mean age for dexmedetomidine was 38.83 +13.69 years and for Midazolam group was 35.76 + 13.54 and 110 +8.61 minutes for midazolam group. The two dermatomal sensory regression was 137.6 + 10.40 minutes and 110 + 8.61 minutes for midazolam group. This difference was statistically significant with p value <0.001, with 95% CL [22.73-32.60]. Conclusion: In conclusion intravenous dexmedetomidine significantly prolongs the duration of sensory and motor block of bupivacaine in spinal anesthesia compared to midazolam. Intravenous dexmedetomidine supplementation during SAB provides intraoperative sedation equivalent to midazolam without causing respiratory depression. However, there were incidences of bradycardia and hypotension in dexmedetomine group.
Abstract (English)
Introduction: Spinal anesthesia is a very commonly used procedure in modern day anesthesia practice. Today most of the lower limb and infraumblical surgeries are performed under spinal anaesthesia. Midazolam and dexmedetomidine are common intravenous adjuvants used during anaesthesia to alley anxiety and sedation. The aim of this study was to compare the effects if intravenous midazolam and dexmedetomidine in terms of analgesic characteristics, sedation and adverse effects. Material and Methods: This is a randomised prospective study which included 30 patients in two groups, posted for lower limb orthopaedic surgery. Intravenous midazolam and dexmedetomidine was administered after subarachnoid block. Data for block characteristics, sedation, hemodynamic parameter and adverse effects were recorded. Results: Both the groups were comparable in terms of age, weight and ASA grade. The mean age for dexmedetomidine was 38.83 +13.69 years and for Midazolam group was 35.76 + 13.54 and 110 +8.61 minutes for midazolam group. The two dermatomal sensory regression was 137.6 + 10.40 minutes and 110 + 8.61 minutes for midazolam group. This difference was statistically significant with p value <0.001, with 95% CL [22.73-32.60]. Conclusion: In conclusion intravenous dexmedetomidine significantly prolongs the duration of sensory and motor block of bupivacaine in spinal anesthesia compared to midazolam. Intravenous dexmedetomidine supplementation during SAB provides intraoperative sedation equivalent to midazolam without causing respiratory depression. However, there were incidences of bradycardia and hypotension in dexmedetomine group.
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IJPCR,Vol15,Issue5,Article284.pdf
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Additional details
Dates
- Accepted
-
2023-05-05
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue5,Article284.pdf
- Development Status
- Active
References
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